JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

྾

Home
Applications
Clinical Diagnosis
Metabolism
Acetyl-Pepstatin - 95%, high purity , CAS No.28575-34-0

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Acetyl-Pepstatin - 95%, high purity , CAS No.28575-34-0

3 Citations

≥95%

CAS#: 28575-34-0
Formula: C₃₁H₅₇N₅O₉
Molecular Weight: 643.82
PubChem CID: 5481345

Item Number

A338138

Grouped product items
SKU	Size	Availability	Price
A338138-1mg	1mg	In stock	$165.90
A338138-5mg	5mg	In stock	$743.90
A338138-25mg	25mg	In stock	$3,347.90
A338138-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$12,050.90

an inhibitor of aspartyl protease and HIV proteinase

Basic Description

Synonyms	S-PI (pepsin inhibitor) \| J-017129 \| SCHEMBL10777706 \| DTXSID70182781 \| Pepsin inhibitor (Streptomyces naniwaensis) \| Pepsin inhibitor S-PI-D (8CI) \| L-valinamide, N-acetyl-L-valyl-N-[(1S,2S)-4-[[(1S)-2-[[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbut
Specifications & Purity	≥95%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Acetyl-Pepstatin is an aspartyl protease inhibitor. It has been found to effectively inhibit HIV-1 protease and HIV-2 protease. It was also found to suppress 125I-H77, a renin inhibitor, from binding to other aspartyl proteases.

Product Properties

pKa	pKₐ: 4.17
Ki Data	HIV-1 proteinase: Ki= 20 nM at pH 4.7; HIV-2 proteinase: Ki= 5 nM at pH 4.7

Associated Targets(Human)

CTSB Tchem Cathepsin B (3822 Activities)

Discover Target: CTSB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MCF7 (126967 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MDA-MB-231 (73002 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 protease (9113 Activities)

Discover Target: pol

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

protease Human rhinovirus A protease (1343 Activities)

Discover Target: protease

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid
INCHI	InChI=1S/C31H57N5O9/c1-15(2)11-21(35-30(44)28(18(7)8)36-31(45)27(17(5)6)33-20(10)37)23(38)13-25(40)32-19(9)29(43)34-22(12-16(3)4)24(39)14-26(41)42/h15-19,21-24,27-28,38-39H,11-14H2,1-10H3,(H,32,40)(H,33,37)(H,34,43)(H,35,44)(H,36,45)(H,41,42)/t19-,21-,22-,23-,24-,27-,28-/m0/s1
InChi Key	WKYBEGDEGRCZNF-LBTYKNIQSA-N
Canonical SMILES	CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC(=O)C)O
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)C)O
WGK Germany	3
PubChem CID	5481345
Molecular Weight	643.82

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
A2213097	Certificate of Analysis	Oct 22, 2024	A338138
A2213098	Certificate of Analysis	Oct 22, 2024	A338138
A2213099	Certificate of Analysis	Oct 22, 2024	A338138
A2213100	Certificate of Analysis	Oct 22, 2024	A338138

Chemical and Physical Properties

Solubility	Soluble in 50% acetic acid.
Sensitivity	Heat sensitive
Refractive Index	n20D1.51 (Predicted)
Boil Point(°C)	992.79° C at 760 mmHg (Predicted)

Safety and Hazards(GHS)

WGK Germany	3

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Dan Zhao, Mengyu Xu, Kang Dai, Huan Liu, Yan Jiao, Xincai Xiao. (2023) The preparation of chiral carbon dots and the study on their antibacterial abilities. MATERIALS CHEMISTRY AND PHYSICS, 295 (127144). [PMID:] [10.1016/j.matchemphys.2022.127144]
2. Ning Wang, Xinxin Han, Junya Li, Ying Wang, Wenquan Yu, Ruiyong Wang, Junbiao Chang. (2019) Comparative study of the bindings between 3-phenyl-1H-indazole and five proteins by isothermal titration calorimetry, spectroscopy and docking methods. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, [PMID:30488774] [10.1080/07391102.2018.1554511]
3. Jia Xu, Yuanyuan Zhai, Li Feng, Tong Xie, Weifeng Yao, Jinjun Shan, Li Zhang. (2019) An optimized analytical method for cellular targeted quantification of primary metabolites in tricarboxylic acid cycle and glycolysis using gas chromatography-tandem mass spectrometry and its application in three kinds of hepatic cell lines. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 171 (171). [PMID:31005043] [10.1016/j.jpba.2019.04.022]

References

1. Dan Zhao, Mengyu Xu, Kang Dai, Huan Liu, Yan Jiao, Xincai Xiao. (2023) The preparation of chiral carbon dots and the study on their antibacterial abilities. MATERIALS CHEMISTRY AND PHYSICS, 295 (127144). [PMID:] [10.1016/j.matchemphys.2022.127144]
2. Ning Wang, Xinxin Han, Junya Li, Ying Wang, Wenquan Yu, Ruiyong Wang, Junbiao Chang. (2019) Comparative study of the bindings between 3-phenyl-1H-indazole and five proteins by isothermal titration calorimetry, spectroscopy and docking methods. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, [PMID:30488774] [10.1080/07391102.2018.1554511]
3. Jia Xu, Yuanyuan Zhai, Li Feng, Tong Xie, Weifeng Yao, Jinjun Shan, Li Zhang. (2019) An optimized analytical method for cellular targeted quantification of primary metabolites in tricarboxylic acid cycle and glycolysis using gas chromatography-tandem mass spectrometry and its application in three kinds of hepatic cell lines. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 171 (171). [PMID:31005043] [10.1016/j.jpba.2019.04.022]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.