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Acetyl Podocarpic Acid Anhydride , CAS No.344327-48-6, Agonist of Liver X receptor-α;Agonist of Liver X receptor-β

Moligand™

CAS#: 344327-48-6
Formula: C₃₈H₄₆O₇
Molecular Weight: 614.75
PubChem CID: 9830426

Item Number

A346580

Grouped product items
SKU	Size	Availability	Price	Qty
A346580-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$78.90
A346580-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$325.90

a potent, semi-synthetic LXR (liver X receptor) agonist

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Liver X receptor-α Agonist Liver X receptor-β Agonist

Basic Description

Specifications & Purity	Moligand™
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of Liver X receptor-α;Agonist of Liver X receptor-β
Product Description	Acetyl podocarpic acid anhydride (APD) is a potent, semi-synthetic liver X receptor (LXR) agonist derived from extracts of the mayapple. APD forms a heterodimer with the retinoid X receptor (RXR), and together these compounds, acting through LXR, induce the expression of the ABCA1 reverse cholesterol transporter and inhibit the overall absorption of cholesterol (ED\|50\|= 1 nM). In transient transactivation assays, acetyl podocarpic acid anhydride was found to be approximately 1,000 times more potent than 22(R)-hydroxy cholesterol. APD can be used as a positive control for the testing of LXR agonists.

Associated Targets

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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NR1H2 Tchem Oxysterols receptor LXR-beta 1 Activities

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NR1H3 Tchem Oxysterols receptor LXR-alpha 2 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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Names and Identifiers

IUPAC Name	[(1S,4aS,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carbonyl] (1S,4aS,10aR)-6-acetyloxy-1,4a-dimethyl-2,3,4,9,10,10a-hexahydrophenanthrene-1-carboxylate
INCHI	InChI=1S/C38H46O7/c1-23(39)43-27-13-9-25-11-15-31-35(3,29(25)21-27)17-7-19-37(31,5)33(41)45-34(42)38(6)20-8-18-36(4)30-22-28(44-24(2)40)14-10-26(30)12-16-32(36)38/h9-10,13-14,21-22,31-32H,7-8,11-12,15-20H2,1-6H3/t31-,32-,35-,36-,37+,38+/m1/s1
InChi Key	OUJQRQRBNRGQTC-SPGSYPTKSA-N
Canonical SMILES	CC(=O)OC1=CC2=C(CCC3C2(CCCC3(C)C(=O)OC(=O)C4(CCCC5(C4CCC6=C5C=C(C=C6)OC(=O)C)C)C)C)C=C1
Isomeric SMILES	CC(=O)OC1=CC2=C(CC[C@@H]3[C@@]2(CCC[C@]3(C)C(=O)OC(=O)[C@]4(CCC[C@]5([C@H]4CCC6=C5C=C(C=C6)OC(=O)C)C)C)C)C=C1
PubChem CID	9830426
Molecular Weight	614.75

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

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