Grouped product items

SKU

Size

Availability

Price

Qty

A111015-25g

25g

Available within 4-8 weeks(?)

$266.90

A111015-100g

100g

Available within 4-8 weeks(?)

$899.90

Basic Description

Synonyms	ACETYLCHOLINE CHLORIDE \| 60-31-1 \| Miochol \| Acecoline \| Acecholin \| ACH chloride \| Chloroacetylcholine \| Arterocoline \| Ovisot \| Azetylcholinchlorid \| 2-(Acetyloxy)-N,N,N-trimethylethanaminium chloride \| MIOCHOL-E \| Acetylcholinium chloride \| O-Acetylcholine chloride \| 2-Acetoxyeth
Specifications & Purity	for cell culture, ≥99%
Biochemical and Physiological Mechanisms	Endogenous neurotransmitter in both the central and peripheral nervous systems. Displays activity at the nicotinic and muscarinic acetylcholine receptors. Also implicated in numerous non-neuronal roles.
Storage Temp	Store at 2-8°C,Protected from light,Argon charged,Desiccated
Shipped In	Wet ice
Grade	for cell culture
Action Type	AGONIST
Mechanism of action	Muscarinic acetylcholine receptor M3 agonist
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CBX1 Tbio Chromobox protein homolog 1 (0 Activities)

Discover Target: CBX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPC4 Tchem Short transient receptor potential channel 4 (0 Activities)

Discover Target: TRPC4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNNC1 Tclin Troponin C, slow skeletal and cardiac muscles (0 Activities)

Discover Target: TNNC1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLC5A7 Tchem High affinity choline transporter 1 (0 Activities)

Discover Target: SLC5A7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM5 Tclin Muscarinic acetylcholine receptor M5 (0 Activities)

Discover Target: CHRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (0 Activities)

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)

Discover Target: APEX1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (0 Activities)

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TARDBP Tchem TAR DNA-binding protein 43 (0 Activities)

Discover Target: TARDBP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor (0 Activities)

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)

Discover Target: CHRM5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)

Discover Target: CHRM3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC5A7 Tchem High-affinity choline transporter (1462 Activities)

Discover Target: SLC5A7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TNNC1 Tclin Troponin, cardiac muscle (276 Activities)

Discover Target: TNNC1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pseudomonas aeruginosa (123386 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Klebsiella pneumoniae (43867 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Acinetobacter baumannii (41033 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptococcus neoformans (21258 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Candida albicans (78123 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpc4 Short transient receptor potential channel 4 (1615 Activities)

Discover Target: Trpc4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

vpr Aberrant vpr protein (14595 Activities)

Discover Target: vpr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-acetyloxyethyl(trimethyl)azanium;chloride
INCHI	InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChi Key	JUGOREOARAHOCO-UHFFFAOYSA-M
Canonical SMILES	CC(=O)OCC[N+](C)(C)C.[Cl-]
Isomeric SMILES	CC(=O)OCC[N+](C)(C)C.[Cl-]
WGK Germany	2
RTECS	FZ9800000
PubChem CID	6060
Molecular Weight	181.66
Beilstein	3571875
Reaxy-Rn	3571875

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot Number	Certificate Type	Date	Item
I2312039	Certificate of Analysis	Sep 04, 2023	A111015
I2312040	Certificate of Analysis	Sep 04, 2023	A111015
E2225144	Certificate of Analysis	Mar 22, 2022	A111015
E2225151	Certificate of Analysis	Mar 22, 2022	A111015
H2328116	Certificate of Analysis	Mar 22, 2022	A111015

Chemical and Physical Properties

Solubility	water: 100 mg/mL, clear, colorless
Sensitivity	Light and moisture sensitive
Melt Point(°C)	149-152°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	FZ9800000
Reaxy-Rn	3571875
Merck Index	87

FAQs and Articles

FAQ

The Key Molecule in Neurotransmission—Acetylcholine

Categories: Technical articles

Tags:

Metabolites Acetylcholine Nucleosides and nucleotides Coenzymes In vitro diagnostics Metabolism Neuroscience Nerve signaling

Citations of This Product

1. Li Qiwei, Chen Zaozao, Zhang Ying, Ding Shuang, Ding Haibo, Wang Luping, Xie Zhuoying, Fu Yifu, Wei Mengxiao, Liu Shengnan, Chen Jialun, Wang Xuan, Gu Zhongze. (2023) Imaging cellular forces with photonic crystals. Nature Communications, 14 (1): (1-14). [PMID:37963911]
2. Guorui Chang, Sirui Li, Yunqi Wang, Qingxia Ran, Qing Tan, Shuli Gou, Haiying Du, Shuxia Xu. (2024) Cu-C3N4 nanoenzyme-based freezing-dried bioactive capsule integrated with 3D-printed smartphone platform for visual detection of organophosphorus pesticides paraoxon in scallion. SENSORS AND ACTUATORS B-CHEMICAL, 398 (1): (134584). [PMID:17505538]
3. Zhe Ling, Yang Tan, Xinjian Li, Ying Xie, Peng Wang, Yan Su, Qiang Yong. (2023) Elucidating multi-scale deconstruction of bamboo crystalline cellulose by novel acetylcholine chloride based deep eutectic solvents for enhanced enzymatic hydrolysis. INDUSTRIAL CROPS AND PRODUCTS, 203 (117156). [PMID:]
4. Yaxu Zhao, Lijun Liang, Wei Guo, Xiong Lu, Congyi Zhao, Faming Gao. (2023) The porous hollow cobalt-based oxides encapsulated with bimetallic PdAu Nanoparticles of electrochemical biosensor for highly sensitive pesticides detection. NANOTECHNOLOGY, 34 (28): (285501). [PMID:37054697]
5. Zhou Liping, Lao Zishan, Fan Xinsheng, Hao Mengyang, Yang Yubing. (2023) Sulfur dioxide derivatives aggravated ovalbumin-induced asthma through targeting TRPV1 and tight junctions. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, [PMID:37073125]
6. Wang Kai, Liang Yaping, Duan Manman, Che Wunan, He Lu. (2023) Chronic toxicity of broflanilide in Daphnia magna: changes in molting, behavior, and gene expression. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (19): (54846-54856). [PMID:36881221]
7. Haoge Cheng, Kaiyue Yang, Yuze Zhang, Shenglong Liao, Menghao Du, Jiaqi Li, Ning Ma, Mianqi Xue, Xinyue Zhang, Yapei Wang. (2022) A Novel Ionic Conductive Polyurethane Based on Deep Eutectic Solvent Continuing Traditional Merits. ACS Applied Materials & Interfaces, 14 (46): (52402–52410). [PMID:36256442]
8. Hangjing Zhang, Tianyuan Gao, Lei Jiang, Xiangqi Meng, Jian Wang, Ning Ma, Hao Wei, Xinyue Zhang. (2022) Conductive and transparent poly (N-isopropylacrylamide) hydrogels with tunable LCST copolymerized by the green acrylamide-based deep eutectic solvent. EUROPEAN POLYMER JOURNAL, 173 (111266). [PMID:]
9. Zhiang Zhang, Jikun Jiang, Xiao (Xiao) Liu, Xin Wang, Luyao Wang, Yuankun Qiu, Zhanfei Zhang, Yiting Zheng, Xueyun Wu, Jianghu Liang, Congcong Tian, Chun-Chao Chen. (2021) Surface-Anchored Acetylcholine Regulates Band-Edge States and Suppresses Ion Migration in a 21%-Efficient Quadruple-Cation Perovskite Solar Cell. Small, 18 (6): (2105184). [PMID:34851037]

References

1. Radzicki D et al.. (2017) Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.. J Neurosci, 37 (9): (2292-2304). [PMID:28137966]
2. Li Qiwei, Chen Zaozao, Zhang Ying, Ding Shuang, Ding Haibo, Wang Luping, Xie Zhuoying, Fu Yifu, Wei Mengxiao, Liu Shengnan, Chen Jialun, Wang Xuan, Gu Zhongze. (2023) Imaging cellular forces with photonic crystals. Nature Communications, 14 (1): (1-14). [PMID:37963911]
3. Guorui Chang, Sirui Li, Yunqi Wang, Qingxia Ran, Qing Tan, Shuli Gou, Haiying Du, Shuxia Xu. (2024) Cu-C3N4 nanoenzyme-based freezing-dried bioactive capsule integrated with 3D-printed smartphone platform for visual detection of organophosphorus pesticides paraoxon in scallion. SENSORS AND ACTUATORS B-CHEMICAL, 398 (1): (134584). [PMID:17505538]
4. Zhe Ling, Yang Tan, Xinjian Li, Ying Xie, Peng Wang, Yan Su, Qiang Yong. (2023) Elucidating multi-scale deconstruction of bamboo crystalline cellulose by novel acetylcholine chloride based deep eutectic solvents for enhanced enzymatic hydrolysis. INDUSTRIAL CROPS AND PRODUCTS, 203 (117156). [PMID:]
5. Yaxu Zhao, Lijun Liang, Wei Guo, Xiong Lu, Congyi Zhao, Faming Gao. (2023) The porous hollow cobalt-based oxides encapsulated with bimetallic PdAu Nanoparticles of electrochemical biosensor for highly sensitive pesticides detection. NANOTECHNOLOGY, 34 (28): (285501). [PMID:37054697]
6. Zhou Liping, Lao Zishan, Fan Xinsheng, Hao Mengyang, Yang Yubing. (2023) Sulfur dioxide derivatives aggravated ovalbumin-induced asthma through targeting TRPV1 and tight junctions. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, [PMID:37073125]
7. Wang Kai, Liang Yaping, Duan Manman, Che Wunan, He Lu. (2023) Chronic toxicity of broflanilide in Daphnia magna: changes in molting, behavior, and gene expression. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (19): (54846-54856). [PMID:36881221]
8. Haoge Cheng, Kaiyue Yang, Yuze Zhang, Shenglong Liao, Menghao Du, Jiaqi Li, Ning Ma, Mianqi Xue, Xinyue Zhang, Yapei Wang. (2022) A Novel Ionic Conductive Polyurethane Based on Deep Eutectic Solvent Continuing Traditional Merits. ACS Applied Materials & Interfaces, 14 (46): (52402–52410). [PMID:36256442]
9. Hangjing Zhang, Tianyuan Gao, Lei Jiang, Xiangqi Meng, Jian Wang, Ning Ma, Hao Wei, Xinyue Zhang. (2022) Conductive and transparent poly (N-isopropylacrylamide) hydrogels with tunable LCST copolymerized by the green acrylamide-based deep eutectic solvent. EUROPEAN POLYMER JOURNAL, 173 (111266). [PMID:]
10. Zhiang Zhang, Jikun Jiang, Xiao (Xiao) Liu, Xin Wang, Luyao Wang, Yuankun Qiu, Zhanfei Zhang, Yiting Zheng, Xueyun Wu, Jianghu Liang, Congcong Tian, Chun-Chao Chen. (2021) Surface-Anchored Acetylcholine Regulates Band-Edge States and Suppresses Ion Migration in a 21%-Efficient Quadruple-Cation Perovskite Solar Cell. Small, 18 (6): (2105184). [PMID:34851037]

Solution Calculators

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Acetylcholine chloride - for cell culture,≥99%, high purity , Muscarinic acetylcholine receptor M3 agonist, CAS No.60-31-1, Muscarinic acetylcholine receptor M3 agonist