Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A111015-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $266.90 | |
A111015-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $899.90 |
Endogenous neurotransmitter active at acetylcholine receptors
Synonyms | MLS000028640 | NCGC00018123-07 | SCHEMBL40885 | Acetylcholine chloride (USP:INN:BAN:JAN) | Acetylcholine hydrochloride | AI3-51676 | REGID_for_CID_6060 | 2-acetyloxy-N,N,N-trimethylethanaminium chloride | AKOS005111031 | O-Acetylcholine chloride | 2-acety |
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Specifications & Purity | for cell culture, ≥99% |
Biochemical and Physiological Mechanisms | Endogenous neurotransmitter in both the central and peripheral nervous systems. Displays activity at the nicotinic and muscarinic acetylcholine receptors. Also implicated in numerous non-neuronal roles. |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged,Desiccated |
Shipped In | Wet ice |
Grade | for cell culture |
Action Type | AGONIST |
Mechanism of action | Muscarinic acetylcholine receptor M3 agonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | 2-acetyloxyethyl(trimethyl)azanium;chloride |
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INCHI | InChI=1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1 |
InChi Key | JUGOREOARAHOCO-UHFFFAOYSA-M |
Canonical SMILES | CC(=O)OCC[N+](C)(C)C.[Cl-] |
Isomeric SMILES | CC(=O)OCC[N+](C)(C)C.[Cl-] |
WGK Germany | 2 |
RTECS | FZ9800000 |
PubChem CID | 6060 |
Molecular Weight | 181.66 |
Beilstein | 3571875 |
Reaxy-Rn | 3571875 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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I2312039 | Certificate of Analysis | Sep 04, 2023 | A111015 |
I2312040 | Certificate of Analysis | Sep 04, 2023 | A111015 |
E2225144 | Certificate of Analysis | Mar 22, 2022 | A111015 |
E2225151 | Certificate of Analysis | Mar 22, 2022 | A111015 |
H2328116 | Certificate of Analysis | Mar 22, 2022 | A111015 |
Solubility | water: 100 mg/mL, clear, colorless |
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Sensitivity | Light and moisture sensitive |
Melt Point(°C) | 149-152°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 2 |
RTECS | FZ9800000 |
Reaxy-Rn | 3571875 |
Merck Index | 87 |
1. Li Qiwei, Chen Zaozao, Zhang Ying, Ding Shuang, Ding Haibo, Wang Luping, Xie Zhuoying, Fu Yifu, Wei Mengxiao, Liu Shengnan, Chen Jialun, Wang Xuan, Gu Zhongze. (2023) Imaging cellular forces with photonic crystals. Nature Communications, 14 (1): (1-14). [PMID:37963911] [10.1038/s41467-023-43090-9] |
2. Guorui Chang, Sirui Li, Yunqi Wang, Qingxia Ran, Qing Tan, Shuli Gou, Haiying Du, Shuxia Xu. (2024) Cu-C3N4 nanoenzyme-based freezing-dried bioactive capsule integrated with 3D-printed smartphone platform for visual detection of organophosphorus pesticides paraoxon in scallion. SENSORS AND ACTUATORS B-CHEMICAL, 398 (1): (134584). [PMID:17505538] [10.1016/j.snb.2023.134584] |
3. Zhe Ling, Yang Tan, Xinjian Li, Ying Xie, Peng Wang, Yan Su, Qiang Yong. (2023) Elucidating multi-scale deconstruction of bamboo crystalline cellulose by novel acetylcholine chloride based deep eutectic solvents for enhanced enzymatic hydrolysis. INDUSTRIAL CROPS AND PRODUCTS, 203 (117156). [PMID:] [10.1016/j.indcrop.2023.117156] |
4. Yaxu Zhao, Lijun Liang, Wei Guo, Xiong Lu, Congyi Zhao, Faming Gao. (2023) The porous hollow cobalt-based oxides encapsulated with bimetallic PdAu Nanoparticles of electrochemical biosensor for highly sensitive pesticides detection. NANOTECHNOLOGY, 34 (28): (285501). [PMID:37054697] [10.1088/1361-6528/accc8f] |
5. Zhou Liping, Lao Zishan, Fan Xinsheng, Hao Mengyang, Yang Yubing. (2023) Sulfur dioxide derivatives aggravated ovalbumin-induced asthma through targeting TRPV1 and tight junctions. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, [PMID:37073125] [10.1093/bbb/zbad039] |
6. Wang Kai, Liang Yaping, Duan Manman, Che Wunan, He Lu. (2023) Chronic toxicity of broflanilide in Daphnia magna: changes in molting, behavior, and gene expression. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (19): (54846-54856). [PMID:36881221] [10.1007/s11356-023-26255-3] |
7. Haoge Cheng, Kaiyue Yang, Yuze Zhang, Shenglong Liao, Menghao Du, Jiaqi Li, Ning Ma, Mianqi Xue, Xinyue Zhang, Yapei Wang. (2022) A Novel Ionic Conductive Polyurethane Based on Deep Eutectic Solvent Continuing Traditional Merits. ACS Applied Materials & Interfaces, 14 (46): (52402–52410). [PMID:36256442] [10.1021/acsami.2c15356] |
8. Hangjing Zhang, Tianyuan Gao, Lei Jiang, Xiangqi Meng, Jian Wang, Ning Ma, Hao Wei, Xinyue Zhang. (2022) Conductive and transparent poly (N-isopropylacrylamide) hydrogels with tunable LCST copolymerized by the green acrylamide-based deep eutectic solvent. EUROPEAN POLYMER JOURNAL, 173 (111266). [PMID:] [10.1016/j.eurpolymj.2022.111266] |
9. Zhiang Zhang, Jikun Jiang, Xiao (Xiao) Liu, Xin Wang, Luyao Wang, Yuankun Qiu, Zhanfei Zhang, Yiting Zheng, Xueyun Wu, Jianghu Liang, Congcong Tian, Chun-Chao Chen. (2021) Surface-Anchored Acetylcholine Regulates Band-Edge States and Suppresses Ion Migration in a 21%-Efficient Quadruple-Cation Perovskite Solar Cell. Small, 18 (6): (2105184). [PMID:34851037] [10.1002/smll.202105184] |
10. Xinyue Dai, Kai Le, Fenglong Wang, Rubin Wei, Jiurong Liu, Yanyan Jiang, Hui Li. (2020) Single-Molecule Detection of Acetylcholine by Translating the Neuronal Signal to a Single Distinct Electronic Peak. ACS Applied Bio Materials, 3 (10): (6888–6896). [PMID:35019350] [10.1021/acsabm.0c00797] |
11. Zhijiao Tang, Zhengyi Chen, Gongke Li, Yuling Hu. (2020) Multicolor nitrogen dots for rapid detection of thiram and chlorpyrifos in fruit and vegetable samples. ANALYTICA CHIMICA ACTA, 1136 (72). [PMID:33081951] [10.1016/j.aca.2020.08.038] |
12. Benhong Xu, Huixing Deng, Xiaojing Zhang, Jingxiong Luo, Gaoxiao Zhang, Zaijun Zhang, Yuqiang Wang, Luchen Shan. (2018) A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. EUROPEAN JOURNAL OF PHARMACOLOGY, 818 (158). [PMID:29066416] [10.1016/j.ejphar.2017.10.034] |
13. Lve Wang, Xu Chen, Changxia Liu, Wensheng Yang. (2016) Non-enzymatic acetylcholine electrochemical biosensor based on flower-like NiAl layered double hydroxides decorated with carbon dots. SENSORS AND ACTUATORS B-CHEMICAL, 233 (199). [PMID:] [10.1016/j.snb.2016.04.062] |
1. Radzicki D et al.. (2017) Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.. J Neurosci, 37 (9): (2292-2304). [PMID:28137966] |
2. Li Qiwei, Chen Zaozao, Zhang Ying, Ding Shuang, Ding Haibo, Wang Luping, Xie Zhuoying, Fu Yifu, Wei Mengxiao, Liu Shengnan, Chen Jialun, Wang Xuan, Gu Zhongze. (2023) Imaging cellular forces with photonic crystals. Nature Communications, 14 (1): (1-14). [PMID:37963911] [10.1038/s41467-023-43090-9] |
3. Guorui Chang, Sirui Li, Yunqi Wang, Qingxia Ran, Qing Tan, Shuli Gou, Haiying Du, Shuxia Xu. (2024) Cu-C3N4 nanoenzyme-based freezing-dried bioactive capsule integrated with 3D-printed smartphone platform for visual detection of organophosphorus pesticides paraoxon in scallion. SENSORS AND ACTUATORS B-CHEMICAL, 398 (1): (134584). [PMID:17505538] [10.1016/j.snb.2023.134584] |
4. Zhe Ling, Yang Tan, Xinjian Li, Ying Xie, Peng Wang, Yan Su, Qiang Yong. (2023) Elucidating multi-scale deconstruction of bamboo crystalline cellulose by novel acetylcholine chloride based deep eutectic solvents for enhanced enzymatic hydrolysis. INDUSTRIAL CROPS AND PRODUCTS, 203 (117156). [PMID:] [10.1016/j.indcrop.2023.117156] |
5. Yaxu Zhao, Lijun Liang, Wei Guo, Xiong Lu, Congyi Zhao, Faming Gao. (2023) The porous hollow cobalt-based oxides encapsulated with bimetallic PdAu Nanoparticles of electrochemical biosensor for highly sensitive pesticides detection. NANOTECHNOLOGY, 34 (28): (285501). [PMID:37054697] [10.1088/1361-6528/accc8f] |
6. Zhou Liping, Lao Zishan, Fan Xinsheng, Hao Mengyang, Yang Yubing. (2023) Sulfur dioxide derivatives aggravated ovalbumin-induced asthma through targeting TRPV1 and tight junctions. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, [PMID:37073125] [10.1093/bbb/zbad039] |
7. Wang Kai, Liang Yaping, Duan Manman, Che Wunan, He Lu. (2023) Chronic toxicity of broflanilide in Daphnia magna: changes in molting, behavior, and gene expression. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 30 (19): (54846-54856). [PMID:36881221] [10.1007/s11356-023-26255-3] |
8. Haoge Cheng, Kaiyue Yang, Yuze Zhang, Shenglong Liao, Menghao Du, Jiaqi Li, Ning Ma, Mianqi Xue, Xinyue Zhang, Yapei Wang. (2022) A Novel Ionic Conductive Polyurethane Based on Deep Eutectic Solvent Continuing Traditional Merits. ACS Applied Materials & Interfaces, 14 (46): (52402–52410). [PMID:36256442] [10.1021/acsami.2c15356] |
9. Hangjing Zhang, Tianyuan Gao, Lei Jiang, Xiangqi Meng, Jian Wang, Ning Ma, Hao Wei, Xinyue Zhang. (2022) Conductive and transparent poly (N-isopropylacrylamide) hydrogels with tunable LCST copolymerized by the green acrylamide-based deep eutectic solvent. EUROPEAN POLYMER JOURNAL, 173 (111266). [PMID:] [10.1016/j.eurpolymj.2022.111266] |
10. Zhiang Zhang, Jikun Jiang, Xiao (Xiao) Liu, Xin Wang, Luyao Wang, Yuankun Qiu, Zhanfei Zhang, Yiting Zheng, Xueyun Wu, Jianghu Liang, Congcong Tian, Chun-Chao Chen. (2021) Surface-Anchored Acetylcholine Regulates Band-Edge States and Suppresses Ion Migration in a 21%-Efficient Quadruple-Cation Perovskite Solar Cell. Small, 18 (6): (2105184). [PMID:34851037] [10.1002/smll.202105184] |
11. Xinyue Dai, Kai Le, Fenglong Wang, Rubin Wei, Jiurong Liu, Yanyan Jiang, Hui Li. (2020) Single-Molecule Detection of Acetylcholine by Translating the Neuronal Signal to a Single Distinct Electronic Peak. ACS Applied Bio Materials, 3 (10): (6888–6896). [PMID:35019350] [10.1021/acsabm.0c00797] |
12. Zhijiao Tang, Zhengyi Chen, Gongke Li, Yuling Hu. (2020) Multicolor nitrogen dots for rapid detection of thiram and chlorpyrifos in fruit and vegetable samples. ANALYTICA CHIMICA ACTA, 1136 (72). [PMID:33081951] [10.1016/j.aca.2020.08.038] |
13. Benhong Xu, Huixing Deng, Xiaojing Zhang, Jingxiong Luo, Gaoxiao Zhang, Zaijun Zhang, Yuqiang Wang, Luchen Shan. (2018) A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. EUROPEAN JOURNAL OF PHARMACOLOGY, 818 (158). [PMID:29066416] [10.1016/j.ejphar.2017.10.034] |
14. Lve Wang, Xu Chen, Changxia Liu, Wensheng Yang. (2016) Non-enzymatic acetylcholine electrochemical biosensor based on flower-like NiAl layered double hydroxides decorated with carbon dots. SENSORS AND ACTUATORS B-CHEMICAL, 233 (199). [PMID:] [10.1016/j.snb.2016.04.062] |