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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A104180-25g | 25g | In stock | $17.90 | |
A104180-100g | 100g | In stock | $30.90 | |
A104180-500g | 500g | In stock | $55.90 |
Cyclooxygenase inhibitor; NSAID
Synonyms | ASA | Acesal | Acetisal | Aspirdrops | Solpyron | A.S.A. empirin | Acetosal | Benaspir | Contrheuma retard | Acido acetilsalicilico | Bayer | Entericin | Kyselina 2-acetoxybenzoova | 8-hour Bayer | Acetylsalicylsaeure | Benzoic acid, 2-(acetyloxy)- | o-Ca |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Inhibitor of cyclooxygenase (COX)-1. Blocks the production of prostaglandins and thromboxanes. Exhibits antiplatelet and antithrombotic activities. Displays anticancer effects in some solid tumors. One of the first described NSAID drugs. |
Storage Temp | Desiccated |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Cyclooxygenase inhibitor |
Product Description | Aspirin is an antiinflammatory compound that inhibits NFκB, cylooxygenase-1 (Cox-1), and cyclooxygenase-2 (Cox-2). NFκB is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection. Adhesion molecules IL-1 and IL-6 are genes regulated by NFκB. Along with sodium salicylate, aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. Research indicates that aspirin acts at a site downstream of glutamate receptors and blocks induction of NFκB mediated by glutamate. Additional studies suggest that aspirin and sodium salicylate specifically inhibit IKKβ, which results in the blocking of NFκB genes responsible for the inflammatory response. Aspirin has also been described to elevate extracellular adenosine levels, downregulate the expression and activity of inducible NOS, decrease the levels of adenosine triphosphate, act on multiple mitogen-activated protein kinase activities, and block the uncoupling of oxidative phosphorylation. Studies reveal that aspirin alters the equilibrium of Mcl-1/Noxa, giving rise to apoptosis of leukemia cells, independent of NFκB and MAPKs. |
ALogP | 1.2 |
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Pubchem Sid | 488179680 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179680 |
IUPAC Name | 2-acetyloxybenzoic acid |
INCHI | InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) |
InChi Key | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)OC1=CC=CC=C1C(=O)O |
Isomeric SMILES | CC(=O)OC1=CC=CC=C1C(=O)O |
WGK Germany | 1 |
RTECS | VO0700000 |
PubChem CID | 2244 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 180.16 |
Beilstein | 779271 |
Reaxy-Rn | 779271 |
PubChem SID | 488179680 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2409170 | Certificate of Analysis | Jun 14, 2024 | A104180 |
G2409169 | Certificate of Analysis | Jun 14, 2024 | A104180 |
G2409168 | Certificate of Analysis | Jun 14, 2024 | A104180 |
G2409166 | Certificate of Analysis | Jun 14, 2024 | A104180 |
F2415101 | Certificate of Analysis | Mar 23, 2024 | A104180 |
F2426599 | Certificate of Analysis | Mar 23, 2024 | A104180 |
F2426598 | Certificate of Analysis | Mar 23, 2024 | A104180 |
F2206103 | Certificate of Analysis | Mar 18, 2022 | A104180 |
K2324099 | Certificate of Analysis | Mar 18, 2022 | A104180 |
F2306054 | Certificate of Analysis | Mar 18, 2022 | A104180 |
F2206105 | Certificate of Analysis | Mar 18, 2022 | A104180 |
F2206102 | Certificate of Analysis | Mar 18, 2022 | A104180 |
F2206008 | Certificate of Analysis | Mar 18, 2022 | A104180 |
F2206006 | Certificate of Analysis | Mar 18, 2022 | A104180 |
C2413094 | Certificate of Analysis | Mar 18, 2022 | A104180 |
A2225059 | Certificate of Analysis | Dec 20, 2021 | A104180 |
B2302420 | Certificate of Analysis | Dec 20, 2021 | A104180 |
B2302418 | Certificate of Analysis | Dec 20, 2021 | A104180 |
A2225062 | Certificate of Analysis | Dec 20, 2021 | A104180 |
A2225061 | Certificate of Analysis | Dec 20, 2021 | A104180 |
A2225060 | Certificate of Analysis | Dec 20, 2021 | A104180 |
Solubility | Solvent:water, Max Conc. mg/mL: 1.8, Max Conc. mM: 10; Solvent:DMSO, Max Conc. mg/mL: 18.02, Max Conc. mM: 100 |
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Sensitivity | Moisture sensitive. |
Flash Point(°F) | 446 °F |
Flash Point(°C) | 250℃ |
Melt Point(°C) | 136-140°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 1 |
RTECS | VO0700000 |
Reaxy-Rn | 779271 |
Class | 6.1 |
Merck Index | 851 |
Starting at $158.90
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30. Peilin Zhang, Shiru He, Siqi Wu, Yi Li, Huiying Wang, Changyang Yan, Hua Yang, Ping Li. (2022) Discovering a Multi-Component Combination against Vascular Dementia from Danshen-Honghua Herbal Pair by Spectrum-Effect Relationship Analysis. Pharmaceuticals, 15 (9): (1073). [PMID:36145294] |
31. Guanghui Ren, Yan Ma, Xingjie Wang, Zhaodi Zheng, Guorong Li. (2022) Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY, 932 (175208). [PMID:35981603] |
32. Shuwei Cai, Xian Li, Shijie Pu, Xinyu Ma, Xianru He. (2023) Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin. International Journal of Polymeric Materials and Polymeric Biomaterials, 72 (14): (1142-1150). [PMID:] |
33. Xianming Zhang, Qinghua Yu, Ping Zhou, Shiyu Yang, Jiashan Xia, Tao Deng, Chao Yu. (2022) Blood-brain barrier penetrating carbon dots with intrinsic anti-inflammatory and drug-loading properties. Biomaterials Advances, 139 (212995). [PMID:35882144] |
34. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie. (2022) Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food. Food Bioscience, 49 (101842). [PMID:] |
35. Yingfei Wang, Junhui Zhou, Fengliang Wang, Yi Xie, Shengwei Liu, Zhimin Ao, Chuanhao Li. (2022) Hydrogen generation from photocatalytic treatment of wastewater containing pharmaceuticals and personal care products by Oxygen-doped crystalline carbon nitride. SEPARATION AND PURIFICATION TECHNOLOGY, 296 (121425). [PMID:] |
36. Wang Yulin, Li Yangyang, Luo Yiling, Zhou Kailian, Qiu Xiuzhen, Guo Huishi. (2022) A novel molecularly imprinted polymer material for the recognition of ochratoxin A. JOURNAL OF POLYMER RESEARCH, 29 (5): (1-11). [PMID:] |
37. Wu Yusheng, Qin Dongmiao, Meng Shuo, Zhang Chuqing, Deng Biyang. (2022) Carbon quantum dots with blue/near infrared emissions for ratiometric fluorescent lornoxicam sensing and bio-imaging. MICROCHIMICA ACTA, 189 (4): (1-11). [PMID:35347472] |
38. Wu Yue, Li Kuangyu, Zeng Maolin, Qiao Boyang, Zhou Benhong. (2022) Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute Inflammation. Frontiers in Pharmacology, 13 [PMID:35392557] |
39. Lan Zhenwei, Zhang Ying, Sun Yue, Wang Lvhong, Huang Yuting, Cao Hui, Wang Shumei, Meng Jiang. (2021) Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS. Frontiers in Pharmacology, 12 [PMID:34955839] |
40. Li-Hua Liu,Cheng-Xiong Yang,Xiu-Ping Yan. (2016-12-13) Methacrylate-bonded covalent-organic framework monolithic columns for high performance liquid chromatography.. Journal of chromatography. A, 1479 (137-144). [PMID:27939601] |
41. Tingting Li,Bing Yang,Xuepeng Li,Jianrong Li,Guohua Zhao,Jianquan Kan. (2018-08-02) Quorum sensing system and influence on food spoilage in Pseudomonas fluorescens from turbot.. Journal of food science and technology, 55 ((8)): (3016-3025). [PMID:30065411] |
42. Jing Li,Li Xu,Zhi-Guo Shi. (2018-12-12) Waxberry-like hierarchically porous ethyl-bridged hybrid silica microsphere: A substrate for enzyme catalysis and high-performance liquid chromatography.. Journal of chromatography. A, 1587 (79-87). [PMID:30527847] |
43. Isam Karam,Ning Ma,Xi-Wang Liu,Shi-Hong Li,Xiao-Jun Kong,Jian-Yong Li,Ya-Jun Yang. (2015-08-21) Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia.. BMC veterinary research, 11 (217-217). [PMID:26289078] |
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21. Pei Jing, Yuling Luo, Yun Chen, Jiangbing Tan, Chunyan Liao, Shiyong Zhang. (2023) Aspirin-Loaded Cross-Linked Lipoic Acid Nanodrug Prevents Postoperative Tumor Recurrence by Residual Cancer Cell Killing and Inflammatory Microenvironment Improvement. BIOCONJUGATE CHEMISTRY, 34 (2): (366–376). [PMID:36626242] |
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29. Guo-Qi Zhang, Wei-Wu, Yu-Han Shi, Yang Zhao, Zhi-Hong Xu. (2023) Flow injection spectrophotometric determination total antioxidant capacity in human serum samples based on response surface methodology to optimize synthesized peroxidase-like activity carbon dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 284 (121832). [PMID:36088741] |
30. Peilin Zhang, Shiru He, Siqi Wu, Yi Li, Huiying Wang, Changyang Yan, Hua Yang, Ping Li. (2022) Discovering a Multi-Component Combination against Vascular Dementia from Danshen-Honghua Herbal Pair by Spectrum-Effect Relationship Analysis. Pharmaceuticals, 15 (9): (1073). [PMID:36145294] |
31. Guanghui Ren, Yan Ma, Xingjie Wang, Zhaodi Zheng, Guorong Li. (2022) Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY, 932 (175208). [PMID:35981603] |
32. Shuwei Cai, Xian Li, Shijie Pu, Xinyu Ma, Xianru He. (2023) Preparation of poly(acrylamide-co-Acrylonitrile) thermosensitivity microgel and control release of aspirin. International Journal of Polymeric Materials and Polymeric Biomaterials, 72 (14): (1142-1150). [PMID:] |
33. Xianming Zhang, Qinghua Yu, Ping Zhou, Shiyu Yang, Jiashan Xia, Tao Deng, Chao Yu. (2022) Blood-brain barrier penetrating carbon dots with intrinsic anti-inflammatory and drug-loading properties. Biomaterials Advances, 139 (212995). [PMID:35882144] |
34. Fangwei Yang, Cheng Wang, Hang Yu, Yahui Guo, Yuliang Cheng, Weirong Yao, Yunfei Xie. (2022) Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food. Food Bioscience, 49 (101842). [PMID:] |
35. Yingfei Wang, Junhui Zhou, Fengliang Wang, Yi Xie, Shengwei Liu, Zhimin Ao, Chuanhao Li. (2022) Hydrogen generation from photocatalytic treatment of wastewater containing pharmaceuticals and personal care products by Oxygen-doped crystalline carbon nitride. SEPARATION AND PURIFICATION TECHNOLOGY, 296 (121425). [PMID:] |
36. Wang Yulin, Li Yangyang, Luo Yiling, Zhou Kailian, Qiu Xiuzhen, Guo Huishi. (2022) A novel molecularly imprinted polymer material for the recognition of ochratoxin A. JOURNAL OF POLYMER RESEARCH, 29 (5): (1-11). [PMID:] |
37. Wu Yusheng, Qin Dongmiao, Meng Shuo, Zhang Chuqing, Deng Biyang. (2022) Carbon quantum dots with blue/near infrared emissions for ratiometric fluorescent lornoxicam sensing and bio-imaging. MICROCHIMICA ACTA, 189 (4): (1-11). [PMID:35347472] |
38. Wu Yue, Li Kuangyu, Zeng Maolin, Qiao Boyang, Zhou Benhong. (2022) Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute Inflammation. Frontiers in Pharmacology, 13 [PMID:35392557] |
39. Lan Zhenwei, Zhang Ying, Sun Yue, Wang Lvhong, Huang Yuting, Cao Hui, Wang Shumei, Meng Jiang. (2021) Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS. Frontiers in Pharmacology, 12 [PMID:34955839] |
40. Li-Hua Liu,Cheng-Xiong Yang,Xiu-Ping Yan. (2016-12-13) Methacrylate-bonded covalent-organic framework monolithic columns for high performance liquid chromatography.. Journal of chromatography. A, 1479 (137-144). [PMID:27939601] |
41. Tingting Li,Bing Yang,Xuepeng Li,Jianrong Li,Guohua Zhao,Jianquan Kan. (2018-08-02) Quorum sensing system and influence on food spoilage in Pseudomonas fluorescens from turbot.. Journal of food science and technology, 55 ((8)): (3016-3025). [PMID:30065411] |
42. Jing Li,Li Xu,Zhi-Guo Shi. (2018-12-12) Waxberry-like hierarchically porous ethyl-bridged hybrid silica microsphere: A substrate for enzyme catalysis and high-performance liquid chromatography.. Journal of chromatography. A, 1587 (79-87). [PMID:30527847] |
43. Isam Karam,Ning Ma,Xi-Wang Liu,Shi-Hong Li,Xiao-Jun Kong,Jian-Yong Li,Ya-Jun Yang. (2015-08-21) Regulation effect of Aspirin Eugenol Ester on blood lipids in Wistar rats with hyperlipidemia.. BMC veterinary research, 11 (217-217). [PMID:26289078] |