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Synonyms | aspirin|ACETYLSALICYLIC ACID|50-78-2|2-Acetoxybenzoic acid|2-(Acetyloxy)benzoic acid|Acetylsalicylate|O-Acetylsalicylic acid|o-Acetoxybenzoic acid|Acenterine|Acetophen|Acetosal|Acylpyrin|Easprin|Ecotrin|Salicylic acid acetate|Acetosalin|Aspirdrops|Polopir |
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Specifications & Purity | Moligand™, for plant cell culture, ≥99% |
Biochemical and Physiological Mechanisms | Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production |
Shipped In | Normal |
Grade | for plant cell culture, Moligand™ |
Action Type | CHANNEL BLOCKER, INHIBITOR |
Mechanism of action | Channel blocker of ASIC3;Inhibitor of COX-1;Inhibitor of COX-2 |
Product Description | Aspirin is an antiinflammatory compound that inhibits NFκB, cylooxygenase-1 (Cox-1), and cyclooxygenase-2 (Cox-2). NFκB is a transcription factor that plays an important role in the expression of cellular and viral genes, which regulate the inflammatory response and infection. Adhesion molecules IL-1 and IL-6 are genes regulated by NFκB. Along with sodium salicylate, aspirin has been shown to block the long terminal repeat from the human immunodeficiency virus and the Ig κ enhancer from NFκB dependent transcription. Research indicates that aspirin acts at a site downstream of glutamate receptors and blocks induction of NFκB mediated by glutamate. Additional studies suggest that aspirin and sodium salicylate specifically inhibit IKKβ, which results in the blocking of NFκB genes responsible for the inflammatory response. Aspirin has also been described to elevate extracellular adenosine levels, downregulate the expression and activity of inducible NOS, decrease the levels of adenosine triphosphate, act on multiple mitogen-activated protein kinase activities, and block the uncoupling of oxidative phosphorylation. Studies reveal that aspirin alters the equilibrium of Mcl-1/Noxa, giving rise to apoptosis of leukemia cells, independent of NFκB and MAPKs. |
ALogP | 1.2 |
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IUPAC Name | 2-acetyloxybenzoic acid |
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INCHI | InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12) |
InChi Key | BSYNRYMUTXBXSQ-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)OC1=CC=CC=C1C(=O)O |
Isomeric SMILES | CC(=O)OC1=CC=CC=C1C(=O)O |
WGK Germany | 1 |
RTECS | VO0700000 |
PubChem CID | 2244 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 180.16 |
Beilstein | 779271 |
Reaxy-Rn | 779271 |
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Lot Number | Certificate Type | Date | Item |
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C23151620 | Certificate of Analysis | Nov 28, 2022 | A118582 |
C23151625 | Certificate of Analysis | Nov 28, 2022 | A118582 |
C23151775 | Certificate of Analysis | Nov 28, 2022 | A118582 |
Solubility | Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml). |
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Sensitivity | Moisture sensitive. |
Flash Point(°F) | 446 °F |
Flash Point(°C) | 250℃ |
Melt Point(°C) | 136-140°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 1 |
RTECS | VO0700000 |
Reaxy-Rn | 779271 |
Class | 6.1 |
Merck Index | 851 |
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