Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A288225-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $144.90 | |
A288225-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $324.90 | |
A288225-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $590.90 | |
A288225-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,063.90 |
Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors
Synonyms | Q15633960 | ACIFRAN | Acifran (+)-form [MI] | Acifran (USAN/INN) | HY-107579 | Acifran (-)-form [MI] | B1X701S0MV | ACIFRAN [INN] | ACIFRAN [USAN] | AY-25712 | (S)-1(3-Bromophenyl)ethanamine | 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid | |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50values are 1.3 and 4.2μM respectively). Reduces serum triglycerides and circulating LDL-choles |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of HCA 2 receptor;Agonist of HCA 3 receptor |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid |
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INCHI | InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15) |
InChi Key | DFDGRKNOFOJBAJ-UHFFFAOYSA-N |
Canonical SMILES | CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2 |
Isomeric SMILES | CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2 |
PubChem CID | 51576 |
Molecular Weight | 218.21 |
PubChem CID | 51576 |
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ChEMBL Ligand | CHEMBL278488 |
BindingDB Ligand | 50208138 |
CAS Registry No. | 72420-38-3 |
Wikipedia | Acifran |
GPCRdb Ligand | acifran |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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E2306290 | Certificate of Analysis | Apr 03, 2023 | A288225 |
E2306294 | Certificate of Analysis | Apr 03, 2023 | A288225 |
E2306311 | Certificate of Analysis | Apr 03, 2023 | A288225 |
E2306313 | Certificate of Analysis | Apr 03, 2023 | A288225 |
Solubility | Solvent:ethanol, Max Conc. mg/mL: 21.82, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 21.82, Max Conc. mM: 100 |
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