Acifran - 98%, high purity , CAS No.72420-38-3, Agonist of HCA 2 receptor;Agonist of HCA 3 receptor

Item Number
A288225
Grouped product items
SKUSizeAvailabilityPrice Qty
A288225-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$144.90
A288225-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$324.90
A288225-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$590.90
A288225-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,063.90

Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors

Basic Description

SynonymsQ15633960 | ACIFRAN | Acifran (+)-form [MI] | Acifran (USAN/INN) | HY-107579 | Acifran (-)-form [MI] | B1X701S0MV | ACIFRAN [INN] | ACIFRAN [USAN] | AY-25712 | (S)-1(3-Bromophenyl)ethanamine | 5-Methyl-4-oxo-5-phenyl-4,5-dihydro-furan-2-carboxylic acid |
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsHypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50values are 1.3 and 4.2μM respectively). Reduces serum triglycerides and circulating LDL-choles
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of HCA 2 receptor;Agonist of HCA 3 receptor

Associated Targets(Human)

HCAR2 Tclin Hydroxycarboxylic acid receptor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HCAR3 Tchem Hydroxycarboxylic acid receptor 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HCAR3 Tchem HM74 nicotinic acid GPCR (353 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
INCHI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
InChi Key DFDGRKNOFOJBAJ-UHFFFAOYSA-N
Canonical SMILES CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2
Isomeric SMILES CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2
PubChem CID 51576
Molecular Weight 218.21

Certificates

Certificate of Analysis(COA)

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4 results found

Lot NumberCertificate TypeDateItem
E2306290Certificate of AnalysisApr 03, 2023 A288225
E2306294Certificate of AnalysisApr 03, 2023 A288225
E2306311Certificate of AnalysisApr 03, 2023 A288225
E2306313Certificate of AnalysisApr 03, 2023 A288225

Chemical and Physical Properties

SolubilitySolvent:ethanol, Max Conc. mg/mL: 21.82, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 21.82, Max Conc. mM: 100

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