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Acifran - 98%, high purity , CAS No.72420-38-3, Agonist of HCA 2 receptor;Agonist of HCA 3 receptor

Moligand™
≥98%

CAS#: 72420-38-3
Formula: C₁₂H₁₀O₄
Molecular Weight: 218.21
PubChem CID: 51576

Item Number

A288225

Grouped product items
SKU	Size	Availability	Price
A288225-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$144.90
A288225-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$324.90
A288225-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$590.90
A288225-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,063.90

Hypolipidemic agent; agonist for the GPR109A (HM74A) and GPR109B receptors

View related series

HCA2 receptor Agonist HCA3 receptor Agonist

Basic Description

Synonyms	ACIFRAN\|72420-38-3\|Reductol\|Acifranum\|AY-25712\|AY 25712\|Acifran, (+)-\|Acifran, (-)-\|AY-25,712\|Acifran (+)-form [MI]\|Acifran (-)-form [MI]\|4,5-Dihydro-5-methyl-4-oxo-5-phenyl-2-furancarboxylic acid\|FP3LLW01BL\|5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid\|
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Hypolipidemic agent. Exhibits higher potency than nicotinic acid and clofibrate. Full and potent agonist at the human orphan GPCR HM74A/GPR109A and GPR109B (EC50values are 1.3 and 4.2μM respectively). Reduces serum triglycerides and circulating LDL-choles
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of HCA 2 receptor;Agonist of HCA 3 receptor

Associated Targets

HCAR2 Tclin Hydroxycarboxylic acid receptor 2 0 Activities

Discover Target: HCAR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCAR3 Tchem Hydroxycarboxylic acid receptor 3 0 Activities

Discover Target: HCAR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid
INCHI	InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
InChi Key	DFDGRKNOFOJBAJ-UHFFFAOYSA-N
Canonical SMILES	CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2
Isomeric SMILES	CC1(C(=O)C=C(O1)C(=O)O)C2=CC=CC=C2
PubChem CID	51576
Molecular Weight	218.21

PubChem CID

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

Wikipedia

GPCRdb Ligand

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4 results found

Lot Number	Certificate Type	Date	Item
E2306290	Certificate of Analysis	Apr 03, 2023	A288225
E2306294	Certificate of Analysis	Apr 03, 2023	A288225
E2306311	Certificate of Analysis	Apr 03, 2023	A288225
E2306313	Certificate of Analysis	Apr 03, 2023	A288225

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