Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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A113142-5mg | 5mg | In stock | $103.90 | |
A113142-25mg | 25mg | In stock | $412.90 | |
A113142-100mg | 100mg | In stock | $1,330.90 |
Nucleic acid and protein synthesis inhibitor
Synonyms | Dactinomicina | DTXSID9020031 | Glycopeptide, 4a | GNF-Pf-2290 | ACT D | ACTINOMYCIN D [JAN] | Actinomycin I | Q7277486 | ACT (antibiotic) | AD (VAN) | Dactinomicina (INN-Spanish) | Dactinomycinum (INN-Latin) | GTPL5664 | 2-amino-4,6-dimethyl-3-oxo-1-N,9- |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Nucleic acid and protein synthesis inhibitor. Intercalates DNA, stabilizes topoisomerases I and II and inhibits transcription. Antibacterial and antitumor agent. Active in vivo and in vitro . |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 3.8 |
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IUPAC Name | 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide |
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INCHI | InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1 |
InChi Key | RJURFGZVJUQBHK-IIXSONLDSA-N |
Canonical SMILES | CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C |
Isomeric SMILES | C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C |
PubChem CID | 457193 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 1255.438 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2414138 | Certificate of Analysis | Jun 16, 2022 | A113142 |
I2214478 | Certificate of Analysis | Jun 16, 2022 | A113142 |
I2214479 | Certificate of Analysis | Jun 16, 2022 | A113142 |
I2214481 | Certificate of Analysis | Jun 16, 2022 | A113142 |
B2325201 | Certificate of Analysis | Mar 09, 2022 | A113142 |
C2224089 | Certificate of Analysis | Mar 09, 2022 | A113142 |
C2224090 | Certificate of Analysis | Mar 09, 2022 | A113142 |
C2224092 | Certificate of Analysis | Mar 09, 2022 | A113142 |
Solubility | It is soluble ino 50 mM in DMSO. |
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Sensitivity | Light sensitive.Hygroscopic. |
Melt Point(°C) | 251-253°C |
Pictogram(s) | GHS06, GHS08 |
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Signal | Danger |
Hazard Statements | H300:Fatal if swallowed H360:May damage fertility or the unborn child H350:May cause cancer |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice. |
Class | 6.1 |
1. Chen Guo, Mingyi Yu, Jinghua Liu, Zhe Jia, Hui Liu, Shaozhen Zhao. (2023) Molecular mechanism of Wilms tumor 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1. JOURNAL OF DRUG TARGETING, [PMID:38153328] |
2. Wei Liu, Hui Zeng. (2024) IGF2BP2 attenuates intestinal epithelial cell ferroptosis in colitis by stabilizing m6A-modified GPX4 mRNA. CYTOKINE, 173 (1): (156388). [PMID:38039694] |
3. Fan Hairui, Zhou Dongjie, Zhang Xiaomei, Jiang Min, Kong Xiang, Xue Tongmin, Gao Lingling, Lu Dan, Tao Chenyue, Wang Liping. (2023) hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis. MOLECULAR HUMAN REPRODUCTION, 29 (11): [PMID:37882757] |
4. Zhang Yang, Chao Fengmei, Lv Lihua, Li Ming, Shen Zuojun. (2023) Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, (1-18). [PMID:37639013] |
5. Wei-Hang Zhu, Jie Chen, Run-Kai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu-Qing Pang, Bo Hu, Yang Yang, Xing Li. (2023) Erythroid-transdifferentiated myeloid cells promote portal vein tumor thrombus in hepatocellular carcinoma. Theranostics, 13 (13): ( 4316–4332). [PMID:37649603] |
6. Jing Zhang, Kairu Liu, Xiaojuan Duan, Xuhao Wang, Wupeng Ge, Wenping Jin. (2023) Restoration of Choujiu Koji and evaluation of its brewing performance. LWT-FOOD SCIENCE AND TECHNOLOGY, 183 (114933). [PMID:] |
7. Fei Sun, Cheng An, Can Liu, Ying Hu, Yue Su, Zhixiang Guo, Hong Che, Shenglin Ge. (2023) FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia–reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of β-catenin. FASEB JOURNAL, 37 (6): (e22964). [PMID:37199660] |
8. Zhiyong Guo, Zilin Wang, Yige Liu, Hao Wu, Qiaoyu Zhang, Jing Han, Jiannan Liu, Chenping Zhang. (2023) Carbon Dots from Lycium barbarum Attenuate Radiation-Induced Bone Injury by Inhibiting Senescence via METTL3/Clip3 in an m6A-Dependent Manner. ACS Applied Materials & Interfaces, 15 (17): (20726–20741). [PMID:37088945] |
9. Yang Liu, Du Xing, Wang Siqi, Lin Chenggang, Li Qiqi, Li Qifa. (2023) A regulatory network controlling ovarian granulosa cell death. Cell Death Discovery, 9 (1): (1-11). [PMID:36806197] |
10. Zhang Shouyi, Lv Chengcheng, Niu Yichen, Li Changqi, Li Xiuming, Shang Yu, Zhang Yunchao, Zhang Yue, Zhang Yong, Zeng Yu. (2023) RBM3 suppresses stemness remodeling of prostate cancer in bone microenvironment by modulating N6-methyladenosine on CTNNB1 mRNA. Cell Death & Disease, 14 (2): (1-14). [PMID:36750551] |
11. Lifang Liu, Bingkai Han, Lixia Liu, Hongying Cui, Hao Liu, Rui Jia, Xiaoyan Zhang, Xiaoxiao Lu. (2023) Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells. Reproductive Biology, 23 (100704). [PMID:36481473] |
12. Jin-Xin Yu, Yan-Min Hui, Jun-Ao Xue, Jia-Bao Qu, Si-Quan Ling, Wei Wang, Xin-Nian Zeng, Jia-Li Liu. (2022) Formation characteristics of long-term memory in Bactrocera dorsalis. Insect Science, 30 (3): (829-843). [PMID:36151856] |
13. Jiayu Lin, Yuting Xiang, Jiana Huang, Haitao Zeng, Yanyan Zeng, Jiawen Liu, Taibao Wu, Qiqi Liang, Xiaoyan Liang, Jingjie Li, Chuanchuan Zhou. (2022) NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation.. Frontiers in Endocrinology, 13 (907286-907286). [PMID:35937804] |
1. Xia P et al.. (2018) A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.. Immunity, 48 (4): (688-701.e7). [PMID:29625897] |
2. Liu J et al.. (2019) CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1a-Mediated Glycolysis.. Immunity, 50 (3): (600-615.e15). [PMID:30824325] |
3. Lu M et al.. (2018) CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1a.. Cell Death Dis, 9 (10): (1046). [PMID:30315244] |
4. Huang X et al.. (2019) Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.. Mol Cancer, 18 (71). [PMID:30927924] |
5. Li B et al.. (2021) c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.. Cell Death Dis, 12 (11): (1006). [PMID:34707111] |
6. Zhu L et al.. (2019) Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer.. Cell Death Dis, 10 (6): (383). [PMID:31097692] |
7. Wang C et al.. (2019) Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.. Proc Natl Acad Sci U S A, 116 (29): (14620-14629). [PMID:31262817] |
8. Xiong J et al.. (2017) MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.. Blood Cancer J, 7 (7): (e0). [PMID:28686226] |
9. Zhu R et al.. (2022) Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-?B pathway.. Genes Dis, 9 (2): (494-509). [PMID:35224163] |
10. Liang YX et al.. (2020) Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization.. Reproduction, 160 (4): (491-500). [PMID:32817586] |
11. Chen LY et al.. (2020) The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1a translation.. Mol Cancer, 19 (164). [PMID:33225938] |
12. Shen H et al.. (2021) ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression.. Cell Death Dis, 12 (4): (349). [PMID:33824282] |
13. Chen Guo, Mingyi Yu, Jinghua Liu, Zhe Jia, Hui Liu, Shaozhen Zhao. (2023) Molecular mechanism of Wilms tumor 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1. JOURNAL OF DRUG TARGETING, [PMID:38153328] |
14. Wei Liu, Hui Zeng. (2024) IGF2BP2 attenuates intestinal epithelial cell ferroptosis in colitis by stabilizing m6A-modified GPX4 mRNA. CYTOKINE, 173 (1): (156388). [PMID:38039694] |
15. Fan Hairui, Zhou Dongjie, Zhang Xiaomei, Jiang Min, Kong Xiang, Xue Tongmin, Gao Lingling, Lu Dan, Tao Chenyue, Wang Liping. (2023) hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis. MOLECULAR HUMAN REPRODUCTION, 29 (11): [PMID:37882757] |
16. Zhang Yang, Chao Fengmei, Lv Lihua, Li Ming, Shen Zuojun. (2023) Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, (1-18). [PMID:37639013] |
17. Wei-Hang Zhu, Jie Chen, Run-Kai Huang, Yuan Zhang, Ze-Xuan Huang, Xiu-Qing Pang, Bo Hu, Yang Yang, Xing Li. (2023) Erythroid-transdifferentiated myeloid cells promote portal vein tumor thrombus in hepatocellular carcinoma. Theranostics, 13 (13): ( 4316–4332). [PMID:37649603] |
18. Jing Zhang, Kairu Liu, Xiaojuan Duan, Xuhao Wang, Wupeng Ge, Wenping Jin. (2023) Restoration of Choujiu Koji and evaluation of its brewing performance. LWT-FOOD SCIENCE AND TECHNOLOGY, 183 (114933). [PMID:] |
19. Fei Sun, Cheng An, Can Liu, Ying Hu, Yue Su, Zhixiang Guo, Hong Che, Shenglin Ge. (2023) FTO represses NLRP3-mediated pyroptosis and alleviates myocardial ischemia–reperfusion injury via inhibiting CBL-mediated ubiquitination and degradation of β-catenin. FASEB JOURNAL, 37 (6): (e22964). [PMID:37199660] |
20. Zhiyong Guo, Zilin Wang, Yige Liu, Hao Wu, Qiaoyu Zhang, Jing Han, Jiannan Liu, Chenping Zhang. (2023) Carbon Dots from Lycium barbarum Attenuate Radiation-Induced Bone Injury by Inhibiting Senescence via METTL3/Clip3 in an m6A-Dependent Manner. ACS Applied Materials & Interfaces, 15 (17): (20726–20741). [PMID:37088945] |
21. Yang Liu, Du Xing, Wang Siqi, Lin Chenggang, Li Qiqi, Li Qifa. (2023) A regulatory network controlling ovarian granulosa cell death. Cell Death Discovery, 9 (1): (1-11). [PMID:36806197] |
22. Zhang Shouyi, Lv Chengcheng, Niu Yichen, Li Changqi, Li Xiuming, Shang Yu, Zhang Yunchao, Zhang Yue, Zhang Yong, Zeng Yu. (2023) RBM3 suppresses stemness remodeling of prostate cancer in bone microenvironment by modulating N6-methyladenosine on CTNNB1 mRNA. Cell Death & Disease, 14 (2): (1-14). [PMID:36750551] |
23. Lifang Liu, Bingkai Han, Lixia Liu, Hongying Cui, Hao Liu, Rui Jia, Xiaoyan Zhang, Xiaoxiao Lu. (2023) Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells. Reproductive Biology, 23 (100704). [PMID:36481473] |
24. Jin-Xin Yu, Yan-Min Hui, Jun-Ao Xue, Jia-Bao Qu, Si-Quan Ling, Wei Wang, Xin-Nian Zeng, Jia-Li Liu. (2022) Formation characteristics of long-term memory in Bactrocera dorsalis. Insect Science, 30 (3): (829-843). [PMID:36151856] |
25. Jiayu Lin, Yuting Xiang, Jiana Huang, Haitao Zeng, Yanyan Zeng, Jiawen Liu, Taibao Wu, Qiqi Liang, Xiaoyan Liang, Jingjie Li, Chuanchuan Zhou. (2022) NAT10 Maintains OGA mRNA Stability Through ac4C Modification in Regulating Oocyte Maturation.. Frontiers in Endocrinology, 13 (907286-907286). [PMID:35937804] |