Skip to the beginning of the images gallery

Actinomycin D - 98%, high purity , CAS No.50-76-0

≥98%

CAS#: 50-76-0
Formula: C₆₂H₈₆N₁₂O₁₆
Molecular Weight: 1255.438
MDL number: MFCD00005033
PubChem CID: 457193

Item Number

A113142

Grouped product items
SKU	Size	Availability	Price
A113142-5mg	5mg	In stock	$103.90
A113142-25mg	25mg	In stock	$412.90
A113142-100mg	100mg	In stock	$1,330.90

Nucleic acid and protein synthesis inhibitor

Basic Description

Synonyms	DACTINOMYCIN\|actinomycin D\|Actinomycin C1\|Actinomycin IV\|Meractinomycin\|50-76-0\|Cosmegen\|Actinomycin I1\|Dactinomycinum\|Cosmegen Lyovac\|Lyovac-Cosmegen\|Chounghwamycin B\|ActD\|Actinomycin X1\|Dilactone actinomycin D acid\|Oncostatin K\|Dactinomicina\|Dactinomyci
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice

Names and Identifiers

IUPAC Name	2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
INCHI	InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
InChi Key	RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES	CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
Isomeric SMILES	C[C@@H]1[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N(CC(=O)N([C@H](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)N[C@H]6[C@H](OC(=O)[C@@H](N(C(=O)CN(C(=O)[C@@H]7CCCN7C(=O)[C@H](NC6=O)C(C)C)C)C)C(C)C)C)N)C
PubChem CID	457193
UN Number	2811
Packing Group	I
Molecular Weight	1255.438

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

8 results found

Lot Number	Certificate Type	Date	Item
E2414138	Certificate of Analysis	Jun 16, 2022	A113142
I2214478	Certificate of Analysis	Jun 16, 2022	A113142
I2214479	Certificate of Analysis	Jun 16, 2022	A113142
I2214481	Certificate of Analysis	Jun 16, 2022	A113142
B2325201	Certificate of Analysis	Mar 09, 2022	A113142
C2224089	Certificate of Analysis	Mar 09, 2022	A113142
C2224090	Certificate of Analysis	Mar 09, 2022	A113142
C2224092	Certificate of Analysis	Mar 09, 2022	A113142

Solubility

It is soluble ino 50 mM in DMSO.

Sensitivity

Light sensitive.Hygroscopic.

Melt Point(°C)

251-253°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H300:Fatal if swallowed H360:May damage fertility or the unborn child H350:May cause cancer
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
Class	6.1

References

1. Xia P et al.. (2018) A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.. Immunity, 48 (4): (688-701.e7). [PMID:29625897]
2. Liu J et al.. (2019) CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1a-Mediated Glycolysis.. Immunity, 50 (3): (600-615.e15). [PMID:30824325]
3. Lu M et al.. (2018) CIRBP is a novel oncogene in human bladder cancer inducing expression of HIF-1a.. Cell Death Dis, 9 (10): (1046). [PMID:30315244]
4. Huang X et al.. (2019) Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.. Mol Cancer, 18 (71). [PMID:30927924]
5. Li B et al.. (2021) c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNA.. Cell Death Dis, 12 (11): (1006). [PMID:34707111]
6. Zhu L et al.. (2019) Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancer.. Cell Death Dis, 10 (6): (383). [PMID:31097692]
7. Wang C et al.. (2019) Long noncoding RNA EMS connects c-Myc to cell cycle control and tumorigenesis.. Proc Natl Acad Sci U S A, 116 (29): (14620-14629). [PMID:31262817]
8. Xiong J et al.. (2017) MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma.. Blood Cancer J, 7 (7): (e0). [PMID:28686226]
9. Zhu R et al.. (2022) Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-?B pathway.. Genes Dis, 9 (2): (494-509). [PMID:35224163]
10. Liang YX et al.. (2020) Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization.. Reproduction, 160 (4): (491-500). [PMID:32817586]
11. Chen LY et al.. (2020) The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1a translation.. Mol Cancer, 19 (164). [PMID:33225938]
12. Shen H et al.. (2021) ZEB1-induced LINC01559 expedites cell proliferation, migration and EMT process in gastric cancer through recruiting IGF2BP2 to stabilize ZEB1 expression.. Cell Death Dis, 12 (4): (349). [PMID:33824282]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.