Adefovir - 98% (HPLC), high purity , DNA polymerase/reverse transcriptase inhibitor, CAS No.106941-25-7, DNA polymerase/reverse transcriptase inhibitor

Item Number

A165714

• Synonyms: Phosphonic acid, ((2-6-amino-9H-purin-9-YL)ethoxy)methyl | ADEFOVIR [WHO-DD] | DB13868 | ((2-6-amino-9H-purin-9-yl) ethoxy) methyl)- phosphonic acid. | 106941-25-7 (free acid) | BA166179 | HY-B1826 | AC-012 | GS-0393 | 2-(6-aminopurin-9-yl)ethoxymethylpho
• Specifications & Purity: ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Nucleotide analog reverse transcriptase inhibitor (K i = 100 nM, HBV DNA polymerase). Antiviral agent. cAMP analog. MRP4 substrate. Shows antireplication effects against hepatitis B in vivo. Orally active.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: DNA polymerase/reverse transcriptase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.