Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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C107047-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $9.90 | |
C107047-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $12.90 | |
C107047-1g | 1g | In stock | $15.90 | |
C107047-5g | 5g | In stock | $445.90 | |
C107047-25g | 25g | In stock | $2,004.90 |
Second messenger. PKA activator.
Synonyms | cAMP | bmse000071 | cAMP | Cyclic Monophosphate, Adenosine | 3',5'-cyclic AMP | Adenosine 3',5'-cyclic phosphate | ADENOSINUM CYCLOPHOSPHORICUM | Cyclic AMP | Epitope ID:137352 | Adenosine 3',5'-cyclophosphate | Adenosine Cyclic 3',5' Monophosphate | ADEN |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of CNGA2;Activator of CNGA3;Activator of HCN1;Activator of HCN2;Activator of protein kinase A |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Application: Adenosine 3′,5′-cyclic monophosphate has been used: |
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IUPAC Name | (4aR,6R,7R,7aS)-6-(6-aminopurin-9-yl)-2-hydroxy-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol |
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INCHI | InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 |
InChi Key | IVOMOUWHDPKRLL-KQYNXXCUSA-N |
Canonical SMILES | C1C2C(C(C(O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O |
Isomeric SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(O1)O |
WGK Germany | 3 |
RTECS | AU7357600 |
Alternate CAS | 60-92-4,37839-81-9 (mono-hydrochloride salt) |
PubChem CID | 6076 |
MeSH Entry Terms | 3',5'-Monophosphate, Adenosine Cyclic;Adenosine Cyclic 3',5' Monophosphate;Adenosine Cyclic 3',5'-Monophosphate;Adenosine Cyclic 3,5 Monophosphate;Adenosine Cyclic Monophosphate;Adenosine Cyclic-3',5'-Monophosphate;AMP, Cyclic;Cyclic 3',5'-Monophosphate, |
Molecular Weight | 329.21 |
Beilstein | 52645 |
Reaxy-Rn | 52645 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2026124 | Certificate of Analysis | Aug 16, 2024 | C107047 |
G2403035 | Certificate of Analysis | Oct 20, 2023 | C107047 |
K2301151 | Certificate of Analysis | Oct 20, 2023 | C107047 |
K2301152 | Certificate of Analysis | Oct 20, 2023 | C107047 |
K2301153 | Certificate of Analysis | Oct 20, 2023 | C107047 |
K2301154 | Certificate of Analysis | Oct 20, 2023 | C107047 |
G2307580 | Certificate of Analysis | Jul 20, 2022 | C107047 |
I2220185 | Certificate of Analysis | Jul 20, 2022 | C107047 |
I2220186 | Certificate of Analysis | Jul 20, 2022 | C107047 |
I2220187 | Certificate of Analysis | Jul 20, 2022 | C107047 |
Solubility | H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.);Solube in water: 10 mg/mL pH of aqueous solution is approx. 3.0.; |
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Sensitivity | heat sensitive |
Specific Rotation[α] | -50° (C=0.7,H2O) |
Melt Point(°C) | 260°C |
Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H314:Causes severe skin burns and eye damage H318:Causes serious eye damage |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | AU7357600 |
Reaxy-Rn | 52645 |
Merck Index | 2708 |
1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin. (2023) A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation. ANALYTICAL SCIENCES, (1-7). [PMID:37843729] [10.1007/s44211-023-00430-5] |
2. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv. (2023) Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 230 (123266). [PMID:36646351] [10.1016/j.ijbiomac.2023.123266] |
3. Ru Li, Xuan Zou, Pan Luan, Xiaokun Liu, Ning Wang, Qian Wang, Huashi Guan, Zhe Xu. (2022) Direct Determination of Enzymes in Dried Blood Spots by High-Performance Liquid Chromatography – Mass Spectrometry (HPLC-MS) for the Screening of Antithrombotic Agents. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2022.2053700] |
4. Li-na Ji, Shan Wu, Dan-qing Fu, Si-jia Fang, Guan-qun Xie, Yong-sheng Fan, Jie Bao. (2022) Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice. JOURNAL OF ETHNOPHARMACOLOGY, 284 (114815). [PMID:34763039] [10.1016/j.jep.2021.114815] |
5. Wenfeng Zhou, Yuan Rao, Wei Zhuang, Lei Ge, Rijia Lin, Ting Tang, Jinglan Wu, Ming Li, Pengpeng Yang, Chenjie Zhu, Hao Wang, Hanjie Ying. (2021) Improved enzymatic activity by oriented immobilization on graphene oxide with tunable surface heterogeneity. COMPOSITES PART B-ENGINEERING, 216 (108788). [PMID:] [10.1016/j.compositesb.2021.108788] |
6. Sun Chao, Zhao Shiyu, Qu Fei, Han Wenli, You Jinmao. (2020) Determination of adenosine triphosphate based on the use of fluorescent terbium(III) organic frameworks and aptamer modified gold nanoparticles. MICROCHIMICA ACTA, 187 (1): (1-9). [PMID:31814046] [10.1007/s00604-019-4019-z] |
7. K. Xu, J.L. Wang, M.P. Chu, C. Jia. (2019) Activity of coumarin against Candida albicans biofilms. JOURNAL DE MYCOLOGIE MEDICALE, 29 (28). [PMID:30606640] [10.1016/j.mycmed.2018.12.003] |
8. Qu Fei, Sun Chao, Lv Xiaoxia, You Jinmao. (2018) A terbium-based metal-organic framework@gold nanoparticle system as a fluorometric probe for aptamer based determination of adenosine triphosphate. MICROCHIMICA ACTA, 185 (8): (1-8). [PMID:29978289] [10.1007/s00604-018-2888-1] |
9. Chen Zhao, Yan Yang, Linfang Wei, Qinghua Guo, Hao Fang, Shaolin Chen, Qiang Hua. (2017) Simultaneous determination of intracellular nucleotides and coenzymes in Yarrowia lipolytica producing lipid and lycopene by capillary zone electrophoresis. JOURNAL OF CHROMATOGRAPHY A, 1514 (120). [PMID:28760603] [10.1016/j.chroma.2017.07.074] |
1. Lai Liang, Zhang Mengyun, Liu Chusheng, Qu Jiahuan, Xu Dongsheng, Jiang Zhengjin. (2023) A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation. ANALYTICAL SCIENCES, (1-7). [PMID:37843729] [10.1007/s44211-023-00430-5] |
2. Qiuyang Huang, Xiaoling Zang, Zhiwei Zhang, Hang Yu, Baoyan Ding, Zhuangzhuang Li, Simin Cheng, Xin Zhang, Mustafa R.K. Ali, Xue Qiu, Zhihua Lv. (2023) Study on endogenous inhibitors against PD-L1: cAMP as a potential candidate. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 230 (123266). [PMID:36646351] [10.1016/j.ijbiomac.2023.123266] |
3. Ru Li, Xuan Zou, Pan Luan, Xiaokun Liu, Ning Wang, Qian Wang, Huashi Guan, Zhe Xu. (2022) Direct Determination of Enzymes in Dried Blood Spots by High-Performance Liquid Chromatography – Mass Spectrometry (HPLC-MS) for the Screening of Antithrombotic Agents. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2022.2053700] |
4. Li-na Ji, Shan Wu, Dan-qing Fu, Si-jia Fang, Guan-qun Xie, Yong-sheng Fan, Jie Bao. (2022) Jieduquyuziyin Prescription alleviates hepatic gluconeogenesis via PI3K/Akt/PGC-1α pathway in glucocorticoid-induced MRL/lpr mice. JOURNAL OF ETHNOPHARMACOLOGY, 284 (114815). [PMID:34763039] [10.1016/j.jep.2021.114815] |
5. Wenfeng Zhou, Yuan Rao, Wei Zhuang, Lei Ge, Rijia Lin, Ting Tang, Jinglan Wu, Ming Li, Pengpeng Yang, Chenjie Zhu, Hao Wang, Hanjie Ying. (2021) Improved enzymatic activity by oriented immobilization on graphene oxide with tunable surface heterogeneity. COMPOSITES PART B-ENGINEERING, 216 (108788). [PMID:] [10.1016/j.compositesb.2021.108788] |
6. Sun Chao, Zhao Shiyu, Qu Fei, Han Wenli, You Jinmao. (2020) Determination of adenosine triphosphate based on the use of fluorescent terbium(III) organic frameworks and aptamer modified gold nanoparticles. MICROCHIMICA ACTA, 187 (1): (1-9). [PMID:31814046] [10.1007/s00604-019-4019-z] |
7. K. Xu, J.L. Wang, M.P. Chu, C. Jia. (2019) Activity of coumarin against Candida albicans biofilms. JOURNAL DE MYCOLOGIE MEDICALE, 29 (28). [PMID:30606640] [10.1016/j.mycmed.2018.12.003] |
8. Qu Fei, Sun Chao, Lv Xiaoxia, You Jinmao. (2018) A terbium-based metal-organic framework@gold nanoparticle system as a fluorometric probe for aptamer based determination of adenosine triphosphate. MICROCHIMICA ACTA, 185 (8): (1-8). [PMID:29978289] [10.1007/s00604-018-2888-1] |
9. Chen Zhao, Yan Yang, Linfang Wei, Qinghua Guo, Hao Fang, Shaolin Chen, Qiang Hua. (2017) Simultaneous determination of intracellular nucleotides and coenzymes in Yarrowia lipolytica producing lipid and lycopene by capillary zone electrophoresis. JOURNAL OF CHROMATOGRAPHY A, 1514 (120). [PMID:28760603] [10.1016/j.chroma.2017.07.074] |