Basic Description

Synonyms	987-65-5 \| ATP disodium salt \| Adenosine triphosphate disodium \| ATP disodium \| Adenosine 5'-triphosphate disodium salt \| Adetide \| Disodium adenosine triphosphate \| Disodium ATP \| Adenosine 5'-Triphosphate, disodium salt \| Triphosadenine \| Adetphos \| Triadesin A \| Disodium aden
Specifications & Purity	10mM in Water
Biochemical and Physiological Mechanisms	P2 purinoceptor agonist.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Adenosine 5'-Triphosphate, disodium salt is a p2 purinergic (P2X and P2Y) agonist that increases Ca2+-activated K+ channel activity. It has been found to induce a release of prostoglandin D2 and histamine from rat peritoneal mast cells in a dose-dependent manner.

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	disodium;[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate
INCHI	InChI=1S/C10H16N5O13P3.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
InChi Key	TTWYZDPBDWHJOR-IDIVVRGQSA-L
Canonical SMILES	C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O)N.[Na+].[Na+]
Isomeric SMILES	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O)N.[Na+].[Na+]
PubChem CID	13803
Molecular Weight	551.15

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Melt Point(°C)	188-190°C

Citations of This Product

1. Ting Liu, Ling Wang, Yang Yu, Zhuo Zhang, Zelong Duan, Yawen Li, Chencan Li. (2024) Adenosine Triphosphatase-Stabilized ZIF-67 as Peroxidase Mimic for Rapid Detection of Glutathione. INORGANIC CHEMISTRY COMMUNICATIONS, 159 (1): (111705). [PMID:14612514]
2. Ting Zeng, Jie Yin, Ziwen Liu, Zhaoxing Li, Yu Zhang, Yang Lv, Mei-Ling Lu, Min Luo, Meirong Chen, Yibei Xiao. (2023) Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system. Cell Reports, 42 (112698). [PMID:37379212]
3. Hong Liu, Xuliang Yang, Bo Huang, Hongxiang Liu. (2023) A universal approach for synthesis of copper nanoclusters templated by G-rich oligonucleotide sequences and their applications in sensing. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 297 (122740). [PMID:37080047]
4. Minglei Tao, Shengzhi Liu, Yaohan Li, Amin Liu, Zijian Sun, Vinesh Maharaj, Shouxin Li, Jingkui Tian, Wei Zhu. (2023) Comprehensive multi-omics analysis reveals the importance of CtCOSY in the energy metabolism and coumarin biosynthesis in Clematis terniflora DC. INDUSTRIAL CROPS AND PRODUCTS, 195 (116444). [PMID:]
5. Yue Xin, Dun Zhang, Yan Zeng, Yingwen Wang, Peng Qi. (2023) A dual-emission ratiometric fluorescent sensor based on copper nanoclusters encapsulated in zeolitic imidazolate framework-90 for rapid detection and imaging of adenosine triphosphate. Analytical Methods, 15 (6): (788-796). [PMID:36691974]
6. Yue Xin, Dun Zhang, Yan Zeng, Peng Qi. (2023) An abiotic carbon dots@ ZIF-90 fluorescent probe for rapid and reliable detection of adenosine triphosphate. ANALYTICAL BIOCHEMISTRY, 663 (115021). [PMID:36539047]
7. Jinling Xu, Qi Lv, Shumin Pan, Huanhuan Qiu, Yu Liao, Ming Zhou, Weijie Li, Caiyan Li, Pan Zhang, Yujian Li, Guanglin Xu, Qingfeng Yu. (2022) M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 933 (175261). [PMID:36100126]
8. Jiulong Zhang, Xiaoyan Sun, Lin Liu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao. (2022) Tumor-permeated ATP-based size-controllable immunogenic cell death amplifier remodel immunosuppressive microenvironment to boost cancer immunotherapy. Applied Materials Today, 28 (101518). [PMID:]
9. Jiulong Zhang, Xiaoyan Sun, Xiufeng Zhao, Chunrong Yang, Menghao Shi, Benzhuo Zhang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao. (2022) Combining immune checkpoint blockade with ATP-based immunogenic cell death amplifier for cancer chemo-immunotherapy. Acta Pharmaceutica Sinica B, 12 (3694). [PMID:36176905]
10. Jiulong Zhang, Xiaoyan Sun, Xiufeng Zhao, Lin Liu, Xin Cheng, Chunrong Yang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao. (2022) Watson–Crick Base Pairing-Inspired Laser/GSH Activatable miRNA-Coordination Polymer Nanoplexes for Combined Cancer Chemo-Immuno-Photothermal Therapy. ACS Applied Materials & Interfaces, 14 (18): (20762–20777). [PMID:35476413]

References

1. Ting Liu, Ling Wang, Yang Yu, Zhuo Zhang, Zelong Duan, Yawen Li, Chencan Li. (2024) Adenosine Triphosphatase-Stabilized ZIF-67 as Peroxidase Mimic for Rapid Detection of Glutathione. INORGANIC CHEMISTRY COMMUNICATIONS, 159 (1): (111705). [PMID:14612514]
2. Ting Zeng, Jie Yin, Ziwen Liu, Zhaoxing Li, Yu Zhang, Yang Lv, Mei-Ling Lu, Min Luo, Meirong Chen, Yibei Xiao. (2023) Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system. Cell Reports, 42 (112698). [PMID:37379212]
3. Hong Liu, Xuliang Yang, Bo Huang, Hongxiang Liu. (2023) A universal approach for synthesis of copper nanoclusters templated by G-rich oligonucleotide sequences and their applications in sensing. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 297 (122740). [PMID:37080047]
4. Minglei Tao, Shengzhi Liu, Yaohan Li, Amin Liu, Zijian Sun, Vinesh Maharaj, Shouxin Li, Jingkui Tian, Wei Zhu. (2023) Comprehensive multi-omics analysis reveals the importance of CtCOSY in the energy metabolism and coumarin biosynthesis in Clematis terniflora DC. INDUSTRIAL CROPS AND PRODUCTS, 195 (116444). [PMID:]
5. Yue Xin, Dun Zhang, Yan Zeng, Yingwen Wang, Peng Qi. (2023) A dual-emission ratiometric fluorescent sensor based on copper nanoclusters encapsulated in zeolitic imidazolate framework-90 for rapid detection and imaging of adenosine triphosphate. Analytical Methods, 15 (6): (788-796). [PMID:36691974]
6. Yue Xin, Dun Zhang, Yan Zeng, Peng Qi. (2023) An abiotic carbon dots@ ZIF-90 fluorescent probe for rapid and reliable detection of adenosine triphosphate. ANALYTICAL BIOCHEMISTRY, 663 (115021). [PMID:36539047]
7. Jinling Xu, Qi Lv, Shumin Pan, Huanhuan Qiu, Yu Liao, Ming Zhou, Weijie Li, Caiyan Li, Pan Zhang, Yujian Li, Guanglin Xu, Qingfeng Yu. (2022) M378 exhibits anti-inflammatory activities through NLRP3 signaling pathway. EUROPEAN JOURNAL OF PHARMACOLOGY, 933 (175261). [PMID:36100126]
8. Jiulong Zhang, Xiaoyan Sun, Lin Liu, Xiufeng Zhao, Chunrong Yang, Kexin Li, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao. (2022) Tumor-permeated ATP-based size-controllable immunogenic cell death amplifier remodel immunosuppressive microenvironment to boost cancer immunotherapy. Applied Materials Today, 28 (101518). [PMID:]
9. Jiulong Zhang, Xiaoyan Sun, Xiufeng Zhao, Chunrong Yang, Menghao Shi, Benzhuo Zhang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao. (2022) Combining immune checkpoint blockade with ATP-based immunogenic cell death amplifier for cancer chemo-immunotherapy. Acta Pharmaceutica Sinica B, 12 (3694). [PMID:36176905]
10. Jiulong Zhang, Xiaoyan Sun, Xiufeng Zhao, Lin Liu, Xin Cheng, Chunrong Yang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao. (2022) Watson–Crick Base Pairing-Inspired Laser/GSH Activatable miRNA-Coordination Polymer Nanoplexes for Combined Cancer Chemo-Immuno-Photothermal Therapy. ACS Applied Materials & Interfaces, 14 (18): (20762–20777). [PMID:35476413]

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Adenosine 5′-triphosphate disodium salt (ATP) - 10mM in Water, high purity , CAS No.987-65-5