Adiphenine HCl - ≥98%, high purity , CAS No.50-42-0

  • ≥98%
Item Number
A129364
Grouped product items
SKUSizeAvailabilityPrice Qty
A129364-1g
1g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$9.90
A129364-5g
5g
In stock
$23.90
A129364-10g
10g
In stock
$42.90
A129364-25g
25g
In stock
$83.90
A129364-50g
50g
In stock
$150.90
A129364-100g
100g
In stock
$270.90

Non-competitive Nicotinic acetylcholine receptor (nAChR) inhibitor. Used as an antispasmodic drug.

Basic Description

SynonymsNSC758234 | NSC-758234 | MLS002222150 | Prestwick_7 | 2-(Diethylamino)ethyl diphenylacetate hydrochloride | A828115 | ADIPHENINE HCL | Adiphenine hydrochloride (USAN) | 2-(diethylamino)ethyl 2,2-diphenylacetate;hydron;chloride | SCHEMBL33478 | Ethanol, 2-
Specifications & Purity≥98%
Biochemical and Physiological MechanismsAdiphenine HCl is a nicotinic receptor inhibitor.Non-competitive Nicotinic acetylcholine receptor (nAChR) inhibitor. Used as an antispasmodic drug.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Adiphenine HCl is a nicotinic receptor inhibitor with IC50 of 15 μM.

Associated Targets(Human)

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PMP22 Tbio Peripheral myelin protein 22 (699 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cavia porcellus (23802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chrm1 Muscarinic acetylcholine receptor (3770 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-(diethylamino)ethyl 2,2-diphenylacetate;hydrochloride
INCHI InChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14,19H,3-4,15-16H2,1-2H3;1H
InChi Key LKPINBXAWIMZCG-UHFFFAOYSA-N
Canonical SMILES CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Isomeric SMILES CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl
WGK Germany 3
RTECS AH2625000
Alternate CAS 64-95-9
PubChem CID 5763
Molecular Weight 347.88

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

9 results found

Lot NumberCertificate TypeDateItem
B2327156Certificate of AnalysisDec 06, 2024 A129364
B2327091Certificate of AnalysisDec 06, 2024 A129364
B2327148Certificate of AnalysisNov 12, 2022 A129364
B2327149Certificate of AnalysisNov 12, 2022 A129364
B2327152Certificate of AnalysisNov 12, 2022 A129364
B2327155Certificate of AnalysisNov 12, 2022 A129364
B2327165Certificate of AnalysisNov 12, 2022 A129364
E1504056Certificate of AnalysisNov 11, 2022 A129364
H2204199Certificate of AnalysisAug 06, 2022 A129364

Chemical and Physical Properties

SolubilityDMSO 30 mg/mL Water 70 mg/mL Ethanol 18 mg/mL
SensitivityMoisture sensitive
Melt Point(°C)117 °C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

WGK Germany 3
RTECS AH2625000
Merck Index 161

Related Documents

Citations of This Product

1. Jingyi Zhang, Zidan Cao, Di Fan, Yu Li, Tao Li, Baozeng Ren.  (2023)  Solid-liquid phase equilibrium of adiphenine hydrochloride in twelve pure solvents.  JOURNAL OF CHEMICAL THERMODYNAMICS,  183  (107067).  [PMID:] [10.1016/j.jct.2023.107067]

References

1. Jingyi Zhang, Zidan Cao, Di Fan, Yu Li, Tao Li, Baozeng Ren.  (2023)  Solid-liquid phase equilibrium of adiphenine hydrochloride in twelve pure solvents.  JOURNAL OF CHEMICAL THERMODYNAMICS,  183  (107067).  [PMID:] [10.1016/j.jct.2023.107067]

Solution Calculators