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Adomeglivant - 98%, high purity , CAS No.1488363-78-5, Antagonist of glucagon receptor
Glukagon Receptor Antagonists
Basic Description Synonyms F85410 | AKOS040741049 | FASLTMSUPQDLIB-MHZLTWQESA-N | A858152 | ADOMEGLIVANT [WHO-DD] | .BETA.-ALANINE, N-(4-((1S)-1-((4'-(1,1-DIMETHYLETHYL)-2,6-DIMETHYL(1,1'-BIPHENYL)-4-YL)OXY)-4,4,4-TRIFLUOROBUTYL)BENZOYL)- | MS-30128 | UNII-74Z5ZL2KVG | 1488363-78-5 Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms Adomeglivant (LY2409021) is a potent and selective antagonist of glukagon receptor that is used as a chronic treatment for type 2 diabetes. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of glucagon receptor Product Description Information
Adomeglivant Adomeglivant (LY2409021) is a potent and selective antagonist of glukagon receptor that is used as a chronic treatment for type 2 diabetes.
Adomeglivant (LY2409021) is a potent, selective glukagon receptor (GluR) allosteric antagonist. Adomeglivant is widely used in the research for type 2 diabetes mellitus.
Targets
Glukagon Receptor
Product Properties ALogP 7.839 HBD Count 1 Rotatable Bond 12
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers Pubchem Sid 488202541 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488202541 IUPAC Name 3-[[4-[(1S)-1-[4-(4-tert-butylphenyl)-3,5-dimethylphenoxy]-4,4,4-trifluorobutyl]benzoyl]amino]propanoic acid INCHI InChI=1S/C32H36F3NO4/c1-20-18-26(19-21(2)29(20)23-10-12-25(13-11-23)31(3,4)5)40-27(14-16-32(33,34)35)22-6-8-24(9-7-22)30(39)36-17-15-28(37)38/h6-13,18-19,27H,14-17H2,1-5H3,(H,36,39)(H,37,38)/t27-/m0/s1 InChi Key FASLTMSUPQDLIB-MHZLTWQESA-N Canonical SMILES CC1=CC(=CC(=C1C2=CC=C(C=C2)C(C)(C)C)C)OC(CCC(F)(F)F)C3=CC=C(C=C3)C(=O)NCCC(=O)O Isomeric SMILES CC1=CC(=CC(=C1C2=CC=C(C=C2)C(C)(C)C)C)O[C@@H](CCC(F)(F)F)C3=CC=C(C=C3)C(=O)NCCC(=O)O Alternate CAS 872260-20-3,1488363-78-5 PubChem CID 91933867 MeSH Entry Terms (+)-adomeglivant;(+-)-adomeglivant;(-)-adomeglivant;3-(4-((1R)-1-((4'-tert-butyl-2,6-dimethylbiphenyl-4-yl)oxy)-4,4,4-trifluorobutyl)benzamido)propanoic acid;3-(4-((1S)-1-((4'-tert-butyl-2,6-dimethylbiphenyl-4-yl)oxy)-4,4,4-trifluorobutyl)benzamido)propan Molecular Weight 555.63
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 100 mg/mL (179.97 mM); Ethanol: 100 mg/mL (179.97 mM); Water: Insoluble; DMSO(mg / mL) Max Solubility 100 DMSO(mM) Max Solubility 179.975883231647 Water(mg / mL) Max Solubility ＜1
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C2321105