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adriforant , Histamine H4 receptor antagonist, CAS No.A607425, Histamine H4 receptor antagonist

PubChem CID: 24745335

Item Number

A607425

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SKU	Size	Availability	Price	Qty
A607425-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607425-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,900.90

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H3 receptor Antagonist H4 receptor Antagonist

Basic Description

Synonyms	Adriforant \| PF-3893787 \| ZPL-389 \| ZPL-3893787 \| Adriforant [USAN] \| NVP-ZPL389-NX \| ZPL389-NX \| 943057-12-3 \| D65H9YE9VU \| PF-03893787 \| UNII-D65H9YE9VU \| ZPL-389-NX \| CHEMBL1915540 \| WHO 10855 \| (R)-N4-(cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine \| 2
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Histamine H4 receptor antagonist

Associated Targets(Human)

HRH4 Tchem Histamine H4 receptor (12 Activities)

Discover Target: HRH4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH3 Tclin Histamine H3 receptor (1 Activities)

Discover Target: HRH3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (1 Activities)

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HRH2 Tclin Histamine H2 receptor (5428 Activities)

Discover Target: HRH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH1 Tclin Histamine H1 receptor (7573 Activities)

Discover Target: HRH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH3 Tclin Histamine H3 receptor (10389 Activities)

Discover Target: HRH3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsomes (16955 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hrh4 Histamine H4 receptor (388 Activities)

Discover Target: Hrh4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Canis familiaris (36305 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasma (328 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N'-(cyclopropylmethyl)-6-[(3R)-3-methylaminopyrrolidin-1-yl]pyrimidine-2,4-diamine
INCHI	InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
InChi Key	ISBHYKVAFKTATD-SNVBAGLBSA-N
Canonical SMILES	CN[C@@H]1CCN(C1)c1cc(NCC2CC2)nc(n1)N
Isomeric SMILES	CN[C@@H]1CCN(C1)C2=NC(=NC(=C2)NCC3CC3)N
PubChem CID	24745335

PubChem CID

24745335

ChEMBL Ligand

CHEMBL1915540

GPCRdb Ligand

adriforant

References

1. Ehling S, Roßbach K, Dunston SM, Stark H, Bäumer W. (2016) Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo.. J Dermatol Sci, 83 (2): (106-15). [PMID:27155791]
2. Werfel T, Layton G, Yeadon M, Whitlock L, Osterloh I, Jimenez P, Liu W, Lynch V, Asher A, Tsianakas A et al.. (2019) Efficacy and safety of the histamine H₄ receptor antagonist ZPL-3893787 in patients with atopic dermatitis.. J Allergy Clin Immunol, 143 (5): (1830-1837.e4). [PMID:30414855]

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adriforant , Histamine H4 receptor antagonist, CAS No.A607425, Histamine H4 receptor antagonist

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

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