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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A412269-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $20.90 | |
A412269-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $79.90 | |
A412269-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $119.90 | |
A412269-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $379.90 | |
A412269-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $239.90 | |
A412269-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $599.90 |
Specifications & Purity | Moligand™, ≥98% |
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Biochemical and Physiological Mechanisms | ADX88178 is a potent positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 4 receptor |
Product Description | Information ADX88178 is a potent positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine |
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INCHI | InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18) |
InChi Key | MIQNXKWDQRNHAU-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3 |
Isomeric SMILES | CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3 |
PubChem CID | 46836872 |
Molecular Weight | 272.33 |
PubChem CID | 46836872 |
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CAS Registry No. | 1235318-89-4 |
GPCRdb Ligand | ADX88178 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2419135 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419136 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419137 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419138 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419139 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419140 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419141 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419142 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419143 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419144 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419145 | Certificate of Analysis | Feb 04, 2024 | A412269 |
D2419146 | Certificate of Analysis | Feb 04, 2024 | A412269 |