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ADX-88178 - 98%, high purity , CAS No.1235318-89-4, Allosteric modulator of mGlu 4 receptor

  • Moligand™
  • ≥98%
Item Number
A412269
Grouped product items
SKUSizeAvailabilityPrice Qty
A412269-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$20.90
A412269-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$79.90
A412269-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$119.90
A412269-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$379.90
A412269-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$239.90
A412269-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$599.90

Basic Description

Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsADX88178 is a potent positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of mGlu 4 receptor
Product Description

Information

ADX88178 is a potent positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.

Associated Targets

GRM4 Tchem Metabotropic glutamate receptor 4 5 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM7 Tchem Metabotropic glutamate receptor 7 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GRM8 Tchem Metabotropic glutamate receptor 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 5-methyl-N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-1,3-thiazol-2-amine
INCHI InChI=1S/C12H12N6S/c1-7-3-4-13-11(16-7)18-12-17-10(8(2)19-12)9-5-14-15-6-9/h3-6H,1-2H3,(H,14,15)(H,13,16,17,18)
InChi Key MIQNXKWDQRNHAU-UHFFFAOYSA-N
Canonical SMILES CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3
Isomeric SMILES CC1=NC(=NC=C1)NC2=NC(=C(S2)C)C3=CNN=C3
PubChem CID 46836872
Molecular Weight 272.33

Certificates

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12 results found

Lot NumberCertificate TypeDateItem
D2419135Certificate of AnalysisFeb 04, 2024 A412269
D2419136Certificate of AnalysisFeb 04, 2024 A412269
D2419137Certificate of AnalysisFeb 04, 2024 A412269
D2419138Certificate of AnalysisFeb 04, 2024 A412269
D2419139Certificate of AnalysisFeb 04, 2024 A412269
D2419140Certificate of AnalysisFeb 04, 2024 A412269
D2419141Certificate of AnalysisFeb 04, 2024 A412269
D2419142Certificate of AnalysisFeb 04, 2024 A412269
D2419143Certificate of AnalysisFeb 04, 2024 A412269
D2419144Certificate of AnalysisFeb 04, 2024 A412269
D2419145Certificate of AnalysisFeb 04, 2024 A412269
D2419146Certificate of AnalysisFeb 04, 2024 A412269

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