AEBSF Solution - 50mg/ml in H2O, high purity , CAS No.30827-99-7

  • 50mg/ml in H2O
Item Number
A301905
Grouped product items
SKUSizeAvailabilityPrice Qty
A301905-0.5ml
0.5ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$255.90

Basic Description

Synonyms30827-99-7 | 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride | AEBSF HCl | AEBSF | AEBSF hydrochloride | Pefabloc SC | Pefabloc | 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride | AEBSF (hydrochloride) | 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochlor
Specifications & Purity50mg/ml in H2O
Biochemical and Physiological MechanismsIrreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, impr
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

CTSG Tchem Cathepsin G 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TMPRSS4 Tbio Transmembrane protease serine 4 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PLG Tclin Plasminogen 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CELA1 Tchem Chymotrypsin-like elastase family member 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

F2 Tclin Prothrombin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Thrombin 11687 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Plasminogen 2339 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

HERG 29587 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Cathepsin G 2304 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

DNA polymerase kappa 8653 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

DNA polymerase iota 116820 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Geminin 128009 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Solute carrier organic anion transporter family member 1B1 2672 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

ATPase family AAA domain-containing protein 5 122566 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Solute carrier organic anion transporter family member 1B3 2517 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Transmembrane protease serine 4 563 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Beta-lactamase AmpC 62480 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Plasmodium falciparum 966862 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Nuclear factor erythroid 2-related factor 2 214 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Pancreatic elastase 395 Activities

Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
INCHI InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key WRDABNWSWOHGMS-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Isomeric SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
WGK Germany 3
PubChem CID 186136
UN Number 3261
Molecular Weight 239.69
Beilstein 7604627
Reaxy-Rn 7604627

Certificates

Certificate of Analysis(COA)

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1 results found

Lot NumberCertificate TypeDateItem
F2110977Certificate of AnalysisMay 12, 2023 A301905

Chemical and Physical Properties

SolubilitySoluble in water 50 mg/mL or 100% ethanol.
SensitivityMoisture Sensitive
Melt Point(°C)181-185°C

Safety and Hazards(GHS)

Pictogram(s) GHS05
Signal Danger
Hazard Statements

H314:Causes severe skin burns and eye damage

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P310:Immediately call a POISON CENTER or doctor/physician.

WGK Germany 3
Reaxy-Rn 7604627

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Citations of This Product

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua.  (2023)  A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.  MOLECULES,  28  (5): (2317).  [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang.  (2022)  Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.  ANALYTICAL CHEMISTRY,  94  (50): (17692–17699).  [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang.  (2022)  Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems.  DYES AND PIGMENTS,  198  (109993).  [PMID:]

References

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua.  (2023)  A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.  MOLECULES,  28  (5): (2317).  [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang.  (2022)  Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.  ANALYTICAL CHEMISTRY,  94  (50): (17692–17699).  [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang.  (2022)  Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems.  DYES AND PIGMENTS,  198  (109993).  [PMID:]

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