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A301905-0.5ml

0.5ml

Available within 4-8 weeks(?)

$255.90

Basic Description

Synonyms	Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride \| DHA6VL95HL \| 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride [for biochemical research] \| EX-A2487 \| T70748 \| AKOS015847774 \| Pefabloc(R) SC, certified reference material, TraceCERT(R) \|
Specifications & Purity	50mg/ml in H2O
Biochemical and Physiological Mechanisms	Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, impr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLG Tclin Plasminogen (2339 Activities)

Discover Target: PLG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSG Tchem Cathepsin G (2304 Activities)

Discover Target: CTSG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLK Tbio DNA polymerase kappa (8653 Activities)

Discover Target: POLK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)

Discover Target: SLCO1B1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)

Discover Target: SLCO1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CELA2A Pancreatic elastase (395 Activities)

Discover Target: CELA2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
INCHI	InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key	WRDABNWSWOHGMS-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Isomeric SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
WGK Germany	3
PubChem CID	186136
UN Number	3261
Molecular Weight	239.69
Beilstein	7604627
Reaxy-Rn	7604627

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot Number	Certificate Type	Date	Item
F2110977	Certificate of Analysis	May 12, 2023	A301905

Chemical and Physical Properties

Solubility	Soluble in water 50 mg/mL or 100% ethanol.
Sensitivity	Moisture Sensitive
Melt Point(°C)	181-185°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician.
WGK Germany	3
Reaxy-Rn	7604627

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua. (2023) A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging. MOLECULES, 28 (5): (2317). [PMID:36903562] [10.3390/molecules28052317]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707] [10.1021/acs.analchem.2c04614]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [PMID:] [10.1016/j.dyepig.2021.109993]
4. Yu Zhu Yang, Zi Yi Xu, Nian Bing Li, Hong Qun Luo. (2021) Ultrasensitive fluorescent probe for visual biosensing of esterase activity in living cells and its imaging application. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120094). [PMID:34175764] [10.1016/j.saa.2021.120094]
5. Shuli Man, Miao Li, Jin Zhou, Haiyue Wang, Jinyan Zhang, Long Ma. (2019) Polyethyleneimine coated Fe3O4 magnetic nanoparticles induce autophagy, NF-κB and TGF-β signaling pathway activation in HeLa cervical carcinoma cells via reactive oxygen species generation. Biomaterials Science, 8 (1): (201-211). [PMID:31664285] [10.1039/C9BM01563A]
6. Hui Zhou, Jinbao Tang, Jie Zhang, Bochao Chen, Jianfei Kan, Weifen Zhang, Jin Zhou, Huimin Ma. (2019) A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging. Journal of Materials Chemistry B, 7 (18): (2989-2996). [PMID:] [10.1039/C9TB00310J]
7. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979]

References

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua. (2023) A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging. MOLECULES, 28 (5): (2317). [PMID:36903562] [10.3390/molecules28052317]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707] [10.1021/acs.analchem.2c04614]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [PMID:] [10.1016/j.dyepig.2021.109993]
4. Yu Zhu Yang, Zi Yi Xu, Nian Bing Li, Hong Qun Luo. (2021) Ultrasensitive fluorescent probe for visual biosensing of esterase activity in living cells and its imaging application. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 262 (120094). [PMID:34175764] [10.1016/j.saa.2021.120094]
5. Shuli Man, Miao Li, Jin Zhou, Haiyue Wang, Jinyan Zhang, Long Ma. (2019) Polyethyleneimine coated Fe3O4 magnetic nanoparticles induce autophagy, NF-κB and TGF-β signaling pathway activation in HeLa cervical carcinoma cells via reactive oxygen species generation. Biomaterials Science, 8 (1): (201-211). [PMID:31664285] [10.1039/C9BM01563A]
6. Hui Zhou, Jinbao Tang, Jie Zhang, Bochao Chen, Jianfei Kan, Weifen Zhang, Jin Zhou, Huimin Ma. (2019) A red lysosome-targeted fluorescent probe for carboxylesterase detection and bioimaging. Journal of Materials Chemistry B, 7 (18): (2989-2996). [PMID:] [10.1039/C9TB00310J]
7. Juan Wang, Mengmeng Song, Chengguo Hu, Kangbing Wu. (2018) Portable, Self-Powered, and Light-Addressable Photoelectrochemical Sensing Platforms Using pH Meter Readouts for High-Throughput Screening of Thrombin Inhibitor Drugs. ANALYTICAL CHEMISTRY, 90 (15): (9366–9373). [PMID:29998727] [10.1021/acs.analchem.8b01979]

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AEBSF Solution - 50mg/ml in H2O, high purity , CAS No.30827-99-7