Grouped product items

SKU

Size

Availability

Price

Qty

A301913-0.5ml

0.5ml

Available within 4-8 weeks(?)

$117.90

A301913-2×0.5ml

2×0.5ml

Available within 8-12 weeks(?)

$212.90

Basic Description

Synonyms	30827-99-7 \| 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride \| AEBSF HCl \| AEBSF \| AEBSF hydrochloride \| Pefabloc SC \| Pefabloc \| 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride \| AEBSF (hydrochloride) \| 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochlor
Specifications & Purity	10mg/ml in H2O
Biochemical and Physiological Mechanisms	Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, impr
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

CTSG Tchem Cathepsin G 0 Activities

Discover Target: CTSG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

Discover Target: SLCO1B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

Discover Target: SLCO1B3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TMPRSS4 Tbio Transmembrane protease serine 4 0 Activities

Discover Target: TMPRSS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Discover Target: POLK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLG Tclin Plasminogen 0 Activities

Discover Target: PLG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CELA1 Tchem Chymotrypsin-like elastase family member 1 0 Activities

Discover Target: CELA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2 Tclin Prothrombin 0 Activities

Discover Target: F2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ATAD5 Tbio ATPase family AAA domain-containing protein 5 0 Activities

Discover Target: ATAD5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Thrombin 11687 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasminogen 2339 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HERG 29587 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cathepsin G 2304 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DNA polymerase kappa 8653 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DNA polymerase iota 116820 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Geminin 128009 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Solute carrier organic anion transporter family member 1B1 2672 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATPase family AAA domain-containing protein 5 122566 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Solute carrier organic anion transporter family member 1B3 2517 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Transmembrane protease serine 4 563 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Beta-lactamase AmpC 62480 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum 966862 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nuclear factor erythroid 2-related factor 2 214 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Pancreatic elastase 395 Activities

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
INCHI	InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key	WRDABNWSWOHGMS-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Isomeric SMILES	C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
WGK Germany	3
PubChem CID	186136
UN Number	3261
Molecular Weight	239.69
Beilstein	7604627
Reaxy-Rn	7604627

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

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1 results found

Lot Number	Certificate Type	Date	Item
F2110978	Certificate of Analysis	May 12, 2023	A301913

Chemical and Physical Properties

Solubility	Soluble in water 50 mg/mL or 100% ethanol.
Sensitivity	Moisture Sensitive
Melt Point(°C)	181-185°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P310:Immediately call a POISON CENTER or doctor/physician.
WGK Germany	3
Reaxy-Rn	7604627

Alternative Products

Citations of This Product

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua. (2023) A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging. MOLECULES, 28 (5): (2317). [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [PMID:]

References

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua. (2023) A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging. MOLECULES, 28 (5): (2317). [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang. (2022) Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. ANALYTICAL CHEMISTRY, 94 (50): (17692–17699). [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang. (2022) Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems. DYES AND PIGMENTS, 198 (109993). [PMID:]

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SKU	Size	Availability	Price	Qty
A301913-0.5ml	0.5ml	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$117.90
A301913-2×0.5ml	2×0.5ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$212.90

AEBSF Solution - 10mg/ml in H2O, high purity , CAS No.30827-99-7