AEE788 (NVP-AEE788) - ≥97%, high purity , Vascular endothelial growth factor receptor 1 inhibitor, CAS No.497839-62-0, Vascular endothelial growth factor receptor 1 inhibitor

Item Number

A126830

• Synonyms: 497839-62-0 | AEE788 | AEE-788 | AEE 788 | NVP-AEE788 | (R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | AEE788 (NVP-AEE788) | GNF-Pf-5343 | NVP-AEE 788 | NVP-AEE-788 | F9JLR95I3I | 6-{4-[(4-Ethylpiperazin-1-Yl)methyl]pheny
• Specifications & Purity: ≥97%
• Biochemical and Physiological Mechanisms: Potent EGFR and VEGFR inhibitor (IC50values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC50values are 52, 60 and 61 nM respectively). Inhibits proliferation of
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Action Type: INHIBITOR
• Mechanism of action: Vascular endothelial growth factor receptor 1 inhibitor
• Note: 卖完停产，不再备货

Product Description

AEE788 (NVP-AEE788) is a potent inhibitor of EGFR and HER2/ErbB2 with IC50 of 2 nM and 6 nM, less potent to VEGFR2/KDR, c-Abl, c-Src, and Flt-1, does not inhibit Ins-R, IGF-1R, PKCα and CDK1.