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Aerosol OT - 96%, high purity , CAS No.577-11-7

≥96%

CAS#: 577-11-7
Formula: C₂₀H₃₇NaO₇S
Molecular Weight: 444.56
Beilstein Registry Number: 4117588
EC Number: 209-406-4
MDL number: MFCD00012455
PubChem CID: 23673837

Item Number

A106730

Grouped product items
SKU	Size	Availability	Price
A106730-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$21.90
A106730-100g	100g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$33.90
A106730-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$60.90

View related series

Anionic surfactant Polymer / polymer reagent Polymer additives Sulfonates

Basic Description

Synonyms	Docusate sodium\|577-11-7\|Dioctyl sodium sulfosuccinate\|Aerosol OT\|Dioctyl sulfosuccinate sodium salt\|Dioctylal\|Diotilan\|Disonate\|Molatoc\|Regutol\|Velmol\|Doxol\|Nevax\|Constonate\|Dialose\|Doxinate\|Soliwax\|Molcer\|Waxsol\|Adekacol EC 8600\|Docusate (Sodium)\|Mervam
Specifications & Purity	≥96%
Storage Temp	Argon charged
Shipped In	Normal
Note	15kg卖完停产，不再备货
Product Description	Docusate sodium salt has been used in a study to assess chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticals.It has also been used in a study to investigate different formulations for drug delivery through the nail plate.

Associated Targets

VDR Tclin Vitamin D3 receptor 0 Activities

Discover Target: VDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RXRA Tclin Retinoic acid receptor RXR-alpha 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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PPARA Tclin Peroxisome proliferator-activated receptor alpha 0 Activities

Discover Target: PPARA

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PPARG Tclin Peroxisome proliferator-activated receptor gamma 0 Activities

Discover Target: PPARG

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NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Discover Target: NFE2L2

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Names and Identifiers

IUPAC Name	sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
INCHI	InChI=1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1
InChi Key	APSBXTVYXVQYAB-UHFFFAOYSA-M
Canonical SMILES	CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)[O-].[Na+]
Isomeric SMILES	CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)[O-].[Na+]
WGK Germany	3
RTECS	WN0525000
PubChem CID	23673837
Molecular Weight	444.56
Beilstein	4117588
Reaxy-Rn	4117588

Certificates

Certificate of Analysis(COA)

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22 results found

Lot Number	Certificate Type	Date	Item
G2424263	Certificate of Analysis	Jul 01, 2024	A106730
G2424159	Certificate of Analysis	Jul 01, 2024	A106730
G2424158	Certificate of Analysis	Jul 01, 2024	A106730
G2424157	Certificate of Analysis	Jul 01, 2024	A106730
G2424156	Certificate of Analysis	Jul 01, 2024	A106730
G2404131	Certificate of Analysis	Jun 17, 2024	A106730
C2421106	Certificate of Analysis	Mar 05, 2024	A106730
C2421104	Certificate of Analysis	Mar 05, 2024	A106730
C2421105	Certificate of Analysis	Mar 05, 2024	A106730
C2414085	Certificate of Analysis	Mar 05, 2024	A106730
C2401098	Certificate of Analysis	Jan 18, 2024	A106730
C2401099	Certificate of Analysis	Jan 18, 2024	A106730
L2214645	Certificate of Analysis	Jan 17, 2023	A106730
G2329059	Certificate of Analysis	Dec 30, 2022	A106730
G2329063	Certificate of Analysis	Dec 30, 2022	A106730
G2329054	Certificate of Analysis	Dec 30, 2022	A106730
I1825017	Certificate of Analysis	Jul 20, 2022	A106730
B2207068	Certificate of Analysis	Dec 28, 2021	A106730
B2207130	Certificate of Analysis	Dec 28, 2021	A106730
B2207118	Certificate of Analysis	Dec 28, 2021	A106730
B2207117	Certificate of Analysis	Dec 28, 2021	A106730
H2309514	Certificate of Analysis	Sep 07, 2021	A106730

Chemical and Physical Properties

Solubility	Soluble in water and methanol.
Sensitivity	Hygroscopic
Melt Point(°C)	153-157°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help.
WGK Germany	3
RTECS	WN0525000
Reaxy-Rn	4117588
Merck Index	3401

Alternative Products

References

1. Giovanna Longhi,Sergio Abbate,Leopoldo Ceraulo,Alberto Ceselli,Sandro L Fornili,Vincenzo Turco Liveri. (2011-11-04) A molecular dynamics study of structure, stability and fragmentation patterns of sodium bis(2-ethylhexyl)sulfosuccinate positively charged aggregates in vacuo.. Physical chemistry chemical physics : PCCP, 13 ((48)): (21423-21431). [PMID:22048331]
2. O Fernando Silva,Mariana A Fernández,Juana J Silber,Rita H de Rossi,N Mariano Correa. (2011-11-19) Inhibited phenol ionization in reverse micelles: confinement effect at the nanometer scale.. Chemphyschem : a European journal of chemical physics and physical chemistry, 13 ((1)): (124-130). [PMID:22095797]
3. Marc-Elie Nader,Issam Saliba. (2011-11-22) Ototoxicity of intratympanic docusate sodium and mineral oil in the guinea pig.. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 146 ((3)): (455-460). [PMID:22101097]
4. Gabriela V Porcal,Carlos A Chesta,M Alicia Biasutti,Sonia G Bertolotti,Carlos M Previtali. (2011-11-23) Quenching of the triplet state of Safranine-O by aliphatic amines in AOT reverse micelles studied by transient absorption spectroscopy.. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 11 ((2)): (302-308). [PMID:22105094]
5. Masaharu Ueno. (2011-12-02) [World constructed by self-organization of some amphiphils--with a focus on vesicle formation--].. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 131 ((12)): (1765-1779). [PMID:22129875]
6. Silvina S Quintana,R Dario Falcone,Juana J Silber,N Mariano Correa. (2011-12-03) Comparison between two anionic reverse micelle interfaces: the role of water-surfactant interactions in interfacial properties.. Chemphyschem : a European journal of chemical physics and physical chemistry, 13 ((1)): (115-123). [PMID:22135080]
7. Kellie A Woll,Elie J Schuchardt,Claire R Willis,Christopher D Ortengren,Noah Hendricks,Mitch Johnson,Ernestas Gaidamauskas,Bharat Baruah,Audra G Sostarecz,Deanna R Worley,David W Osborne,Debbie C Crans. (2011-12-14) Gel formulation containing mixed surfactant and lipids associating with carboplatin.. Chemistry & biodiversity, 8 ((12)): (2195-2210). [PMID:22162158]
8. Xi Yu,Jintao Zhu. (2011-12-27) A facile way to fabricate polyester microcapsules.. Journal of controlled release : official journal of the Controlled Release Society, 152 Suppl 1 (e128-e129). [PMID:22195798]
9. Zhengjin Jiang,John Reilly. (2011-12-28) Chromatography approaches for early screening of the phospholipidosis-inducing potential of pharmaceuticals.. Journal of pharmaceutical and biomedical analysis, 61 (184-190). [PMID:22200505]
10. Shu Ian Cheng,David C Stuckey. (2012-01-12) Protein recovery from surfactant precipitation.. Biotechnology progress, 27 ((6)): (1614-1622). [PMID:22235487]
11. Johnson Mathew,David L Schroeder,Lawrence B Zintek,Caitlin R Schupp,Michael G Kosempa,Adam M Zachary,George C Schupp,Dennis J Wesolowski. (2012-03-01) Dioctyl sulfosuccinate analysis in near-shore Gulf of Mexico water by direct-injection liquid chromatography-tandem mass spectrometry.. Journal of chromatography. A, 1231 (46-51). [PMID:22365569]
12. Sonali V Kapse,Rajiv V Gaikwad,Abdul Samad,Padma V Devarajan. (2012-03-15) Self nanoprecipitating preconcentrate of tamoxifen citrate for enhanced bioavailability.. International journal of pharmaceutics, 429 ((1-2)): (104-112). [PMID:22414426]
13. Anna McNanley,Mare Perevich,Chris Glantz,Erin E Duecy,Michael K Flynn,Gunhilde Buchsbaum. (2012-03-29) Bowel function after minimally invasive urogynecologic surgery: a prospective randomized controlled trial.. Female pelvic medicine & reconstructive surgery, 18 ((2)): (82-85). [PMID:22453316]
14. Jerry Nesamony,Carrie L Zachar,Rose Jung,Frederick E Williams,Surya Nauli. (2012-04-07) Preparation, characterization, sterility validation, and in vitro cell toxicity studies of microemulsions possessing potential parenteral applications.. Drug development and industrial pharmacy, 39 ((2)): (240-251). [PMID:22480266]
15. Myles Sedgwick,Richard L Cole,Christopher D Rithner,Debbie C Crans,Nancy E Levinger. (2012-07-07) Correlating proton transfer dynamics to probe location in confined environments.. Journal of the American Chemical Society, 134 ((29)): (11904-11907). [PMID:22765228]
16. Reiko Yutani,Shin-ya Morita,Reiko Teraoka,Shuji Kitagawa. (2012-08-07) Distribution of polyphenols and a surfactant component in skin during Aerosol OT microemulsion-enhanced intradermal delivery.. Chemical & pharmaceutical bulletin, 60 ((8)): (989-994). [PMID:22863702]
17. Chengfei Lu,Susmita Das,Paul K S Magut,Min Li,Bilal El-Zahab,Isiah M Warner. (2012-09-11) Irradiation induced fluorescence enhancement in PEGylated cyanine-based NIR nano- and mesoscale GUMBOS.. Langmuir : the ACS journal of surfaces and colloids, 28 ((40)): (14415-14423). [PMID:22957476]
18. Maria D Donoso,Roy J Haskell,Richard R Schartman. (2012-09-18) Surfactant choice and the physical stability of nanosuspensions as a function of pH.. International journal of pharmaceutics, 439 ((1-2)): (1-7). [PMID:22982488]
19. Ashima Malik,Jayanta Kundu,Sanjib K Mukherjee,Pramit K Chowdhury. (2012-10-03) Myoglobin unfolding in crowding and confinement.. The journal of physical chemistry. B, 116 ((43)): (12895-12904). [PMID:23025527]
20. D Das,J Dey,A K Chandra,U Thapa,K Ismail. (2012-10-18) Aggregation behavior of sodium dioctylsulfosuccinate in aqueous ethylene glycol medium. A case of hydrogen bonding between surfactant and solvent and its manifestation in the surface tension isotherm.. Langmuir : the ACS journal of surfaces and colloids, 28 ((45)): (15762-15769). [PMID:23072621]
21. Maya George,Indrajit Ghosh. (2012-10-23) Identifying the correlation between drug/stabilizer properties and critical quality attributes (CQAs) of nanosuspension formulation prepared by wet media milling technology.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48 ((1-2)): (142-152). [PMID:23085547]
22. Tamás Bánsági,Vladimir K Vanag,Irving R Epstein. (2012-12-12) Two- and three-dimensional standing waves in a reaction-diffusion system.. Physical review. E, Statistical, nonlinear, and soft matter physics, 86 ((4 Pt 2)): (045202-045202). [PMID:23214640]
23. Dipanwita De,Manas Sajjan,Janaky Narayanan,Jayesh R Bellare,Anindya Datta. (2012-12-18) Nanoconfinement of water layers in lamellar structures prepared in the presence and absence of organic solvent.. The journal of physical chemistry. B, 117 ((7)): (2106-2112). [PMID:23240713]
24. Yigang Fang,Fangwei Liu,Jianbo Liu. (2012-12-19) Mass spectrometry study of multiply negatively charged, gas-phase NaAOT micelles: how does charge state affect micellar structure and encapsulation?. Journal of the American Society for Mass Spectrometry, 24 ((1)): (9-20). [PMID:23247969]
25. Gregory N Smith,Paul Brown,Sarah E Rogers,Julian Eastoe. (2013-02-16) Evidence for a critical micelle concentration of surfactants in hydrocarbon solvents.. Langmuir : the ACS journal of surfaces and colloids, 29 ((10)): (3252-3258). [PMID:23410112]
26. U Thapa,K Ismail. (2013-07-06) Urea effect on aggregation and adsorption of sodium dioctylsulfosuccinate in water.. Journal of colloid and interface science, 406 (172-177). [PMID:23827480]
27. Tiberio M Frisoli,Daniel G Swistel,Harikrishna Makani,Mark V Sherrid. (2013-08-24) Wretched excess: stool-softener abuse and cardiogenic shock.. The American journal of medicine, 126 ((9)): (773-775). [PMID:23968901]
28. Mohammad A Azad,Catharina Knieke,Daniel To,Rajesh Davé. (2013-10-10) Preparation of concentrated stable fenofibrate suspensions via liquid antisolvent precipitation.. Drug development and industrial pharmacy, 40 ((12)): (1693-1703). [PMID:24102617]
29. Teresa Ruston,Kathleen Hunter,Greta Cummings,Adriana Lazarescu. (2014-01-17) Efficacy and side-effect profiles of lactulose, docusate sodium, and sennosides compared to PEG in opioid-induced constipation: a systematic review.. Canadian oncology nursing journal = Revue canadienne de nursing oncologique, 23 ((4)): (236-246). [PMID:24428006]
30. Anju Gupta,Maximilian Sender,Sarah Fields,Geoffrey D Bothun. (2014-08-31) Phase and sedimentation behavior of oil (octane) dispersions in the presence of model mineral aggregates.. Marine pollution bulletin, 87 ((1-2)): (164-170). [PMID:25172613]
31. Pierre Paré,Richard N Fedorak. (2014-11-13) Systematic review of stimulant and nonstimulant laxatives for the treatment of functional constipation.. Canadian journal of gastroenterology & hepatology, 28 ((10)): (549-557). [PMID:25390617]
32. Wei Gao,Baoyong Sha,Yongchun Liu,Daocheng Wu,Xin Shen,Guixia Jing. (2015-03-10) The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin.. Artificial cells, nanomedicine, and biotechnology, 43 ((3)): (196-202). [PMID:25749279]
33. G A ter Boo,D W Grijpma,R G Richards,T F Moriarty,D Eglin. (2015-03-31) Preparation of gentamicin dioctyl sulfosuccinate loaded poly(trimethylene carbonate) matrices intended for the treatment of orthopaedic infections.. Clinical hemorheology and microcirculation, 60 ((1)): (89-98). [PMID:25818154]
34. Sharad B Murdande,Dhaval A Shah,Rutesh H Dave. (2015-03-31) Impact of nanosizing on solubility and dissolution rate of poorly soluble pharmaceuticals.. Journal of pharmaceutical sciences, 104 ((6)): (2094-2102). [PMID:25821105]
35. Avijit Paul,Hee Ju,Sabarinathan Rangasamy,Yumi Shim,Joon Myong Song. (2015-04-09) Nanosized silver (II) pyridoxine complex to cause greater inflammatory response and less cytotoxicity to RAW264.7 macrophage cells.. Nanoscale research letters, 10 (140-140). [PMID:25852430]
36. Ericka Rodríguez-León,Ramón Íñiguez-Palomares,Efraín Urrutia-Bañuelos,Ronaldo Herrera-Urbina,Judith Tánori,Amir Maldonado. (2015-04-18) Self-alignment of silver nanoparticles in highly ordered 2D arrays.. Nanoscale research letters, 10 (101-101). [PMID:25883540]
37. Catalina Sandoval,Anakenna Ortega,Susana A Sanchez,Javier Morales,German Gunther. (2015-04-24) Structuration in the interface of direct and reversed micelles of sucrose esters, studied by fluorescent techniques.. PloS one, 10 ((4)): (e0123669-e0123669). [PMID:25905632]
38. Olga D Bekasova,Alexandra A Revina,Ekaterina S Kornienko,Boris I Kurganov. (2015-05-04) The Photovoltaic Effect of CdS Quantum Dots Synthesized in Inverse Micelles and R-Phycoerythrin Tunnel Cavities.. Applied biochemistry and biotechnology, 176 ((4)): (1141-1150). [PMID:25935221]
39. Grzegorz Kiełbowicz,Anna Chojnacka,Anna Gliszczyńska,Witold Gładkowski,Marek Kłobucki,Natalia Niezgoda,Czesław Wawrzeńczyk. (2015-05-13) Positional analysis of phosphatidylcholine and phosphatidylethanolamine via LC with a charged aerosol detector.. Talanta, 141 (137-142). [PMID:25966393]
40. Y H Kim,H B Lim. (2015-06-20) Laser-induced fluorescence reader with a turbidimetric system for sandwich-type immunoassay using nanoparticles.. Analytica chimica acta, 883 (32-36). [PMID:26088773]
41. Komal Sethi,Indrajit Roy. (2015-06-21) Organically modified titania nanoparticles for sustained drug release applications.. Journal of colloid and interface science, 456 (59-65). [PMID:26093234]
42. L D McDaniel,J Basso,E Pulster,J H Paul. (2015-06-25) Sand patties provide evidence for the presence of Deepwater Horizon oil on the beaches of the West Florida Shelf.. Marine pollution bulletin, 97 ((1-2)): (67-77). [PMID:26104828]
43. Mukesh K Sharma,J Narayanan,Sanjay Upadhyay,Ajay K Goel. (2015-07-08) Electrochemical immunosensor based on bismuth nanocomposite film and cadmium ions functionalized titanium phosphates for the detection of anthrax protective antigen toxin.. Biosensors & bioelectronics, 74 (299-304). [PMID:26148674]
44. S M Kelleher,R I Nooney,S P Flynn,E Clancy,M Burke,S Daly,T J Smith,S Daniels,C McDonagh. (2015-08-22) Multivalent linkers for improved covalent binding of oligonucleotides to dye-doped silica nanoparticles.. Nanotechnology, 26 ((36)): (365703-365703). [PMID:26294441]
45. Sławomir Oszwałdowski,Pavel Kubáň. (2015-08-25) Capillary electrophoresis study on segment/segment system for segments based on phase of mixed micelles and its role in transport of particles between the two segments.. Journal of chromatography. A, 1412 (139-150). [PMID:26296987]
46. Mariana Bulgarella,George E Heimpel. (2015-09-19) Host range and community structure of avian nest parasites in the genus Philornis (Diptera: Muscidae) on the island of Trinidad.. Ecology and evolution, 5 ((17)): (3695-3703). [PMID:26380698]
47. Rongfeng Yuan,Chang Yan,Amr Tamimi,Michael D Fayer. (2015-10-06) Molecular Anion Hydrogen Bonding Dynamics in Aqueous Solution.. The journal of physical chemistry. B, 119 ((42)): (13407-13415). [PMID:26434772]
48. Nikolay O Mchedlov-Petrossyan,Tatiana A Cheipesh,Alexander D Roshal,Andrey O Doroshenko,Natalya A Vodolazkaya. (2017-03-30) Fluorescence of aminofluoresceins as an indicative process allowing one to distinguish between micelles of cationic surfactants and micelle-like aggregates.. Methods and applications in fluorescence, 4 ((3)): (034002-034002). [PMID:28355149]
49. Mehdi Hoseini,Soheil Sharifi,Ameneh Sazgarnia. (2020-04-28) The Influence of Anionic, Cationic Surfactant and AOT/Water/Heptane Reverse Micelle on Photophysical Properties of Crocin: Compare with RPMI Effect.. Journal of fluorescence, 30 ((3)): (665-677). [PMID:32338327]

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