AF38469 - 10mM in DMSO, high purity , CAS No.1531634-31-7(DMSO)

  • 10mM in DMSO
Item Number
A655208
Grouped product items
SKUSizeAvailabilityPrice Qty
A655208-1ml
1ml
Available within 8-12 weeks(?)
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$308.90

Basic Description

Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsAF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC 50 value of 330 nM.
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC 50 value of 330 nM.

In Vivo

AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:IC50:330 nM (Sortilin)

Associated Targets(Human)

SORT1 Tchem Sortilin (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Canonical SMILES CC1=NC(=CC=C1)NC(=O)C2=C(C=C(C=C2)C(F)(F)F)C(=O)O
Molecular Weight 324.25

Certificates

Certificate of Analysis(COA)

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Related Documents

Solution Calculators