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Afatinib - 95%, high purity , CAS No.439081-18-2

Specifications & Purity: 95%

CAS#: 439081-18-2
Formula: C₂₄H₂₅ClFN₅O₃
Molecular Weight: 485.94
PubChem CID: 10184653

Item Number

A129323

Grouped product items
SKU	Size	Availability	Price
A129323-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$251.90
A129323-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,132.90
A129323-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$5,097.90
A129323-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$18,352.90
A129323-5g	5g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$82,586.90

Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor

Basic Description

Synonyms	Afatinib\|439081-18-2\|850140-72-6\|Tovok\|BIBW2992\|Tomtovok\|BIBW 2992\|BIBW-2992\|Afatinib (BIBW2992)\|(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide\|Afatinib, Free Base\|afatinibum\|BIBW29
Specifications & Purity	95%
Storage Temp	Store at -20°C
Shipped In	Dry ice

Associated Targets

ERBB4 Tclin Receptor tyrosine-protein kinase erbB-4 2 Activities

Discover Target: ERBB4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 8 Activities

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 62 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
INCHI	InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
InChi Key	ULXXDDBFHOBEHA-CWDCEQMOSA-N
Canonical SMILES	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
Isomeric SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
PubChem CID	10184653
Molecular Weight	485.94

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5 results found

Lot Number	Certificate Type	Date	Item
D2311429	Certificate of Analysis	Feb 04, 2023	A129323
D2311434	Certificate of Analysis	Feb 04, 2023	A129323
D2311435	Certificate of Analysis	Feb 04, 2023	A129323
D2311436	Certificate of Analysis	Feb 04, 2023	A129323
D2311440	Certificate of Analysis	Feb 04, 2023	A129323

Pictogram(s)

GHS06,GHS08,GHS09,GHS07

Signal

Danger

Hazard Statements

H319,H301,H410,H372,H361,H362

Precautionary Statements

P305+P351+P338,P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P263,P203,P264+P265,P301+P316,P318,P337+P317,P319

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