Afatinib - 95%, high purity , CAS No.439081-18-2

Item Number

A129323

• Synonyms: BIBW2992 | (2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide | AFATINIB [MI] | AKOS001015518 | BIBW2992 - Afatinib | NSC799327 | NSC-799327 | 850140-72-6 (free base) | Afatinib [USAN:INN] | EX-
• Specifications & Purity: ≥95%
• Biochemical and Physiological Mechanisms: Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC 50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Afatinib (BIBW2992) is an irreversible EGFR/Neu inhibitor with an IC50 of 14 nM. Afatinib is a potent inhibitor of EGFR phosphorylation. Afatinib showed positive results in assays against a variety of human cancer cell lines, including A431, murine NIH-3T3 cells, and breast cancer cell line BT-474.
An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylation