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AFM13, Antibody of CD30;Antibody of Fc fragment of IgG receptor IIIa

Features and benefits
    Item Number
    Ab175448
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    Ab175448-1mg
    		1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,668.90
    Ab175448-5mg
    		5mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $4,668.90
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    View related series
    Click to view target information: FCGR3A Click to view target information: TNFRSF8
    CD30 Antibody Fc fragment of IgG receptor IIIa Antibody

    Basic Description

    Product NameAFM13
    SynonymsAFM 13;AFM-13
    Specifications & PurityMoligand™
    GradeMoligand™
    Action TypeANTIBODY
    Mechanism of actionAntibody of CD30;Antibody of Fc fragment of IgG receptor IIIa

    Product Properties

    CASAb175448

    Associated Targets(Human)

    FCGR3A Tclin Low affinity immunoglobulin gamma Fc region receptor III-A (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    TNFRSF8 Tclin Tumor necrosis factor receptor superfamily member 8 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    TNFRSF8 Tclin Tumor necrosis factor receptor superfamily member 8 (0 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Mechanisms of Action

    Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

    Certificates

    Certificate of Analysis(COA)

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    Related Documents

     SDS

     Specification Sheet

    References

    1. Reusch U, Burkhardt C, Fucek I, Le Gall F, Le Gall M, Hoffmann K, Knackmuss SH, Kiprijanov S, Little M, Zhukovsky EA.  (2014)  A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells..  MAbs,  6  (3): (728-39).  [PMID:24670809] [10.1021/op500134e]
    2. Rothe A, Sasse S, Topp MS, Eichenauer DA, Hummel H, Reiners KS, Dietlein M, Kuhnert G, Kessler J, Buerkle C et al..  (2015)  A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma..  Blood,  125  (26): (4024-31).  [PMID:25887777] [10.1021/op500134e]

    Solution Calculators

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