AG-1024 - ≥98%, high purity , CAS No.65678-07-1, Inhibitor of Insulin-like growth factor I receptor

Item Number

A126115

• Synonyms: 65678-07-1 | ag1024 | Tyrphostin AG 1024 | AG-1024 | AG 1024 | 2-(3-Bromo-5-(tert-butyl)-4-hydroxybenzylidene)malononitrile | 2-(3-bromo-5-tert-butyl-4-hydroxybenzylidene)malononitrile | 2-[(3-bromo-5-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile | NF4XN6A8V9 | C
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: AG1024 (Tyrphostin AG 1024), one selective inhibitor of IGF-1R, was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. AG1024 inhibited the mitogen-activated protein
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of Insulin-like growth factor I receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

AG-1024 (Tyrphostin) inhibits IGF-1R autophosphorylation with IC50 of 7 μM, less potent to IR with IC50 of 57 μM.