The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
AG-1288 - ≥98%, high purity , CAS No.116313-73-6
a tyrosine kinase inhibitor and cell protective agent
Basic Description Synonyms BiomolKI_000017 | AG-1288 | UPCMLD-DP016:002 | NCGC00161598-01 | BMK1-C5 | 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | Tyrphostin AG1288 | AMY25958 | SCHEMBL10144550 | AG 1288 | BiomolKI2_000027 | BRD-K08115555-001-02-8 | HSCI1_000138 | Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description AG-1288 is a tyrosine kinase inhibitor. It has been shown in human amnion cells (IC|50|=21 mM) to block glucocorticoid-induced cytotoxicity, TNFα-induced cytotoxicity, and glucocorticoid-induced COX-2 activity. It has also been reported to protect mice against lipopolysaccharide-induced lethal toxicity. This effect correlates with its ability to block LPS-induced production of nitric oxide in macrophages, and tumor necrosis factor alpha.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile INCHI InChI=1S/C10H5N3O4/c11-4-7(5-12)1-6-2-8(13(16)17)10(15)9(14)3-6/h1-3,14-15H InChi Key KUXOYSZHUFZKHN-UHFFFAOYSA-N Canonical SMILES C1=C(C=C(C(=C1[N+](=O)[O-])O)O)C=C(C#N)C#N Isomeric SMILES C1=C(C=C(C(=C1[N+](=O)[O-])O)O)C=C(C#N)C#N PubChem CID 3856780 Molecular Weight 231.2
Chemical and Physical Properties Solubility Soluble in DMSO (35 mg/mL)
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
