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AG-1288 - ≥98%, high purity , CAS No.116313-73-6
a tyrosine kinase inhibitor and cell protective agent
Basic Description Synonyms 116313-73-6 | AG-1288 | TYRPHOSTIN AG 1288 | 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile | AG 1288 | CHEMBL166486 | Propanedinitrile, 2-[(3,4-dihydroxy-5-nitrophenyl)methylene]- | 2-(3,4-dihydroxy-5-nitrobenzylidene)malononitrile | UPCMLD-DP016:001 | alpha Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description AG-1288 is a tyrosine kinase inhibitor. It has been shown in human amnion cells (IC|50|=21 mM) to block glucocorticoid-induced cytotoxicity, TNFα-induced cytotoxicity, and glucocorticoid-induced COX-2 activity. It has also been reported to protect mice against lipopolysaccharide-induced lethal toxicity. This effect correlates with its ability to block LPS-induced production of nitric oxide in macrophages, and tumor necrosis factor alpha.
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-[(3,4-dihydroxy-5-nitrophenyl)methylidene]propanedinitrile INCHI InChI=1S/C10H5N3O4/c11-4-7(5-12)1-6-2-8(13(16)17)10(15)9(14)3-6/h1-3,14-15H InChi Key KUXOYSZHUFZKHN-UHFFFAOYSA-N Canonical SMILES C1=C(C=C(C(=C1[N+](=O)[O-])O)O)C=C(C#N)C#N Isomeric SMILES C1=C(C=C(C(=C1[N+](=O)[O-])O)O)C=C(C#N)C#N PubChem CID 3856780 Molecular Weight 231.2
Chemical and Physical Properties Solubility Soluble in DMSO (35 mg/mL)
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