Skip to the beginning of the images gallery

AG-490 (Tyrphostin B42) - ≥98%, high purity , CAS No.133550-30-8, Inhibitor of epidermal growth factor receptor

Specifications & Purity: ≥98%

CAS#: 133550-30-8
Formula: C₁₇H₁₄N₂O₃
Molecular Weight: 294.3
MDL number: MFCD00236452
PubChem CID: 5328779

Item Number

A126525

Grouped product items
SKU	Size	Availability	Price
A126525-20mg	20mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$46.90
A126525-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$96.90
A126525-250mg	250mg	In stock	$436.90
A126525-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,571.90

JAK2/3 inhibitor

View related series

epidermal growth factor receptor Inhibitor

Basic Description

Synonyms	133550-30-8\|AG-490\|Tyrphostin B42\|AG 490\|Tyrphostin AG 490\|(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide\|AG490\|Tyrphostin AG490\|N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide\|134036-52-5\|(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enam
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Inhibitor of epidermal growth factor receptor

Names and Identifiers

Pubchem Sid	488195367
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195367
IUPAC Name	(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
INCHI	InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChi Key	TUCIOBMMDDOEMM-RIYZIHGNSA-N
Canonical SMILES	C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N
Isomeric SMILES	C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N
WGK Germany	3
PubChem CID	5328779
Molecular Weight	294.3

PubChem CID

CAS Registry No.

ChEMBL Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

3 results found

Lot Number	Certificate Type	Date	Item
C2313133	Certificate of Analysis	Mar 22, 2023	A126525
J1711005	Certificate of Analysis	Mar 17, 2023	A126525
C2131104	Certificate of Analysis	Jan 13, 2023	A126525

Solubility

DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL

Sensitivity

Light Sensitive,Air Sensitive,Heat Sensitive

Melt Point(°C)

215°C

Pictogram(s)

GHS06,GHS09

Signal

Danger

Hazard Statements

H301,H400

Precautionary Statements

P273,P321,P405,P501,P264,P270,P391,P330,P301+P316

WGK Germany

References

1. Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C, Levitzki A. (1991) Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.. J Med Chem, 34 (6): (1896-907). [PMID:1676428]
2. Zeng Y et al.. (2014) Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis.. Carcinogenesis, 35 (10): (2244-53). [PMID:24925029]
3. Zhang Z et al.. (2021) Neuritin inhibits astrogliosis to ameliorate diabetic cognitive dysfunction.. J Mol Endocrinol, 66 (4): (259-272). [PMID:33729996]
4. Wang Y & Li Y. (2018) MiR-29c inhibits HCV replication via activation of type I IFN response by targeting STAT3 in JFH-1-infected Huh7 cells.. RSC Adv, 8 (15): (8164-8172). [PMID:35542013]
5. Li HN et al.. (2021) Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-a through activating ERK, p38 MAPK, and JAK2/STAT3.. J Neuroinflammation, 18 (150). [PMID:34225736]
6. Guo YJ et al.. (2018) Red nucleus interleukin-1ß evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways.. J Neurosci Res, 96 (12): (1847-1861). [PMID:30216497]

Calculator

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

AG-490 (Tyrphostin B42) - ≥98%, high purity , CAS No.133550-30-8, Inhibitor of epidermal growth factor receptor

Basic Description

Associated Targets

EGFR Tclin Epidermal growth factor receptor 1 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

FAQs and Articles

Product Questions

Product Questions

Reviews

Customer Reviews

References

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculator