AG-490 (Tyrphostin B42) - ≥98%, high purity , CAS No.133550-30-8, Inhibitor of epidermal growth factor receptor

Item Number

A126525

• Synonyms: 133550-30-8 | AG-490 | Tyrphostin B42 | AG 490 | Tyrphostin AG 490 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | AG490 | Tyrphostin AG490 | N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | 134036-52-5 | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enam
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: AG-490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vi
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of epidermal growth factor receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR with IC50 of 0.1 μM, 135-fold more selective for EGFR versus ErbB2, also inhibits JAK2 with no activity to Lck, Lyn, Btk, Syk and Src.
Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells