Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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A421271-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $120.90 |
Potent EGFR-tyrosine kinase inhibitor
Synonyms | AG 555 | TYRPHOSTIN AG 555 | 133550-34-2 | Tyrphostin B46 | Tyrphostin B-46 | AG-555 | ag555 | MLS000069704 | (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-2-propenamide | (e)-2-cyano-3-(3,4-dihydroxyphenyl)-n-(3-phenylpropyl)acrylamide | (E)-2-cyano-3-(3,4-dihydrox |
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Specifications & Purity | 10mM in DMSO |
Biochemical and Physiological Mechanisms | Potent EGFR-tyrosine kinase inhibitor (IC 50 = 700 nM). Blocks Cdk2 activation. Active form of tyrphostin A1 . Induces cell arrest at late G1 phase (IC 50 values are 6.4 and 9.4 μM for HPV16-immortalized and normal keratinocytes respectively). |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
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IUPAC Name | (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)prop-2-enamide |
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INCHI | InChI=1S/C19H18N2O3/c20-13-16(11-15-8-9-17(22)18(23)12-15)19(24)21-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11-12,22-23H,4,7,10H2,(H,21,24)/b16-11+ |
InChi Key | GSQOBTOAOGXIFL-LFIBNONCSA-N |
Canonical SMILES | C1=CC=C(C=C1)CCCNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
Isomeric SMILES | C1=CC=C(C=C1)CCCNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
PubChem CID | 5328770 |
Molecular Weight | 322.36 |
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