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AGK2 - 10mM in DMSO, high purity , CAS No.304896-28-4
Selective reversible cell-permeable sirtuin2 (SIRT2) inhibitor
Basic Description
| Synonyms | AGK2 | 304896-28-4 | AGK-2 | AGK 2 | UNII-DDF0L8606A | DDF0L8606A | 2-Propenamide, 2-cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl- | CHEMBL224864 | SIRT2 Inhibitor, AGK2 | 2-cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide | 2-cyano-3-[5-(2 |
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| Specifications & Purity | Moligand™, 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | Selective reversible cell-permeable sirtuin2 (SIRT2) inhibitor (IC 50 = 3.5 μM). Protects dopamine neurons from α-synuclein toxicity in vivo . Orally active. |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | (E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide |
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| INCHI | InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+ |
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| InChi Key | SVENPFFEMUOOGK-SDNWHVSQSA-N |
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| Canonical SMILES | C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N |
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| Isomeric SMILES | C1=CC2=C(C=CC=N2)C(=C1)NC(=O)/C(=C/C3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)/C#N |
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| PubChem CID | 2130404 |
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| Molecular Weight | 434.27 |
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Chemical and Physical Properties
| Sensitivity | Heat Sensitive；Moisture sensitive |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H319:Causes serious eye irritation |
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| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
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