AICA-Riboside, 5′-Phosphate - ≥95%, high purity , CAS No.3031-94-5

Item Number

A346730

• Synonyms: NSC 283955 | NSC 292227 | ZMP | 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide | 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide | F0X88YW0YK | Z-nucleotide | 5-Aminoimidazole-4-carboxamide-1-?-D-Ribofuranosyl 5'-Monophosphate | EINECS 2
• Specifications & Purity: ≥95%
• Biochemical and Physiological Mechanisms: A 5'- phosphorylated analog of cell permeable AICAR that mimics adenosine monophosphate (AMP). It is an adenylate activated protein kinase (AMPK) activator. In humans, 5-aminoimidazole-4-formamide-1- β—— D-furosyl 5 '- monophosphate (AICAR) has been foun
• Storage Temp: Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads

Product Description

AICA-Riboside, 5′-Phosphate is a monophosphorylated analog of the membrane permeable AICA-Riboside that mimics AMP and behaves as an AMPK (AMP-activated protein kinase) activator. AICA-Riboside, 5′-Phosphate displays similar effects of its parent derivative including stimulating glucose transport in certain skeletal-muscle cell lines.

5-aminoimidazole-4-formamide-1-β-d-ribofuran 5 '-monophosphate (AICAR) is a natural metabolic intermediate in purine biosynthesis, commonly found in all organisms. It is produced by succinyl-Aicar (SAICAR) with the help of adenylate succinase (ASL).

Application：

5-aminoimidazole-4-formamide-1-β-D-ribofuranyl 5 '-monophosphate was used in the study to explore the anticancer effects of nine statins in breast cancer and glioblastoma; AICAR monophosphate is a 5 "-phosphorylated analog of cellular permeable AICAR that mimics AMP. AICAR is an adenosine monophosphate (AMP) activated protein kinase (AMPK) activator/agonist.