A 5'- phosphorylated analog of cell permeable AICAR that mimics adenosine monophosphate (AMP). It is an adenylate activated protein kinase (AMPK) activator.
In humans, 5-aminoimidazole-4-formamide-1- β—— D-furosyl 5 '- monophosphate (AICAR) has been foun
Storage Temp
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
Product Description
AICA-Riboside, 5′-Phosphate is a monophosphorylated analog of the membrane permeable AICA-Riboside that mimics AMP and behaves as an AMPK (AMP-activated protein kinase) activator. AICA-Riboside, 5′-Phosphate displays similar effects of its parent derivative including stimulating glucose transport in certain skeletal-muscle cell lines.
5-aminoimidazole-4-formamide-1-β-d-ribofuran 5 '-monophosphate (AICAR) is a natural metabolic intermediate in purine biosynthesis, commonly found in all organisms. It is produced by succinyl-Aicar (SAICAR) with the help of adenylate succinase (ASL).
Application：
5-aminoimidazole-4-formamide-1-β-D-ribofuranyl 5 '-monophosphate was used in the study to explore the anticancer effects of nine statins in breast cancer and glioblastoma; AICAR monophosphate is a 5 "-phosphorylated analog of cellular permeable AICAR that mimics AMP. AICAR is an adenosine monophosphate (AMP) activated protein kinase (AMPK) activator/agonist.
B2423657