AK-2292 , CAS No.A607472, cereblon;signal transducer and activator of transcription 5A

Item Number

A607472

Grouped product items
SKU	Size	Availability	Price	Qty
A607472-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607472-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,900.90

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Synonyms

AK2292

Specifications & Purity

Moligand™

Grade

Moligand™

Mechanism of action

cereblon;signal transducer and activator of transcription 5A

Associated Targets(Human)

CRBN Tclin Protein cereblon (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

STAT5A Tchem Signal transducer and activator of transcription 5A (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[[2-[[(2S)-1-[(2S)-2-[[3-[5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pent-4-ynyl-methylamino]-3-oxopropyl]-[4-(1,3-thiazol-2-yl)phenyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-1-benzothiophen-5-yl]-difluoromethyl]phosphonic acid
INCHI	InChI=1S/C52H54F2N7O10PS2/c1-51(2,3)44(57-46(65)41-29-33-28-34(16-20-40(33)74-41)52(53,54)72(69,70)71)50(68)60-25-9-13-39(60)49(67)59(35-17-14-32(15-18-35)47-55-23-27-73-47)26-22-43(63)58(4)24-7-5-6-10-31-11-8-12-36-37(31)30-61(48(36)66)38-19-21-42(62)56-45(38)64/h8,11-12,14-18,20,23,27-29,38-39,44H,5,7,9,13,19,21-22,24-26,30H2,1-4H3,(H,57,65)(H,56,62,64)(H2,69,70,71)/t38?,39-,44+/m0/s1
InChi Key	LOPYPDQOHNOVBM-QOIUHGAOSA-N
Canonical SMILES	O=C1NC(CCC1N2C(C3=CC=CC(=C3C2)C#CCCCN(C(CCN(C(=O)[C@H]4N(CCC4)C([C@H](C(C)(C)C)NC(=O)C5=CC6=C(S5)C=CC(=C6)C(F)(F)P(O)(O)=O)=O)C7=CC=C(C=C7)C=8SC=CN8)=O)C)=O)=O
PubChem CID	166594150

References

1. Kaneshige A, Bai L, Wang M, McEachern D, Meagher JL, Xu R, Kirchhoff PD, Wen B, Sun D, Stuckey JA et al.. (2023) Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.. J Med Chem, 66 (4): (2717-2743). [PMID:36735833] [10.1021/op500134e]

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