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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | 4906-68-7 | AKR1C1-IN-1 | 3-bromo-2-hydroxy-5-phenylbenzoic acid | 5-Bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid | 3-bromo-5-phenylsalicylic acid | 3-Bromo-5-phenyl salicylic acid | NSC-109116 | CHEMBL387536 | 5-bromo-4-hydroxybiphenyl-3-carboxylic acid | 5-BROMO-4-H |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Information AKR1C1-IN-1 AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively. Targets AKR1C1 (Cell-free assay); AKR1C2 (Cell-free assay); AKR1C3 (Cell-free assay); AKR1C4 (Cell-free assay) 4 nM(Ki); 87 nM(Ki); 4.2 μM(Ki); 18.2 μM(Ki) |
Associated Targets(Human)
AKR1C2 Tchem Aldo-keto reductase family 1 member C2 (2 Activities)
AKR1C1 Tchem Aldo-keto reductase family 1 member C1 (7 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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AKR1C3 Tchem Aldo-keto-reductase family 1 member C3 (1414 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AKR1C4 Tchem Aldo-keto reductase family 1 member C4 (224 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AKR1C2 Tchem Aldo-keto reductase family 1 member C2 (639 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AKR1C1 Tchem Aldo-keto reductase family 1 member C1 (475 Activities)
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Associated Targets(non-human)
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Names and Identifiers
| IUPAC Name | 3-bromo-2-hydroxy-5-phenylbenzoic acid |
|---|---|
| INCHI | InChI=1S/C13H9BrO3/c14-11-7-9(8-4-2-1-3-5-8)6-10(12(11)15)13(16)17/h1-7,15H,(H,16,17) |
| InChi Key | XVZSXNULHSIRCQ-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC=C(C=C1)C2=CC(=C(C(=C2)Br)O)C(=O)O |
| Isomeric SMILES | C1=CC=C(C=C1)C2=CC(=C(C(=C2)Br)O)C(=O)O |
| PubChem CID | 268734 |
| Molecular Weight | 293.12 |
Certificates
Certificate of Analysis(COA)
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2209180 | Certificate of Analysis | Jun 25, 2022 | A412533 |
| K2209181 | Certificate of Analysis | Jun 25, 2022 | A412533 |
| K2209183 | Certificate of Analysis | Jun 25, 2022 | A412533 |
| K2209184 | Certificate of Analysis | Jun 25, 2022 | A412533 |
Chemical and Physical Properties
| Solubility | Solubility (25°C) In vitro DMSO: 59 mg/mL (201.28 mM); Ethanol: 59 mg/mL (201.28 mM); Water: Insoluble; |
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