Basic Description

Synonyms	Albitiazolium bromide \| 321915-72-4 \| SAR 97276 \| Albitiazolium bromide [INN] \| 3AC0AJ4ILP \| SAR97276A \| SAR-97276A \| 1,12-BIS[4-METHYL-5-(2-HYDROXYETHYL)THIAZOL-3-IUM-3-YL]DODECANE DIBROMIDE \| 3,3'-(Dodecan-1,12-diyl)bis(5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium) di
Specifications & Purity	Moligand™
Grade	Moligand™

Associated Targets(Human)

Jurkat (10389 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium vinckei petteri (380 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	2-[3-[12-[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]dodecyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;dibromide
INCHI	InChI=1S/C24H42N2O2S2.2BrH/c1-21-23(13-17-27)29-19-25(21)15-11-9-7-5-3-4-6-8-10-12-16-26-20-30-24(14-18-28)22(26)2;;/h19-20,27-28H,3-18H2,1-2H3;2*1H/q+2;;/p-2
InChi Key	AFJCGBHHSKAACR-UHFFFAOYSA-L
Canonical SMILES	CC1=C(SC=[N+]1CCCCCCCCCCCC[N+]2=CSC(=C2C)CCO)CCO.[Br-].[Br-]
Isomeric SMILES	CC1=C(SC=[N+]1CCCCCCCCCCCC[N+]2=CSC(=C2C)CCO)CCO.[Br-].[Br-]
Alternate CAS	321915-72-4
PubChem CID	11377022
MeSH Entry Terms	1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane;1,12-bis(4-methyl-5-(2-hydroxyethyl)thiazol-3-ium-3-yl)dodecane dibromide;1,12-bisMHTD;albitiazolium;SAR 97276;SAR-97276;SAR97276

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1. Vial HJ, Wein S, Farenc C, Kocken C, Nicolas O, Ancelin ML, Bressolle F, Thomas A, Calas M. (2004) Prodrugs of bisthiazolium salts are orally potent antimalarials.. Proc Natl Acad Sci USA, 101 (43): (15458-63). [PMID:15492221]
2. Nicolas O, Margout D, Taudon N, Wein S, Calas M, Vial HJ, Bressolle FM. (2005) Pharmacological properties of a new antimalarial bisthiazolium salt, T3, and a corresponding prodrug, TE3.. Antimicrob Agents Chemother, 49 (9): (3631-9). [PMID:16127032]
3. Wein S, Maynadier M, Bordat Y, Perez J, Maheshwari S, Bette-Bobillo P, Tran Van Ba C, Penarete-Vargas D, Fraisse L, Cerdan R et al.. (2012) Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate.. Br J Pharmacol, 166 (8): (2263-76). [PMID:22471905]
4. Held J, Supan C, Salazar CLO, Tinto H, Bonkian LN, Nahum A, Sié A, Abdulla S, Cantalloube C, Djeriou E et al.. (2017) Safety and efficacy of the choline analogue SAR97276 for malaria treatment: results of two phase 2, open-label, multicenter trials in African patients.. Malar J, 16 (1): (188). [PMID:28472957]

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SKU	Size	Availability	Price	Qty
A607496-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607496-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90