Alendronic Acid - ≥98.0%, high purity , CAS No.66376-36-1, Inhibitor of farnesyl diphosphate synthase

Item Number
A136993
Grouped product items
SKUSizeAvailabilityPrice Qty
A136993-1g
1g
In stock
$16.90
A136993-5g
5g
In stock
$63.90
A136993-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$189.90

Basic Description

Synonyms(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid | (4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid | Acido alendronico [INN-Spanish] | ALENDRONATE (MART.) | 1yhm | Q420057 | alpha-hydroxy-delta-aminobutylidenediphosphonic acid | BPH 1 | 4-Amino-1-
Specifications & PurityMoligand™, ≥98%
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of farnesyl diphosphate synthase
Product Description

Alendronate acid is an inhibitor of FDPS. It is a bisphosphonate that inhibits osteoclast-mediated bone resorption. Unlike pyrophosphate, the endogenous regulator of bone turnover to which it is chemically related, alendronate specifically inhibits osteoclastic osteoclastic bone resorption, having no effect on mineralization of bone newly formed by osteoblasts.
An inhibitor of FDPS

Associated Targets(Human)

FDPS Tclin Farnesyl pyrophosphate synthase (10 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FDPS Tclin Farnesyl diphosphate synthase (1240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCGR Tclin Glucagon receptor (2563 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Htr7 Serotonin 7 (5-HT7) receptor (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dictyostelium discoideum (81 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Farnesyl pyrophosphate synthase (85 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MC3T3-E1 (421 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488179658
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179658
IUPAC Name (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
INCHI InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12)
InChi Key OGSPWJRAVKPPFI-UHFFFAOYSA-N
Canonical SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
Isomeric SMILES C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
RTECS SZ6521833
Alternate CAS 121268-17-5
PubChem CID 2088
Molecular Weight 249.1
Reaxy-Rn 2275403

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

19 results found

Lot NumberCertificate TypeDateItem
H2205713Certificate of AnalysisMay 09, 2024 A136993
H2205712Certificate of AnalysisMay 07, 2024 A136993
A2211264Certificate of AnalysisOct 16, 2023 A136993
I2311168Certificate of AnalysisJul 19, 2023 A136993
I2311150Certificate of AnalysisJul 19, 2023 A136993
I2311149Certificate of AnalysisJul 19, 2023 A136993
G2320303Certificate of AnalysisJun 05, 2023 A136993
G2320304Certificate of AnalysisJun 05, 2023 A136993
G2320305Certificate of AnalysisJun 05, 2023 A136993
G2320307Certificate of AnalysisJun 05, 2023 A136993
G2320308Certificate of AnalysisJun 05, 2023 A136993
J2010113Certificate of AnalysisAug 11, 2022 A136993
G2220411Certificate of AnalysisJul 25, 2022 A136993
E2315393Certificate of AnalysisJul 25, 2022 A136993
H2205714Certificate of AnalysisJul 25, 2022 A136993
D2310190Certificate of AnalysisJul 25, 2022 A136993
E2315384Certificate of AnalysisJul 25, 2022 A136993
A2211273Certificate of AnalysisJan 05, 2022 A136993
A2211272Certificate of AnalysisJan 05, 2022 A136993

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Chemical and Physical Properties

Melt Point(°C)235°C(dec.)(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS05,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H314:Causes severe skin burns and eye damage

H302:Harmful if swallowed

H318:Causes serious eye damage

H290:May be corrosive to metals

H361:Suspected of damaging fertility or the unborn child

H371:May cause damage to organs

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P363:Wash contaminated clothing before reuse.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P234:Keep only in original container.

P390:Absorb spillage to prevent material damage.

P406:Store in corrosive resistant/... container with a resistant inner liner.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P318:if exposed or concerned, get medical advice.

P317:Get emergency medical help.

P337+P317:If eye irritation persists: Get medical help.

P308+P316:IF exposed or concerned: Get emergency medical help immediately.

P332+P317:If skin irritation occurs: Get medical help.

P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes.

P316:Get emergency medical help immediately.

RTECS SZ6521833
Reaxy-Rn 2275403
Merck Index 229

Related Documents

Citations of This Product

1. Wentao Shi, Yan Gao, Yiqing Wu, Jiaqi Sun, Bai Xu, Xiaojie Lu, Qing Wang.  (2023)  A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  249  (126072).  [PMID:37524274] [10.1016/j.ijbiomac.2023.126072]
2. Yan Huang, Maowen Chen, Yiding Shen, Xinkun Shen, Menghuan Li, Yanan Li, Yuan Liu, Kaiyong Cai, Zhong Luo, Yan Hu.  (2023)  Bone-targeting cell membrane-engineered CaCO3-based nanoparticles restore local bone homeostasis for microenvironment-responsive osteoporosis treatment.  CHEMICAL ENGINEERING JOURNAL,  470  (144145).  [PMID:] [10.1016/j.cej.2023.144145]
3. Yonghui Wu, Lu Yang, Qianqian Wu, Qingshan Liu, Ling Zou, Xiaochao Yang, Keyong Tang.  (2023)  Regulation of the Oxidase Mimetic Activity of Ceria Nanoparticles by Buffer Composition.  CHEMISTRY-A EUROPEAN JOURNAL,  29  (29): (e202204071).  [PMID:36879435] [10.1002/chem.202204071]
4. Yimin Niu, Hongbin Yang, Zhenyan Yu, Cuicui Gao, Shuaishuai Ji, Jie Yan, Lei Han, Qiang Huo, Ming Xu, Yang Liu.  (2022)  Intervention with the Bone-Associated Tumor Vicious Cycle through Dual-Protein Therapeutics for Treatment of Skeletal-Related Events and Bone Metastases.  ACS Nano,  16  (2): (2209–2223).  [PMID:35077154] [10.1021/acsnano.1c08269]
5. Shan Zhang, Ruiqi Liang, Kun Xu, Shurong Zheng, Somnath Mukherjee, Peng Liu, Changhao Wang, Yashao Chen.  (2022)  Construction of multifunctional micro-patterned PALNMA/PDADMAC/PEGDA hydrogel and intelligently responsive antibacterial coating HA/BBR on Mg alloy surface for orthopedic application.  Materials Science & Engineering C-Materials for Biological Applications,  132  (112636).  [PMID:35148866] [10.1016/j.msec.2021.112636]
6. Zhenyu Zhao, Gen Li, Huitong Ruan, Keyi Chen, Zhengwei Cai, Guanghua Lu, Runmin Li, Lianfu Deng, Ming Cai, Wenguo Cui.  (2021)  Capturing Magnesium Ions via Microfluidic Hydrogel Microspheres for Promoting Cancellous Bone Regeneration.  ACS Nano,  15  (8): (13041–13054).  [PMID:34342981] [10.1021/acsnano.1c02147]
7. Lei Chen, Yufei Tang, Kang Zhao, Xiang Zha, Min Wei, Quanchang Tan, Zixiang Wu.  (2021)  Sequential release of double drug (graded distribution) loaded gelatin microspheres/PMMA bone cement.  Journal of Materials Chemistry B,  (2): (508-522).  [PMID:33305784] [10.1039/D0TB01452D]
8. Xiaonan Zhang, Kang Chen, Bo Wei, Xingwang Liu, Zeming Lei, Xizhuang Bai.  (2016)  Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway.  CHEMICO-BIOLOGICAL INTERACTIONS,  256  (188).  [PMID:27387537] [10.1016/j.cbi.2016.07.003]
9. Yayu Wang,Jie Yao,Lizhao Cai,Tong Liu,Xiaogang Wang,Ye Zhang,Zhiying Zhou,Tingwei Li,Minyi Liu,Renfa Lai,Xiangning Liu.  (2020-10-30)  Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy..  International journal of nanomedicine,  15  (7967-7977).  [PMID:33116512]

References

1. Wentao Shi, Yan Gao, Yiqing Wu, Jiaqi Sun, Bai Xu, Xiaojie Lu, Qing Wang.  (2023)  A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  249  (126072).  [PMID:37524274] [10.1016/j.ijbiomac.2023.126072]
2. Yan Huang, Maowen Chen, Yiding Shen, Xinkun Shen, Menghuan Li, Yanan Li, Yuan Liu, Kaiyong Cai, Zhong Luo, Yan Hu.  (2023)  Bone-targeting cell membrane-engineered CaCO3-based nanoparticles restore local bone homeostasis for microenvironment-responsive osteoporosis treatment.  CHEMICAL ENGINEERING JOURNAL,  470  (144145).  [PMID:] [10.1016/j.cej.2023.144145]
3. Yonghui Wu, Lu Yang, Qianqian Wu, Qingshan Liu, Ling Zou, Xiaochao Yang, Keyong Tang.  (2023)  Regulation of the Oxidase Mimetic Activity of Ceria Nanoparticles by Buffer Composition.  CHEMISTRY-A EUROPEAN JOURNAL,  29  (29): (e202204071).  [PMID:36879435] [10.1002/chem.202204071]
4. Yimin Niu, Hongbin Yang, Zhenyan Yu, Cuicui Gao, Shuaishuai Ji, Jie Yan, Lei Han, Qiang Huo, Ming Xu, Yang Liu.  (2022)  Intervention with the Bone-Associated Tumor Vicious Cycle through Dual-Protein Therapeutics for Treatment of Skeletal-Related Events and Bone Metastases.  ACS Nano,  16  (2): (2209–2223).  [PMID:35077154] [10.1021/acsnano.1c08269]
5. Shan Zhang, Ruiqi Liang, Kun Xu, Shurong Zheng, Somnath Mukherjee, Peng Liu, Changhao Wang, Yashao Chen.  (2022)  Construction of multifunctional micro-patterned PALNMA/PDADMAC/PEGDA hydrogel and intelligently responsive antibacterial coating HA/BBR on Mg alloy surface for orthopedic application.  Materials Science & Engineering C-Materials for Biological Applications,  132  (112636).  [PMID:35148866] [10.1016/j.msec.2021.112636]
6. Zhenyu Zhao, Gen Li, Huitong Ruan, Keyi Chen, Zhengwei Cai, Guanghua Lu, Runmin Li, Lianfu Deng, Ming Cai, Wenguo Cui.  (2021)  Capturing Magnesium Ions via Microfluidic Hydrogel Microspheres for Promoting Cancellous Bone Regeneration.  ACS Nano,  15  (8): (13041–13054).  [PMID:34342981] [10.1021/acsnano.1c02147]
7. Lei Chen, Yufei Tang, Kang Zhao, Xiang Zha, Min Wei, Quanchang Tan, Zixiang Wu.  (2021)  Sequential release of double drug (graded distribution) loaded gelatin microspheres/PMMA bone cement.  Journal of Materials Chemistry B,  (2): (508-522).  [PMID:33305784] [10.1039/D0TB01452D]
8. Xiaonan Zhang, Kang Chen, Bo Wei, Xingwang Liu, Zeming Lei, Xizhuang Bai.  (2016)  Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway.  CHEMICO-BIOLOGICAL INTERACTIONS,  256  (188).  [PMID:27387537] [10.1016/j.cbi.2016.07.003]
9. Yayu Wang,Jie Yao,Lizhao Cai,Tong Liu,Xiaogang Wang,Ye Zhang,Zhiying Zhou,Tingwei Li,Minyi Liu,Renfa Lai,Xiangning Liu.  (2020-10-30)  Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy..  International journal of nanomedicine,  15  (7967-7977).  [PMID:33116512]

Solution Calculators