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Aliskiren Hemifumarate - ≥98%, high purity , Renin inhibitor, CAS No.173334-58-2, Renin inhibitor

≥98%

CAS#: 173334-58-2
Formula: C₃₀H₅₃N₃O₆·1/2C₄H₄O₄
Molecular Weight: 609.83
PubChem CID: 6918427
PubChem SID: 488195878

Item Number

A129231

Grouped product items
SKU	Size	Availability	Price
A129231-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$64.90
A129231-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$142.90
A129231-100mg	100mg	In stock	$234.90
A129231-250mg	250mg	In stock	$528.90
A129231-500mg	500mg	In stock	$951.90
A129231-1g	1g	In stock	$1,713.90
A129231-5g	5g	In stock	$7,709.90

Potent renin inhibitor; antihypertensive

Basic Description

Synonyms	Aliskiren hemifumarate\|173334-58-2\|Tekturna\|Aliskiren fumarate\|Aliskiren (hemifumarate)\|Enviage\|Riprazo\|SPP-100B\|Sprimeo\|UNII-C8A0P8G029\|CHEBI:53777\|C8A0P8G029\|NSC-759185\|ALISKIREN (AS FUMARATE)\|NSC 759185\|CGP 60536\|TEKAMLO COMPONENT ALISKIREN HEMIFUMARAT
Specifications & Purity	≥98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Action Type	INHIBITOR
Mechanism of action	Renin inhibitor
Product Description	Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

Names and Identifiers

Pubchem Sid	488195878
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195878
IUPAC Name	(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide;(E)-but-2-enedioic acid
INCHI	InChI=1S/2C30H53N3O6.C4H4O4/c21-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h210-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1
InChi Key	KLRSDBSKUSSCGU-KRQUFFFQSA-N
Canonical SMILES	CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O
Isomeric SMILES	CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=C/C(=O)O)\C(=O)O
PubChem CID	6918427
Molecular Weight	609.83

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
G2208061	Certificate of Analysis	May 09, 2024	A129231
G2208062	Certificate of Analysis	Apr 07, 2024	A129231
G2208063	Certificate of Analysis	Apr 07, 2024	A129231
G2208064	Certificate of Analysis	Apr 07, 2024	A129231
G2208065	Certificate of Analysis	Apr 07, 2024	A129231
C23031331	Certificate of Analysis	Mar 31, 2023	A129231
A1516024	Certificate of Analysis	Dec 09, 2022	A129231

Solubility

Solvent:water, Max Conc. mg/mL: 60.98, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 60.98, Max Conc. mM: 100

Sensitivity

Heat, light sensitive

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H373:Causes damage to organs through prolonged or repeated exposure H302:Harmful if swallowed H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

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Aliskiren Hemifumarate - ≥98%, high purity , Renin inhibitor, CAS No.173334-58-2, Renin inhibitor

Basic Description

Associated Targets

REN Tclin Renin 2 Activities