Alizarin violet - 10mM in DMSO, high purity , CAS No.2103-64-2

Item Number

A422559

Grouped product items
SKU	Size	Availability	Price	Qty
A422559-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Inhibitor of Gβ/γsignaling

Basic Description

Synonyms	Gallein \| 2103-64-2 \| Alizarin violet \| Pyrogallolphthalein \| Mordant violet 25 \| 3',4',5',6'-Tetrahydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one \| C.I. Mordant Violet 25 \| Pyrogallol phthalein \| 4,5-Dihydroxyfluorescein \| C.I. 45445 \| 3',4',5',6'-Tetrahydroxyfluoran \| Spi
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Inhibitor of G proteinβγsubunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Gallein is a cell-permeable xanthene compound that binds to Gβγ with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities. Gallein is reported to exhibit prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model. Gallein is an inhibitor of G β and G γ An inhibitor of Gβγ-dependent cellular activities which binds to Gβγ with high affinity

Associated Targets(Human)

GNG2 Tbio Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GNB1 Tbio Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1/gamma-2 (71 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	3',4',5',6'-tetrahydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
INCHI	InChI=1S/C20H12O7/c21-13-7-5-11-17(15(13)23)26-18-12(6-8-14(22)16(18)24)20(11)10-4-2-1-3-9(10)19(25)27-20/h1-8,21-24H
InChi Key	PHLYOKFVXIVOJC-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=O)OC23C4=C(C(=C(C=C4)O)O)OC5=C3C=CC(=C5O)O
Isomeric SMILES	C1=CC=C2C(=C1)C(=O)OC23C4=C(C(=C(C=C4)O)O)OC5=C3C=CC(=C5O)O
PubChem CID	73685
Molecular Weight	364.3
Beilstein	19(3/4)3147
Reaxy-Rn	58028

Refractive Index

1.87

Boil Point(°C)

687.42°C at 760mmHg

Melt Point(°C)

259.33°C

Reaxy-Rn

58028

Merck Index

4344

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Basic Description