ALLN - ≥95%, high purity , CAS No.110044-82-1

  • ≥95%
Item Number
A274819
Grouped product items
SKUSizeAvailabilityPrice Qty
A274819-5mg
5mg
In stock
$58.90
A274819-10mg
10mg
In stock
$88.90
A274819-25mg
25mg
In stock
$187.90
A274819-50mg
50mg
In stock
$296.90
A274819-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$474.90

Potent, cell-permeable cysteine proteinase inhibitor

Basic Description

SynonymsCalpain inhibitor I | 110044-82-1 | MG-101 | Acetylleucyl-leucyl-norleucinal | N-Ac-Leu-leu-norleucinal | Ac-Leu-leu-nle-al | N-acetylleucylleucylnorleucinal | CHEBI:2423 | CHEMBL304784 | MG101 | MG 101 | Calpain inhibitor I;Ac-LLnL-CHO;ALLN | (2S)-2-[(2S)-2-acetamido-4-methylpe
Specifications & Purity≥95%
Biochemical and Physiological MechanismsPotent, cell-permeable cysteine proteinase inhibitor (K i values are 190 (calpain I), 220 (calpain II), 150 (cathepsin B) nM and 500 pM (cathepsin L). Promotes Bax-dependent apoptosis in cancer cells. Antitumor agent. Calpain Inhibitor I inhibits tumor ne
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Describtion:

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.


Product Application:
Calpain Inhibitor I have been used: as a component of protease inhibitor cocktail for gel shift analysis for treating HeLa cell cultures for inhibition of 26 S proteasome in 26 S proteasome inhibition assays

Associated Targets(Human)

CTSB Tchem Cathepsin B (3822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP5 Tchem Ubiquitin carboxyl-terminal hydrolase 5 (172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CFL1 Tbio Cofilin-1 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Abcb1b P-glycoprotein 1 (174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAPN1 Calpain 1 (219 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Impa1 Inositol monophosphatase 1 (16203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name (2S)-2-acetamido-4-methyl-N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]pentanamide
INCHI InChI=1S/C20H37N3O4/c1-7-8-9-16(12-24)22-19(26)18(11-14(4)5)23-20(27)17(10-13(2)3)21-15(6)25/h12-14,16-18H,7-11H2,1-6H3,(H,21,25)(H,22,26)(H,23,27)/t16-,17-,18-/m0/s1
InChi Key FMYKJLXRRQTBOR-BZSNNMDCSA-N
Canonical SMILES CCCCC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C
Isomeric SMILES CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C
PubChem CID 443118
Molecular Weight 383.54

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot NumberCertificate TypeDateItem
C2204068Certificate of AnalysisSep 20, 2023 A274819
C2204087Certificate of AnalysisSep 20, 2023 A274819
C2204101Certificate of AnalysisSep 20, 2023 A274819
C2204164Certificate of AnalysisDec 13, 2022 A274819
C2204165Certificate of AnalysisDec 13, 2022 A274819

Chemical and Physical Properties

SolubilitySoluble in DMSO to 50 mM and in ethanol

Safety and Hazards(GHS)

Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P271:Use only outdoors or in a well-ventilated area.

Related Documents

References

1. Joy-Immediato M et al..  (2021)  Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions..  Front Cell Dev Biol,  (669086).  [PMID:34222239]

Solution Calculators