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ALLO-2 - 99%, high purity , CAS No.1357350-60-7

Item Number

A649877

Grouped product items
SKU	Size	Availability	Price	Qty
A649877-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$350.90
A649877-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90

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Basic Description

Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC 50 of 6 nM.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC 50 of 6 nM Form:Solid IC50& Target:IC50: Smo

SMO Tclin Smoothened homolog (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	N-[4-[4-(trifluoromethoxy)phenyl]pyrimidin-2-yl]-1H-indazol-5-amine
INCHI	InChI=1S/C18H12F3N5O/c19-18(20,21)27-14-4-1-11(2-5-14)15-7-8-22-17(25-15)24-13-3-6-16-12(9-13)10-23-26-16/h1-10H,(H,23,26)(H,22,24,25)
InChi Key	QTYGEBIJNWMVCW-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1C2=NC(=NC=C2)NC3=CC4=C(C=C3)NN=C4)OC(F)(F)F
Isomeric SMILES	C1=CC(=CC=C1C2=NC(=NC=C2)NC3=CC4=C(C=C3)NN=C4)OC(F)(F)F
PubChem CID	76848956
Molecular Weight	371.3

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Solubility	DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)

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