Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A105386-5g | 5g | In stock | $64.90 | |
A105386-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $77.90 | |
A105386-25g | 25g | In stock | $175.90 | |
A105386-100g | 100g | In stock | $631.90 | |
A105386-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $2,843.90 |
Xanthine oxidase inhibitor
Synonyms | HPP | 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro- | Dabrosin | DTXSID50892275 | Xanturat | 4-Hydroxypyrazolyl(3,4-d)pyrimidine | O11481 | Zyloric | 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one | 1H-pyrazolo[3,4-d]pyrimidin-4(2H)-one | 4-Hydroxypyrazo |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Xanthine oxidase inhibitor (IC 50 = 0.2 - 50 μM). Anti-hyperuricemic purine analog. Inhibits uric acid production in vivo. Neuroprotective. Active in vivo . |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Xanthine dehydrogenase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Allopurinol is an anti-urolithic Xanthine oxidase inhibitor that decreases uric acid production. |
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IUPAC Name | 1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one |
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INCHI | InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10) |
InChi Key | OFCNXPDARWKPPY-UHFFFAOYSA-N |
Canonical SMILES | C1=NNC2=C1C(=O)NC=N2 |
Isomeric SMILES | C1=NNC2=C1C(=O)NC=N2 |
WGK Germany | 2 |
RTECS | UR0785000 |
PubChem CID | 135401907 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 136.11 |
Beilstein | 26(3/4)4298 |
Reaxy-Rn | 608611 |
DrugBank Ligand | DB00437 |
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PubChem CID | 135401907 |
CAS Registry No. | 315-30-0 |
ChEMBL Ligand | CHEMBL1467 |
Wikipedia | Allopurinol |
DrugCentral Ligand | 124 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2420008 | Certificate of Analysis | Mar 26, 2024 | A105386 |
D2403683 | Certificate of Analysis | Mar 11, 2024 | A105386 |
D2403684 | Certificate of Analysis | Mar 11, 2024 | A105386 |
E2310740 | Certificate of Analysis | Feb 26, 2022 | A105386 |
K2301039 | Certificate of Analysis | Feb 26, 2022 | A105386 |
K2301038 | Certificate of Analysis | Feb 26, 2022 | A105386 |
J2323105 | Certificate of Analysis | Feb 26, 2022 | A105386 |
H2329112 | Certificate of Analysis | Feb 26, 2022 | A105386 |
G2319050 | Certificate of Analysis | Feb 26, 2022 | A105386 |
G2307492 | Certificate of Analysis | Feb 26, 2022 | A105386 |
E2326331 | Certificate of Analysis | Feb 26, 2022 | A105386 |
E2310743 | Certificate of Analysis | Feb 26, 2022 | A105386 |
D2418065 | Certificate of Analysis | Feb 26, 2022 | A105386 |
C2215381 | Certificate of Analysis | Feb 26, 2022 | A105386 |
C2215377 | Certificate of Analysis | Feb 26, 2022 | A105386 |
C2215368 | Certificate of Analysis | Feb 26, 2022 | A105386 |
C2215351 | Certificate of Analysis | Feb 26, 2022 | A105386 |
A2221059 | Certificate of Analysis | Nov 02, 2021 | A105386 |
J2129366 | Certificate of Analysis | Nov 02, 2021 | A105386 |
Solubility | Insoluble in water; Degree of Solubility in water: 0.48 g/l 25 °C; Insoluble in Chloroform,Ether,Ethanol |
---|---|
Melt Point(°C) | 384°C |
Pictogram(s) | GHS06, GHS07 |
---|---|
Signal | Danger |
Hazard Statements | H301:Toxic if swallowed H317:May cause an allergic skin reaction |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 2 |
RTECS | UR0785000 |
Reaxy-Rn | 608611 |
Class | 6.1 |
Merck Index | 279 |
Starting at $266.90
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1. Jiana Du, Na Wang, Dehong Yu, Pei He, Yu Gao, Yanbei Tu, Yanfang Li. (2023) Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters. PHYTOMEDICINE, (155305). [PMID:38176275] |
2. Jie Xiong, Ya-ying Wang, Muhammad Yousaf, Dong-mei Liu. (2023) Improvement of Physicochemical Properties and Flavor of Pickled Radish through the Use of a Direct-Vat Set Starter Consisting of Lactiplantibacillus Plantarum and Leuconostoc Mesenteroides. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, [PMID:21153684] |
3. Yawen Wang, Longjian Zhou, Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban, Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang. (2023) Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction. Marine Drugs, 21 (10): (502). [PMID:37888437] |
4. Xueqin Wang, Zhenzhen Cui, Yuan Luo, Yu Huang, Xinbin Yang. (2023) In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3′-sulfonate. FOOD AND CHEMICAL TOXICOLOGY, 177 (113854). [PMID:37230458] |
5. Jiling Song, Minghui Chen, Fanlei Meng, Jiahui Chen, Zhanwei Wang, Yong Zhang, Jing Cui, Jing Wang, Dongfang Shi. (2023) Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 299 (122861). [PMID:37209475] |
6. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin. (2023) Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies. IET Nanobiotechnology, 17 (4): (368-375). [PMID:37153957] |
7. Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi, Ying-Hua Zhang. (2023) Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein. FOOD RESEARCH INTERNATIONAL, 169 (112882). [PMID:37254330] |
8. Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang. (2023) In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 232 (115415). [PMID:37120975] |
9. Jiling Song, Zhanwei Wang, Yu Chi, Yong Zhang, Chenyi Fang, Yuting Shu, Jing Cui, Helong Bai, Jing Wang. (2023) Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase. BIOORGANIC CHEMISTRY, 133 (106394). [PMID:36801789] |
10. Yingling Sui, Deping Xu, Xiulan Sun. (2023) Identification of anti-hyperuricemic components from Coix seed. Food Bioscience, 52 (102461). [PMID:] |
11. Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich. (2023) Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels. Biomaterials Science, 11 (5): (1704-1713). [PMID:36628631] |
12. Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian, Guiming Fu. (2022) Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz. Food & Function, 13 (22): (11780-11793). [PMID:36300542] |
13. Gao Tianshu, Xu Jin, Xiao Yuxiao, Li Jiaqi, Hu Weifeng, Su Xiaoyu, Shen Xudong, Yu Wan, Chen Zhen, Huang Baosheng, Li Honglei, Wang Xing. (2022) Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia. Frontiers in Pharmacology, 13 [PMID:36120294] |
14. Yawen Lian, Xiang Yuan, Yandan Wang, Lin Wei. (2022) Highly sensitive visual colorimetric sensor for xanthine oxidase detection by using MnO2-nanosheet-modified gold nanoparticles. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 276 (121219). [PMID:35397450] |
15. Rui Sun, Juan Kan, Huahao Cai, Jinhai Hong, Changhai Jin, Man Zhang. (2022) In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia. JOURNAL OF FOOD BIOCHEMISTRY, 46 (2): (e14049). [PMID:34981522] |
1. Pini M et al.. (2021) Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure.. Aging Cell, 20 (8): (e13421). [PMID:34278707] |
2. Jiana Du, Na Wang, Dehong Yu, Pei He, Yu Gao, Yanbei Tu, Yanfang Li. (2023) Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters. PHYTOMEDICINE, (155305). [PMID:38176275] |
3. Jie Xiong, Ya-ying Wang, Muhammad Yousaf, Dong-mei Liu. (2023) Improvement of Physicochemical Properties and Flavor of Pickled Radish through the Use of a Direct-Vat Set Starter Consisting of Lactiplantibacillus Plantarum and Leuconostoc Mesenteroides. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, [PMID:21153684] |
4. Yawen Wang, Longjian Zhou, Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban, Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang. (2023) Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction. Marine Drugs, 21 (10): (502). [PMID:37888437] |
5. Xueqin Wang, Zhenzhen Cui, Yuan Luo, Yu Huang, Xinbin Yang. (2023) In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3′-sulfonate. FOOD AND CHEMICAL TOXICOLOGY, 177 (113854). [PMID:37230458] |
6. Jiling Song, Minghui Chen, Fanlei Meng, Jiahui Chen, Zhanwei Wang, Yong Zhang, Jing Cui, Jing Wang, Dongfang Shi. (2023) Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 299 (122861). [PMID:37209475] |
7. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin. (2023) Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies. IET Nanobiotechnology, 17 (4): (368-375). [PMID:37153957] |
8. Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi, Ying-Hua Zhang. (2023) Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein. FOOD RESEARCH INTERNATIONAL, 169 (112882). [PMID:37254330] |
9. Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang. (2023) In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 232 (115415). [PMID:37120975] |
10. Jiling Song, Zhanwei Wang, Yu Chi, Yong Zhang, Chenyi Fang, Yuting Shu, Jing Cui, Helong Bai, Jing Wang. (2023) Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase. BIOORGANIC CHEMISTRY, 133 (106394). [PMID:36801789] |
11. Yingling Sui, Deping Xu, Xiulan Sun. (2023) Identification of anti-hyperuricemic components from Coix seed. Food Bioscience, 52 (102461). [PMID:] |
12. Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich. (2023) Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels. Biomaterials Science, 11 (5): (1704-1713). [PMID:36628631] |
13. Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian, Guiming Fu. (2022) Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz. Food & Function, 13 (22): (11780-11793). [PMID:36300542] |
14. Gao Tianshu, Xu Jin, Xiao Yuxiao, Li Jiaqi, Hu Weifeng, Su Xiaoyu, Shen Xudong, Yu Wan, Chen Zhen, Huang Baosheng, Li Honglei, Wang Xing. (2022) Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia. Frontiers in Pharmacology, 13 [PMID:36120294] |
15. Yawen Lian, Xiang Yuan, Yandan Wang, Lin Wei. (2022) Highly sensitive visual colorimetric sensor for xanthine oxidase detection by using MnO2-nanosheet-modified gold nanoparticles. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 276 (121219). [PMID:35397450] |
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