Allopurinol - 98%, high purity , Xanthine dehydrogenase inhibitor, CAS No.315-30-0, Xanthine dehydrogenase inhibitor

Item Number
A105386
Grouped product items
SKUSizeAvailabilityPrice Qty
A105386-5g
5g
In stock
$15.90
A105386-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$19.90
A105386-25g
25g
In stock
$29.90
A105386-100g
100g
In stock
$83.90
A105386-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$293.90

Xanthine oxidase inhibitor

Basic Description

SynonymsHPP | 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro- | Dabrosin | DTXSID50892275 | Xanturat | 4-Hydroxypyrazolyl(3,4-d)pyrimidine | O11481 | Zyloric | 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one | 1H-pyrazolo[3,4-d]pyrimidin-4(2H)-one | 4-Hydroxypyrazo
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsXanthine oxidase inhibitor (IC 50 = 0.2 - 50 μM). Anti-hyperuricemic purine analog. Inhibits uric acid production in vivo. Neuroprotective. Active in vivo .
Shipped InNormal
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionXanthine dehydrogenase inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Allopurinol is an anti-urolithic Xanthine oxidase inhibitor that decreases uric acid production.
An anti-urolithic Xanthine oxidase inhibitor

Associated Targets(Human)

XDH Tclin Xanthine dehydrogenase/oxidase (11 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
INSR Tclin Insulin receptor (5558 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD4 Tchem Dopamine D4 receptor (7907 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CALCR Tclin Calcitonin receptor (2215 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CRHR1 Tclin Corticotropin releasing factor receptor 1 (2996 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ltc4s Leukotriene C4 synthase (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Sigmar1 Sigma opioid receptor (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ntsr1 Neurotensin receptor 1 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bdkrb1 Bradykinin B1 receptor (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nos2 Nitric oxide synthase, inducible (3573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pnp Purine nucleoside phosphorylase (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Acinetobacter baumannii (41033 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pneumocystis carinii (749 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania infantum (5912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptosporidium parvum (1150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania amazonensis (3813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania major (2877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania mexicana (936 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichomonas vaginalis (2376 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus anthracis (2936 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Xdh Xanthine dehydrogenase/oxidase (52 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Glra2 Glycine receptor (1745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
stxA Shiga toxin subunit A (82 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 1,5-dihydropyrazolo[3,4-d]pyrimidin-4-one
INCHI InChI=1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)
InChi Key OFCNXPDARWKPPY-UHFFFAOYSA-N
Canonical SMILES C1=NNC2=C1C(=O)NC=N2
Isomeric SMILES C1=NNC2=C1C(=O)NC=N2
WGK Germany 2
RTECS UR0785000
PubChem CID 135401907
UN Number 2811
Packing Group I
Molecular Weight 136.11
Beilstein 26(3/4)4298
Reaxy-Rn 608611

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

22 results found

Lot NumberCertificate TypeDateItem
L2410267Certificate of AnalysisDec 02, 2024 A105386
L2410261Certificate of AnalysisDec 02, 2024 A105386
D2420008Certificate of AnalysisMar 26, 2024 A105386
D2403683Certificate of AnalysisMar 11, 2024 A105386
D2403684Certificate of AnalysisMar 11, 2024 A105386
E2326331Certificate of AnalysisFeb 26, 2022 A105386
K2420145Certificate of AnalysisFeb 26, 2022 A105386
K2301039Certificate of AnalysisFeb 26, 2022 A105386
K2301038Certificate of AnalysisFeb 26, 2022 A105386
J2323105Certificate of AnalysisFeb 26, 2022 A105386
H2329112Certificate of AnalysisFeb 26, 2022 A105386
G2319050Certificate of AnalysisFeb 26, 2022 A105386
G2307492Certificate of AnalysisFeb 26, 2022 A105386
E2310743Certificate of AnalysisFeb 26, 2022 A105386
E2310740Certificate of AnalysisFeb 26, 2022 A105386
D2418065Certificate of AnalysisFeb 26, 2022 A105386
C2215381Certificate of AnalysisFeb 26, 2022 A105386
C2215377Certificate of AnalysisFeb 26, 2022 A105386
C2215368Certificate of AnalysisFeb 26, 2022 A105386
C2215351Certificate of AnalysisFeb 26, 2022 A105386
A2221059Certificate of AnalysisNov 02, 2021 A105386
J2129366Certificate of AnalysisNov 02, 2021 A105386

Show more⌵

Chemical and Physical Properties

SolubilityInsoluble in water; Degree of Solubility in water: 0.48 g/l 25 °C; Insoluble in Chloroform,Ether,Ethanol
Melt Point(°C)384°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 2
RTECS UR0785000
Reaxy-Rn 608611
Class 6.1
Merck Index 279

Related Documents

Alternative Products

Citations of This Product

1. Jiana Du, Na Wang, Dehong Yu, Pei He, Yu Gao, Yanbei Tu, Yanfang Li.  (2023)  Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.  PHYTOMEDICINE,    (155305).  [PMID:38176275] [10.1016/j.phymed.2023.155305]
2. Jie Xiong, Ya-ying Wang, Muhammad Yousaf, Dong-mei Liu.  (2023)  Improvement of Physicochemical Properties and Flavor of Pickled Radish through the Use of a Direct-Vat Set Starter Consisting of Lactiplantibacillus Plantarum and Leuconostoc Mesenteroides.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,      [PMID:21153684] [10.1111/ijfs.16731]
3. Yawen Wang, Longjian Zhou, Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban, Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang.  (2023)  Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction.  Marine Drugs,  21  (10): (502).  [PMID:37888437] [10.3390/md21100502]
4. Xueqin Wang, Zhenzhen Cui, Yuan Luo, Yu Huang, Xinbin Yang.  (2023)  In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3′-sulfonate.  FOOD AND CHEMICAL TOXICOLOGY,  177  (113854).  [PMID:37230458] [10.1016/j.fct.2023.113854]
5. Jiling Song, Minghui Chen, Fanlei Meng, Jiahui Chen, Zhanwei Wang, Yong Zhang, Jing Cui, Jing Wang, Dongfang Shi.  (2023)  Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  299  (122861).  [PMID:37209475] [10.1016/j.saa.2023.122861]
6. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin.  (2023)  Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies.  IET Nanobiotechnology,  17  (4): (368-375).  [PMID:37153957] [10.1049/nbt2.12135]
7. Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi, Ying-Hua Zhang.  (2023)  Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein.  FOOD RESEARCH INTERNATIONAL,  169  (112882).  [PMID:37254330] [10.1016/j.foodres.2023.112882]
8. Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang.  (2023)  In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  232  (115415).  [PMID:37120975] [10.1016/j.jpba.2023.115415]
9. Jiling Song, Zhanwei Wang, Yu Chi, Yong Zhang, Chenyi Fang, Yuting Shu, Jing Cui, Helong Bai, Jing Wang.  (2023)  Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase.  BIOORGANIC CHEMISTRY,  133  (106394).  [PMID:36801789] [10.1016/j.bioorg.2023.106394]
10. Yingling Sui, Deping Xu, Xiulan Sun.  (2023)  Identification of anti-hyperuricemic components from Coix seed.  Food Bioscience,  52  (102461).  [PMID:] [10.1016/j.fbio.2023.102461]
11. Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich.  (2023)  Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels.  Biomaterials Science,  11  (5): (1704-1713).  [PMID:36628631] [10.1039/D2BM01836E]
12. Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian, Guiming Fu.  (2022)  Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz.  Food & Function,  13  (22): (11780-11793).  [PMID:36300542] [10.1039/D2FO01854C]
13. Gao Tianshu, Xu Jin, Xiao Yuxiao, Li Jiaqi, Hu Weifeng, Su Xiaoyu, Shen Xudong, Yu Wan, Chen Zhen, Huang Baosheng, Li Honglei, Wang Xing.  (2022)  Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.  Frontiers in Pharmacology,  13    [PMID:36120294] [10.3389/fphar.2022.950699]
14. Yawen Lian, Xiang Yuan, Yandan Wang, Lin Wei.  (2022)  Highly sensitive visual colorimetric sensor for xanthine oxidase detection by using MnO2-nanosheet-modified gold nanoparticles.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  276  (121219).  [PMID:35397450] [10.1016/j.saa.2022.121219]
15. Rui Sun, Juan Kan, Huahao Cai, Jinhai Hong, Changhai Jin, Man Zhang.  (2022)  In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  46  (2): (e14049).  [PMID:34981522] [10.1111/jfbc.14049]
16. Liyan Yuan, Zhijie Bao, Tiecheng Ma, Songyi Lin.  (2021)  Hypouricemia effects of corn silk flavonoids in a mouse model of potassium oxonated-induced hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  45  (8): (e13856).  [PMID:34250618] [10.1111/jfbc.13856]
17. Yin Wan, Jin Qian, Yizhen Li, Yuefeng Shen, Yanru Chen, Guiming Fu, Mingyong Xie.  (2021)  Inhibitory mechanism of xanthine oxidase activity by caffeoylquinic acids in vitro.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  184  (843).  [PMID:34146563] [10.1016/j.ijbiomac.2021.06.075]
18. Caixin Ni, Xin Li, Linlin Wang, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen.  (2021)  Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism.  Food & Function,  12  (15): (7054-7067).  [PMID:34152353] [10.1039/D1FO00198A]
19. Shi Feng, Chen Lin, Wang Yaping, Liu Jing, Adu-Frimpong Michael, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing.  (2022)  Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system.  Drug Delivery and Translational Research,  12  (3): (603-614).  [PMID:33860450] [10.1007/s13346-021-00969-8]
20. Xie Jiahong, Cui Haoxin, Xu Yang, Xie Lianghua, Chen Wei.  (2021)  Delphinidin-3-O-sambubioside: a novel xanthine oxidase inhibitor identified from natural anthocyanins.  Food Quality and Safety,    [PMID:] [10.1093/fqsafe/fyaa038]
21. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259] [10.1039/D0FO03059G]
22. Yanzuo Le, Xie Zhou, Jiawen Zheng, Fangmiao Yu, Yunping Tang, Zuisu Yang, Guofang Ding, Yan Chen.  (2020)  Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats.  Marine Drugs,  18  (12): (610).  [PMID:33271765] [10.3390/md18120610]
23. Yi Tao, Lin Chen, Enci Jiang.  (2021)  Layer-by-layer assembly strategy for fabrication of polydopamine-polyethyleneimine hybrid modified fibers and their application to solid-phase microextraction of bioactive molecules from medicinal plant samples followed by surface plasmon resonance biosensor validation.  ANALYTICA CHIMICA ACTA,  1146  (155).  [PMID:33461711] [10.1016/j.aca.2020.11.016]
24. Xingchu Gong, Jingyuan Shao, Shangxin Guo, Jingjing Pan, Xiaohui Fan.  (2021)  Determination of inhibitory activity of Salvia miltiorrhiza extracts on xanthine oxidase with a paper-based analytical device.  Journal of Pharmaceutical Analysis,  11  (603).  [PMID:34765273] [10.1016/j.jpha.2020.09.004]
25. Xiao-Wei Zhang, Mei Zhou, Lin An, Ping Zhang, Ping Li, Jun Chen.  (2020)  Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways.  AMERICAN JOURNAL OF CHINESE MEDICINE,  48  (6): (1455-1473).  [PMID:32933312] [10.1142/S0192415X20500718]
26. Wen Weng, Qilong Wang, Chunmei Wei, Na Man, Kangyi Zhang, Qiuyu Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu.  (2019)  Preparation, characterization, pharmacokinetics and anti-hyperuricemia activity studies of myricitrin-loaded proliposomes.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  572  (118735).  [PMID:31705971] [10.1016/j.ijpharm.2019.118735]
27. Zhang Kangyi, Wang Qilong, Yang Qiuxuan, Wei Qiuyu, Man Na, Adu-Frimpong Michael, Toreniyazov Elmurat, Ji Hao, Yu Jiangnan, Xu Ximing.  (2019)  Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System.  AAPS PHARMSCITECH,  20  (5): (1-11).  [PMID:31187334] [10.1208/s12249-019-1421-0]
28. Yin Wan, Fen Wang, Bin Zou, Yuefeng Shen, Yizhen Li, Axi Zhang, Guiming Fu.  (2019)  Molecular mechanism underlying the ability of caffeic acid to decrease uric acid levels in hyperuricemia rats.  Journal of Functional Foods,  57  (150).  [PMID:] [10.1016/j.jff.2019.03.038]
29. Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Huiping Hu, Dan Zuo, Danling Liang.  (2018)  Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.  AMERICAN JOURNAL OF CHINESE MEDICINE,  46  (3): (585-599).  [PMID:29595077] [10.1142/S0192415X18500301]
30. Yin Wan, Yu-Xi Liang, Bin Zou, Gui-Ming Fu, Ming-Yong Xie.  (2018)  The possible mechanism of hydroxytyrosol on reducing uric acid levels.  Journal of Functional Foods,  42  (319).  [PMID:] [10.1016/j.jff.2018.01.009]
31. Jing Wang, Dongfang Shi, Meizhu Zheng, Bing Ma, Jing Cui, Chunming Liu, Chengyu Liu.  (2017)  Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.  JOURNAL OF SEPARATION SCIENCE,  40  (21): (4160-4167).  [PMID:28857450] [10.1002/jssc.201700690]
32. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan.  (2017)  Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.  JOURNAL OF FOOD BIOCHEMISTRY,  41  (4): (e12377).  [PMID:] [10.1111/jfbc.12377]
33. Hongjin Tang, Lin Yang, Wei Li, Jiahuang Li, Jun Chen.  (2016)  Exploring the interaction between Salvia miltiorrhiza and xanthine oxidase: insights from computational analysis and experimental studies combined with enzyme channel blocking.  RSC Advances,  (114): (113527-113537).  [PMID:] [10.1039/C6RA24396G]
34. Yin Wan, Bin Zou, Hailong Zeng, Lunning Zhang, Ming Chen, Guiming Fu.  (2016)  Inhibitory effect of verbascoside on xanthine oxidase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  93  (609).  [PMID:27616694] [10.1016/j.ijbiomac.2016.09.022]
35. Fu Yu, Mo Hua-Yan, Gao Wen, Hong Jia-Ying, Lu Jun, Li Ping, Chen Jun.  (2014)  Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  406  (20): (4987-4995).  [PMID:24866714] [10.1007/s00216-014-7902-9]

References

1. Pini M et al..  (2021)  Adipose tissue senescence is mediated by increased ATP content after a short-term high-fat diet exposure..  Aging Cell,  20  (8): (e13421).  [PMID:34278707]
2. Jiana Du, Na Wang, Dehong Yu, Pei He, Yu Gao, Yanbei Tu, Yanfang Li.  (2023)  Data mining-guided alleviation of hyperuricemia by Paeonia veitchii Lynch through inhibition of xanthine oxidase and regulation of renal urate transporters.  PHYTOMEDICINE,    (155305).  [PMID:38176275] [10.1016/j.phymed.2023.155305]
3. Jie Xiong, Ya-ying Wang, Muhammad Yousaf, Dong-mei Liu.  (2023)  Improvement of Physicochemical Properties and Flavor of Pickled Radish through the Use of a Direct-Vat Set Starter Consisting of Lactiplantibacillus Plantarum and Leuconostoc Mesenteroides.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,      [PMID:21153684] [10.1111/ijfs.16731]
4. Yawen Wang, Longjian Zhou, Minqi Chen, Yayue Liu, Yu Yang, Tiantian Lu, Fangfang Ban, Xueqiong Hu, Zhongji Qian, Pengzhi Hong, Yi Zhang.  (2023)  Mining Xanthine Oxidase Inhibitors from an Edible Seaweed Pterocladiella capillacea by Using In Vitro Bioassays, Affinity Ultrafiltration LC-MS/MS, Metabolomics Tools, and In Silico Prediction.  Marine Drugs,  21  (10): (502).  [PMID:37888437] [10.3390/md21100502]
5. Xueqin Wang, Zhenzhen Cui, Yuan Luo, Yu Huang, Xinbin Yang.  (2023)  In vitro xanthine oxidase inhibitory and in vivo anti-hyperuricemic properties of sodium kaempferol-3′-sulfonate.  FOOD AND CHEMICAL TOXICOLOGY,  177  (113854).  [PMID:37230458] [10.1016/j.fct.2023.113854]
6. Jiling Song, Minghui Chen, Fanlei Meng, Jiahui Chen, Zhanwei Wang, Yong Zhang, Jing Cui, Jing Wang, Dongfang Shi.  (2023)  Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  299  (122861).  [PMID:37209475] [10.1016/j.saa.2023.122861]
7. Jianmin Chen, Zemin He, Sijin Yu, Xiaozhen Cai, Danhong Zhu, Yanhua Lin.  (2023)  Xanthine oxidase inhibitory kinetics and mechanism of ellagic acid: In vitro, in silico and in vivo studies.  IET Nanobiotechnology,  17  (4): (368-375).  [PMID:37153957] [10.1049/nbt2.12135]
8. Yi-Fang Gao, Meng-Qi Liu, Zhong-Han Li, Han-Lin Zhang, Jia-Qi Hao, Bo-Hao Liu, Xiao-Yan Li, Yu-Qi Yin, Xiao-Hui Wang, Qian Zhou, Di Xu, Bao-Ming Shi, Ying-Hua Zhang.  (2023)  Purification and identification of xanthine oxidase inhibitory peptides from enzymatic hydrolysate of α-lactalbumin and bovine colostrum casein.  FOOD RESEARCH INTERNATIONAL,  169  (112882).  [PMID:37254330] [10.1016/j.foodres.2023.112882]
9. Jinhua Li, Namrta Choudhry, Gang Lv, Naganna Nimishetti, Mallu Chenna Reddy, Hong Liu, Thaddeus D. Allen, Jing Zhang, Dun Yang.  (2023)  In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,  232  (115415).  [PMID:37120975] [10.1016/j.jpba.2023.115415]
10. Jiling Song, Zhanwei Wang, Yu Chi, Yong Zhang, Chenyi Fang, Yuting Shu, Jing Cui, Helong Bai, Jing Wang.  (2023)  Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase.  BIOORGANIC CHEMISTRY,  133  (106394).  [PMID:36801789] [10.1016/j.bioorg.2023.106394]
11. Yingling Sui, Deping Xu, Xiulan Sun.  (2023)  Identification of anti-hyperuricemic components from Coix seed.  Food Bioscience,  52  (102461).  [PMID:] [10.1016/j.fbio.2023.102461]
12. Rui Wang, Han Wang, Guohua Jiang, Yanfang Sun, Tianqi Liu, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Uladzislau E. Aharodnikau, Sergey O. Solomevich.  (2023)  Transdermal delivery of allopurinol to acute hyperuricemic mice via polymer microneedles for the regulation of serum uric acid levels.  Biomaterials Science,  11  (5): (1704-1713).  [PMID:36628631] [10.1039/D2BM01836E]
13. Yin Wan, Dengxiao Wang, Yuefeng Shen, Yanru Chen, Jin Qian, Guiming Fu.  (2022)  Effect of Lactobacillus acidophilus fermentation on the composition of chlorogenic acids and anti-hyperuricemia activity of Artemisia selengensis Turcz.  Food & Function,  13  (22): (11780-11793).  [PMID:36300542] [10.1039/D2FO01854C]
14. Gao Tianshu, Xu Jin, Xiao Yuxiao, Li Jiaqi, Hu Weifeng, Su Xiaoyu, Shen Xudong, Yu Wan, Chen Zhen, Huang Baosheng, Li Honglei, Wang Xing.  (2022)  Therapeutic effects and mechanisms of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors on hyperuricemia.  Frontiers in Pharmacology,  13    [PMID:36120294] [10.3389/fphar.2022.950699]
15. Yawen Lian, Xiang Yuan, Yandan Wang, Lin Wei.  (2022)  Highly sensitive visual colorimetric sensor for xanthine oxidase detection by using MnO2-nanosheet-modified gold nanoparticles.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,  276  (121219).  [PMID:35397450] [10.1016/j.saa.2022.121219]
16. Rui Sun, Juan Kan, Huahao Cai, Jinhai Hong, Changhai Jin, Man Zhang.  (2022)  In vitro and in vivo ameliorative effects of polyphenols from purple potato leaves on renal injury and associated inflammation induced by hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  46  (2): (e14049).  [PMID:34981522] [10.1111/jfbc.14049]
17. Liyan Yuan, Zhijie Bao, Tiecheng Ma, Songyi Lin.  (2021)  Hypouricemia effects of corn silk flavonoids in a mouse model of potassium oxonated-induced hyperuricemia.  JOURNAL OF FOOD BIOCHEMISTRY,  45  (8): (e13856).  [PMID:34250618] [10.1111/jfbc.13856]
18. Yin Wan, Jin Qian, Yizhen Li, Yuefeng Shen, Yanru Chen, Guiming Fu, Mingyong Xie.  (2021)  Inhibitory mechanism of xanthine oxidase activity by caffeoylquinic acids in vitro.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  184  (843).  [PMID:34146563] [10.1016/j.ijbiomac.2021.06.075]
19. Caixin Ni, Xin Li, Linlin Wang, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen.  (2021)  Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism.  Food & Function,  12  (15): (7054-7067).  [PMID:34152353] [10.1039/D1FO00198A]
20. Shi Feng, Chen Lin, Wang Yaping, Liu Jing, Adu-Frimpong Michael, Ji Hao, Toreniyazov Elmurat, Wang Qilong, Yu Jiangnan, Xu Ximing.  (2022)  Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®—glycyrrhizic acid mixed micelle system.  Drug Delivery and Translational Research,  12  (3): (603-614).  [PMID:33860450] [10.1007/s13346-021-00969-8]
21. Xie Jiahong, Cui Haoxin, Xu Yang, Xie Lianghua, Chen Wei.  (2021)  Delphinidin-3-O-sambubioside: a novel xanthine oxidase inhibitor identified from natural anthocyanins.  Food Quality and Safety,    [PMID:] [10.1093/fqsafe/fyaa038]
22. Qian Zhou, Jia-Yi Yin, Wei-Yue Liang, Dong-Mei Chen, Qing Yuan, Bao-long Feng, Ying-Hua Zhang, Yu-Tang Wang.  (2021)  Various machine learning approaches coupled with molecule simulation in the screening of natural compounds with xanthine oxidase inhibitory activity.  Food & Function,  12  (4): (1580-1589).  [PMID:33470259] [10.1039/D0FO03059G]
23. Yanzuo Le, Xie Zhou, Jiawen Zheng, Fangmiao Yu, Yunping Tang, Zuisu Yang, Guofang Ding, Yan Chen.  (2020)  Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in Rats.  Marine Drugs,  18  (12): (610).  [PMID:33271765] [10.3390/md18120610]
24. Yi Tao, Lin Chen, Enci Jiang.  (2021)  Layer-by-layer assembly strategy for fabrication of polydopamine-polyethyleneimine hybrid modified fibers and their application to solid-phase microextraction of bioactive molecules from medicinal plant samples followed by surface plasmon resonance biosensor validation.  ANALYTICA CHIMICA ACTA,  1146  (155).  [PMID:33461711] [10.1016/j.aca.2020.11.016]
25. Xingchu Gong, Jingyuan Shao, Shangxin Guo, Jingjing Pan, Xiaohui Fan.  (2021)  Determination of inhibitory activity of Salvia miltiorrhiza extracts on xanthine oxidase with a paper-based analytical device.  Journal of Pharmaceutical Analysis,  11  (603).  [PMID:34765273] [10.1016/j.jpha.2020.09.004]
26. Xiao-Wei Zhang, Mei Zhou, Lin An, Ping Zhang, Ping Li, Jun Chen.  (2020)  Lipophilic Extract and Tanshinone IIA Derived from Salvia miltiorrhiza Attenuate Uric Acid Nephropathy through Suppressing Oxidative Stress-Activated MAPK Pathways.  AMERICAN JOURNAL OF CHINESE MEDICINE,  48  (6): (1455-1473).  [PMID:32933312] [10.1142/S0192415X20500718]
27. Wen Weng, Qilong Wang, Chunmei Wei, Na Man, Kangyi Zhang, Qiuyu Wei, Michael Adu-Frimpong, Elmurat Toreniyazov, Hao Ji, Jiangnan Yu, Ximing Xu.  (2019)  Preparation, characterization, pharmacokinetics and anti-hyperuricemia activity studies of myricitrin-loaded proliposomes.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  572  (118735).  [PMID:31705971] [10.1016/j.ijpharm.2019.118735]
28. Zhang Kangyi, Wang Qilong, Yang Qiuxuan, Wei Qiuyu, Man Na, Adu-Frimpong Michael, Toreniyazov Elmurat, Ji Hao, Yu Jiangnan, Xu Ximing.  (2019)  Enhancement of Oral Bioavailability and Anti-hyperuricemic Activity of Isoliquiritigenin via Self-Microemulsifying Drug Delivery System.  AAPS PHARMSCITECH,  20  (5): (1-11).  [PMID:31187334] [10.1208/s12249-019-1421-0]
29. Yin Wan, Fen Wang, Bin Zou, Yuefeng Shen, Yizhen Li, Axi Zhang, Guiming Fu.  (2019)  Molecular mechanism underlying the ability of caffeic acid to decrease uric acid levels in hyperuricemia rats.  Journal of Functional Foods,  57  (150).  [PMID:] [10.1016/j.jff.2019.03.038]
30. Tianqiao Yong, Shaodan Chen, Yizhen Xie, Diling Chen, Jiyan Su, Ou Shuai, Huiping Hu, Dan Zuo, Danling Liang.  (2018)  Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.  AMERICAN JOURNAL OF CHINESE MEDICINE,  46  (3): (585-599).  [PMID:29595077] [10.1142/S0192415X18500301]
31. Yin Wan, Yu-Xi Liang, Bin Zou, Gui-Ming Fu, Ming-Yong Xie.  (2018)  The possible mechanism of hydroxytyrosol on reducing uric acid levels.  Journal of Functional Foods,  42  (319).  [PMID:] [10.1016/j.jff.2018.01.009]
32. Jing Wang, Dongfang Shi, Meizhu Zheng, Bing Ma, Jing Cui, Chunming Liu, Chengyu Liu.  (2017)  Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.  JOURNAL OF SEPARATION SCIENCE,  40  (21): (4160-4167).  [PMID:28857450] [10.1002/jssc.201700690]
33. Zeynep Tohtahon, Lu Zhang, Jianxin Han, Xing Xie, Zongcai Tu, Tao Yuan.  (2017)  Extraction optimization, structural characterization and bioactivity evaluation of triterpenoids from hawthorn (Crataegus cuneata) fruits.  JOURNAL OF FOOD BIOCHEMISTRY,  41  (4): (e12377).  [PMID:] [10.1111/jfbc.12377]
34. Hongjin Tang, Lin Yang, Wei Li, Jiahuang Li, Jun Chen.  (2016)  Exploring the interaction between Salvia miltiorrhiza and xanthine oxidase: insights from computational analysis and experimental studies combined with enzyme channel blocking.  RSC Advances,  (114): (113527-113537).  [PMID:] [10.1039/C6RA24396G]
35. Yin Wan, Bin Zou, Hailong Zeng, Lunning Zhang, Ming Chen, Guiming Fu.  (2016)  Inhibitory effect of verbascoside on xanthine oxidase activity.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  93  (609).  [PMID:27616694] [10.1016/j.ijbiomac.2016.09.022]
36. Fu Yu, Mo Hua-Yan, Gao Wen, Hong Jia-Ying, Lu Jun, Li Ping, Chen Jun.  (2014)  Affinity selection-based two-dimensional chromatography coupled with high-performance liquid chromatography-mass spectrometry for discovering xanthine oxidase inhibitors from Radix Salviae Miltiorrhizae.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  406  (20): (4987-4995).  [PMID:24866714] [10.1007/s00216-014-7902-9]

Solution Calculators