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AGC:Containing PKA, PKG, PKC families
allosteric modulator 33 , CAS No.A607511, Allosteric modulator of Protein kinase G (PKG) 1

allosteric modulator 33 , CAS No.A607511, Allosteric modulator of Protein kinase G (PKG) 1

Item Number

A607511

Grouped product items
SKU	Size	Availability	Price	Qty
A607511-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607511-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

Synonyms	compound 33
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR
Mechanism of action	Allosteric modulator of Protein kinase G (PKG) 1

PRKG1 Tchem cGMP-dependent protein kinase 1 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKG1 Tchem cGMP-dependent protein kinase 1 beta (2814 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	4-(((2S,3S)-3-((S)-1-(3,5-Dichlorophenyl)-2-hydroxyethoxy)-2-phenylpiperidin-1-yl)methyl)-3-nitrobenzoic Acid
INCHI	InChI=1S/C27H26Cl2N2O6/c28-21-11-20(12-22(29)14-21)25(16-32)37-24-7-4-10-30(26(24)17-5-2-1-3-6-17)15-19-9-8-18(27(33)34)13-23(19)31(35)36/h1-3,5-6,8-9,11-14,24-26,32H,4,7,10,15-16H2,(H,33,34)/t24-,25+,26-/m0/s1
InChi Key	REDPQDQMPNUDEP-NXCFDTQHSA-N
Canonical SMILES	OC[C@H](c1cc(Cl)cc(Cl)c1)O[C@@H]1[C@H](c2ccccc2)N(Cc2c([N+](=O)[O-])cc(C(=O)O)cc2)CCC1
Isomeric SMILES	C1C[C@@H]([C@@H](N(C1)CC2=C(C=C(C=C2)C(=O)O)[N+](=O)[O-])C3=CC=CC=C3)O[C@H](CO)C4=CC(=CC(=C4)Cl)Cl
PubChem CID	164885943

RCSB PDB Ligand	B4I, B4I
PubChem CID	164885943

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1. Mak VW, Patel AM, Yen R, Hanisak J, Lim YH, Bao J, Zheng R, Seganish WM, Yu Y, Healy DR et al.. (2022) Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α.. J Med Chem, 129 (3): (589-97). [PMID:35878399]

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