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Aloe-emodin - 95%, high purity , CAS No.481-72-1

  • ≥95%
Item Number
A111278
Grouped product items
SKUSizeAvailabilityPrice Qty
A111278-25mg
25mg
In stock
$43.90
A111278-100mg
100mg
In stock
$133.90
A111278-250mg
250mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$161.90
A111278-500mg
500mg
In stock
$293.90
A111278-1g
1g
In stock
$532.90
A111278-5g
5g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,394.90
A111278-25g
25g
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$10,773.90

Apoptotic and anticancer agent

Basic Description

SynonymsAloe-emodin|Aloe emodin|481-72-1|Aloeemodin|Rhabarberone|Aloe-emodine|3-Hydroxymethylchrysazine|1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione|3-Hydroxymethylchrysazin|EMODINE|1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone|1,8-Dihydroxy-3-hydroxymethy
Specifications & Purity≥95%
Biochemical and Physiological MechanismsLaxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondr
Storage TempStore at 2-8°C
Shipped InWet ice
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

ESR1 Tclin Estrogen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ELANE Tclin Neutrophil elastase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CTSG Tchem Cathepsin G 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CELA2A Tbio Chymotrypsin-like elastase family member 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

EPHX2 Tchem Bifunctional epoxide hydrolase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FUCA1 Tchem Tissue alpha-L-fucosidase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FEN1 Tchem Flap endonuclease 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD2 Tbio Thioredoxin reductase 2, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TTR Tclin Transthyretin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PIN1 Tchem Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

XDH Tclin Xanthine dehydrogenase/oxidase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ACHE Tclin Acetylcholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOB Tclin Amine oxidase [flavin-containing] B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BCHE Tclin Cholinesterase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KPNB1 Tbio Importin subunit beta-1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

P2RY12 Tclin P2Y purinoceptor 12 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALPI Tchem Intestinal-type alkaline phosphatase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALPL Tchem Alkaline phosphatase, tissue-nonspecific isozyme 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALPG Tchem Alkaline phosphatase, germ cell type 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488181089
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488181089
IUPAC Name 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
INCHI InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
InChi Key YDQWDHRMZQUTBA-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Isomeric SMILES C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
WGK Germany 3
RTECS CB6712200
PubChem CID 10207
Molecular Weight 270.24
Beilstein 2059062

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

16 results found

Lot NumberCertificate TypeDateItem
D2424088Certificate of AnalysisMar 09, 2024 A111278
D2424089Certificate of AnalysisMar 09, 2024 A111278
B2420036Certificate of AnalysisFeb 27, 2024 A111278
H2401015Certificate of AnalysisFeb 27, 2024 A111278
J2211616Certificate of AnalysisMay 25, 2023 A111278
J2211620Certificate of AnalysisMay 25, 2023 A111278
J2211634Certificate of AnalysisMay 25, 2023 A111278
J2211659Certificate of AnalysisMay 25, 2023 A111278
J2211676Certificate of AnalysisMay 25, 2023 A111278
E1921029Certificate of AnalysisMar 08, 2023 A111278
B2325258Certificate of AnalysisMar 02, 2023 A111278
B2325259Certificate of AnalysisMar 02, 2023 A111278
K1826043Certificate of AnalysisSep 16, 2022 A111278
J1819038Certificate of AnalysisAug 10, 2022 A111278
B2325257Certificate of AnalysisNov 17, 2021 A111278
K2110548Certificate of AnalysisNov 17, 2021 A111278

more

Chemical and Physical Properties

SensitivityHeat sensitive.
Melt Point(°C)223-224°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS CB6712200
Merck Index 306

Related Documents

References

1. Baqi Y, Atzler K, Köse M, Glänzel M, Müller CE.  (2009)  High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors..  J Med Chem,  52  (12): (3784-93).  [PMID:19463000]
2. Tom Coenye,Kris Honraet,Petra Rigole,Pol Nadal Jimenez,Hans J Nelis.  (2007-01-16)  In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones..  Antimicrobial agents and chemotherapy,  51  ((4)): (1541-1544).  [PMID:17220400]
3. Xing-Ri Cui,Maiko Tsukada,Nao Suzuki,Takeshi Shimamura,Li Gao,Jyunichi Koyanagi,Fusao Komada,Setsuo Saito.  (2007-10-24)  Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones..  European journal of medicinal chemistry,  43  ((6)): (1206-1215).  [PMID:17949858]
4. Junko Koyama,Yu Nisino,Izumi Morita,Norihiro Kobayashi,Toshiyuki Osakai,Harukuni Tokuda.  (2008-06-17)  Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives..  Bioorganic & medicinal chemistry letters,  18  ((14)): (4106-4109).  [PMID:18556196]
5. Francesca Sorrentino,Anastasia Karioti,Paola Gratteri,Maria Pia Rigobello,Guido Scutari,Luigi Messori,Alberto Bindoli,Matteo Chioccioli,Chiara Gabbiani,Maria Camilla Bergonzi,Anna Rita Bilia.  (2010-11-26)  Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones..  Bioorganic & medicinal chemistry,  19  ((1)): (631-641).  [PMID:21106380]
6. Khalilah Haris,Samhani Ismail,Zamzuri Idris,Jafri Malin Abdullah,Abdul Aziz Mohamed Yusoff.  (2014-06-28)  Expression profile of genes modulated by Aloe emodin in human U87 glioblastoma cells..  Asian Pacific journal of cancer prevention : APJCP,  15  ((11)): (4499-4505).  [PMID:24969876]
7. Naraganahalli R Thimmegowda,Chanmi Park,Bettaswamigowda Shwetha,Krisada Sakchaisri,Kangdong Liu,Joonsung Hwang,Sangku Lee,Sook J Jeong,Nak K Soung,Jae H Jang,In-Ja Ryoo,Jong S Ahn,Raymond L Erikson,Bo Y Kim.  (2014-10-18)  Synthesis and antitumor activity of natural compound aloe emodin derivatives..  Chemical biology & drug design,  85  ((5)): (638-644).  [PMID:25323822]
8. Mildred Acevedo-Duncan,Christopher Russell,Sapna Patel,Rekha Patel.  (2004-11-09)  Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells..  International immunopharmacology,  ((14)): (1775-1784).  [PMID:15531293]
9. Xia Zhou,Baoan Song,Linhong Jin,Deyu Hu,Chunling Diao,Guangfang Xu,Zhihui Zou,Song Yang.  (2005-11-09)  Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb..  Bioorganic & medicinal chemistry letters,  16  ((3)): (563-568).  [PMID:16275083]
10. Jun-ming Guo,Bing-xiu Xiao,Qiong Liu,Shun Zhang,Dong-hai Liu,Zhao-hui Gong.  (2007-11-23)  Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation..  Acta pharmacologica Sinica,  28  ((12)): (1991-1995).  [PMID:18031614]
11. Yiqun Du,Jian Zhang,Zhonghua Tao,Chenchen Wang,Shiyan Yan,Xiaowei Zhang,Mingzhu Huang.  (2019-05-28)  Aloe emodin exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential (ΛΨm)..  Journal of B.U.ON. : official journal of the Balkan Union of Oncology,  24  ((2)): (746-753).  [PMID:31128032]

Solution Calculators