Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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A111278-25mg | 25mg | In stock | $43.90 | |
A111278-100mg | 100mg | In stock | $133.90 | |
A111278-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $161.90 | |
A111278-500mg | 500mg | In stock | $293.90 | |
A111278-1g | 1g | In stock | $532.90 | |
A111278-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,394.90 | |
A111278-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $10,773.90 |
Apoptotic and anticancer agent
Synonyms | Aloe-emodin|Aloe emodin|481-72-1|Aloeemodin|Rhabarberone|Aloe-emodine|3-Hydroxymethylchrysazine|1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione|3-Hydroxymethylchrysazin|EMODINE|1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone|1,8-Dihydroxy-3-hydroxymethy |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondr |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Pubchem Sid | 488181089 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488181089 |
IUPAC Name | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione |
INCHI | InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 |
InChi Key | YDQWDHRMZQUTBA-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO |
Isomeric SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO |
WGK Germany | 3 |
RTECS | CB6712200 |
PubChem CID | 10207 |
Molecular Weight | 270.24 |
Beilstein | 2059062 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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D2424088 | Certificate of Analysis | Mar 09, 2024 | A111278 |
D2424089 | Certificate of Analysis | Mar 09, 2024 | A111278 |
B2420036 | Certificate of Analysis | Feb 27, 2024 | A111278 |
H2401015 | Certificate of Analysis | Feb 27, 2024 | A111278 |
J2211616 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211620 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211634 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211659 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211676 | Certificate of Analysis | May 25, 2023 | A111278 |
E1921029 | Certificate of Analysis | Mar 08, 2023 | A111278 |
B2325258 | Certificate of Analysis | Mar 02, 2023 | A111278 |
B2325259 | Certificate of Analysis | Mar 02, 2023 | A111278 |
K1826043 | Certificate of Analysis | Sep 16, 2022 | A111278 |
J1819038 | Certificate of Analysis | Aug 10, 2022 | A111278 |
B2325257 | Certificate of Analysis | Nov 17, 2021 | A111278 |
K2110548 | Certificate of Analysis | Nov 17, 2021 | A111278 |
Sensitivity | Heat sensitive. |
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Melt Point(°C) | 223-224°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | CB6712200 |
Merck Index | 306 |
1. Baqi Y, Atzler K, Köse M, Glänzel M, Müller CE. (2009) High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.. J Med Chem, 52 (12): (3784-93). [PMID:19463000] |
2. Tom Coenye,Kris Honraet,Petra Rigole,Pol Nadal Jimenez,Hans J Nelis. (2007-01-16) In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.. Antimicrobial agents and chemotherapy, 51 ((4)): (1541-1544). [PMID:17220400] |
3. Xing-Ri Cui,Maiko Tsukada,Nao Suzuki,Takeshi Shimamura,Li Gao,Jyunichi Koyanagi,Fusao Komada,Setsuo Saito. (2007-10-24) Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.. European journal of medicinal chemistry, 43 ((6)): (1206-1215). [PMID:17949858] |
4. Junko Koyama,Yu Nisino,Izumi Morita,Norihiro Kobayashi,Toshiyuki Osakai,Harukuni Tokuda. (2008-06-17) Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.. Bioorganic & medicinal chemistry letters, 18 ((14)): (4106-4109). [PMID:18556196] |
5. Francesca Sorrentino,Anastasia Karioti,Paola Gratteri,Maria Pia Rigobello,Guido Scutari,Luigi Messori,Alberto Bindoli,Matteo Chioccioli,Chiara Gabbiani,Maria Camilla Bergonzi,Anna Rita Bilia. (2010-11-26) Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.. Bioorganic & medicinal chemistry, 19 ((1)): (631-641). [PMID:21106380] |
6. Khalilah Haris,Samhani Ismail,Zamzuri Idris,Jafri Malin Abdullah,Abdul Aziz Mohamed Yusoff. (2014-06-28) Expression profile of genes modulated by Aloe emodin in human U87 glioblastoma cells.. Asian Pacific journal of cancer prevention : APJCP, 15 ((11)): (4499-4505). [PMID:24969876] |
7. Naraganahalli R Thimmegowda,Chanmi Park,Bettaswamigowda Shwetha,Krisada Sakchaisri,Kangdong Liu,Joonsung Hwang,Sangku Lee,Sook J Jeong,Nak K Soung,Jae H Jang,In-Ja Ryoo,Jong S Ahn,Raymond L Erikson,Bo Y Kim. (2014-10-18) Synthesis and antitumor activity of natural compound aloe emodin derivatives.. Chemical biology & drug design, 85 ((5)): (638-644). [PMID:25323822] |
8. Mildred Acevedo-Duncan,Christopher Russell,Sapna Patel,Rekha Patel. (2004-11-09) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.. International immunopharmacology, 4 ((14)): (1775-1784). [PMID:15531293] |
9. Xia Zhou,Baoan Song,Linhong Jin,Deyu Hu,Chunling Diao,Guangfang Xu,Zhihui Zou,Song Yang. (2005-11-09) Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb.. Bioorganic & medicinal chemistry letters, 16 ((3)): (563-568). [PMID:16275083] |
10. Jun-ming Guo,Bing-xiu Xiao,Qiong Liu,Shun Zhang,Dong-hai Liu,Zhao-hui Gong. (2007-11-23) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation.. Acta pharmacologica Sinica, 28 ((12)): (1991-1995). [PMID:18031614] |
11. Yiqun Du,Jian Zhang,Zhonghua Tao,Chenchen Wang,Shiyan Yan,Xiaowei Zhang,Mingzhu Huang. (2019-05-28) Aloe emodin exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential (ΛΨm).. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 24 ((2)): (746-753). [PMID:31128032] |