Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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A111278-25mg | 25mg | In stock | $43.90 | |
A111278-100mg | 100mg | In stock | $133.90 | |
A111278-250mg | 250mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $161.90 | |
A111278-500mg | 500mg | In stock | $293.90 | |
A111278-1g | 1g | In stock | $532.90 | |
A111278-5g | 5g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,394.90 | |
A111278-25g | 25g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $10,773.90 |
Apoptotic and anticancer agent
Synonyms | 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)- | Aloeemodin | Aloe-emodin | Aloe-emodin, analytical standard | Q-100526 | MLS000697563 | s2259 | CCG-208456 | SR-01000765772-3 | 3-(Hydroxymethyl)chrysazin | 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-h |
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Specifications & Purity | ≥95% |
Biochemical and Physiological Mechanisms | Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondr |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488181089 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488181089 |
IUPAC Name | 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione |
INCHI | InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2 |
InChi Key | YDQWDHRMZQUTBA-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO |
Isomeric SMILES | C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO |
WGK Germany | 3 |
RTECS | CB6712200 |
PubChem CID | 10207 |
Molecular Weight | 270.24 |
Beilstein | 2059062 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
K2414100 | Certificate of Analysis | Nov 19, 2024 | A111278 |
D2424088 | Certificate of Analysis | Mar 09, 2024 | A111278 |
D2424089 | Certificate of Analysis | Mar 09, 2024 | A111278 |
B2420036 | Certificate of Analysis | Feb 27, 2024 | A111278 |
H2401015 | Certificate of Analysis | Feb 27, 2024 | A111278 |
J2211676 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211659 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211616 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211620 | Certificate of Analysis | May 25, 2023 | A111278 |
J2211634 | Certificate of Analysis | May 25, 2023 | A111278 |
E1921029 | Certificate of Analysis | Mar 08, 2023 | A111278 |
B2325258 | Certificate of Analysis | Mar 02, 2023 | A111278 |
B2325259 | Certificate of Analysis | Mar 02, 2023 | A111278 |
K1826043 | Certificate of Analysis | Sep 16, 2022 | A111278 |
J1819038 | Certificate of Analysis | Aug 10, 2022 | A111278 |
K2110548 | Certificate of Analysis | Nov 17, 2021 | A111278 |
B2325257 | Certificate of Analysis | Nov 17, 2021 | A111278 |
Sensitivity | Heat sensitive. |
---|---|
Melt Point(°C) | 223-224°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | CB6712200 |
Merck Index | 306 |
1. Wenbin Chen, Airi N. Kato, Lijun Dai, Paul S. Clegg, Tao Li. (2023) Continuous Emulsion Channels Achieved by Controlling the Aqueous–Oil Interface Solely with Rough Colloids. ADVANCED FUNCTIONAL MATERIALS, 34 (6): (2308608). [PMID:9647693] [10.1002/adfm.202308608] |
2. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
3. Huijie Gao, Yan Ren, Chao Liu. (2022) Aloe-Emodin Suppresses Oxidative Stress and Inflammation via a PI3K-Dependent Mechanism in a Murine Model of Sepsis. Evidence-based Complementary and Alternative Medicine, 2022 (9697887). [PMID:35978995] [10.1155/2022/9697887] |
4. Yuanyuan Song, Ziqi Wang, Yijing Long, Yang Mao, Feng Jiang, Yuanyuan Lu. (2022) 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. RESEARCH IN MICROBIOLOGY, 173 (103955). [PMID:35550403] [10.1016/j.resmic.2022.103955] |
5. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] [10.3389/fphar.2022.842720] |
6. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] [10.3390/foods11030386] |
7. Chi Chen, Zhuang Fu, Weiying Zhou, Qiushi Chen, Chenzhao Wang, Lu Xu, Zhibing Wang, Hanqi Zhang. (2020) Ionic liquid-immobilized NaY zeolite-based matrix solid phase dispersion for the extraction of active constituents in Rheum palmatum L.. MICROCHEMICAL JOURNAL, 152 (104245). [PMID:] [10.1016/j.microc.2019.104245] |
8. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [PMID:] [10.1016/j.snb.2019.04.129] |
9. Jian Lu, Yingying Qin, Qi Zhang, Chao Yu, Yilin Wu, Yongsheng Yan, Hougang Fan, Minjia Meng, Chunxiang Li. (2019) Antibacterial, high-flux and 3D porous molecularly imprinted nanocomposite sponge membranes for cross-flow filtration of emodin from analogues. CHEMICAL ENGINEERING JOURNAL, 360 (483). [PMID:] [10.1016/j.cej.2018.12.014] |
10. Wang Qianqian, Xu Yixiang, Xu Jiaqi, Wang Xudong, Shen Chen, Zhang Yan, Liu Xiufeng, Yu Boyang, Zhang Jian. (2017) Molecular cloning and expression of a glycosyltransferase from Bacillus subtilis for modification of morin and related polyphenols. BIOTECHNOLOGY LETTERS, 39 (8): (1229-1235). [PMID:28484911] [10.1007/s10529-017-2352-z] |
11. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [PMID:] [10.1002/app.44874] |
12. Xingqiang Wu, Shuxuan Liang, Xusheng Ge, Yunkai Lv, Hanwen Sun. (2015) Synthesis and evaluation of dummy molecularly imprinted microspheres for the specific solid-phase extraction of six anthraquinones from slimming tea. JOURNAL OF SEPARATION SCIENCE, 38 (8): (1263-1270). [PMID:25677958] [10.1002/jssc.201401341] |
13. Gong Hao, He Zihao, Peng Anlin, Zhang Xin, Cheng Biao, Sun Yue, Zheng Ling, Huang Kun. (2014) Effects of several quinones on insulin aggregation. Scientific Reports, 4 (1): (1-8). [PMID:25008537] [10.1038/srep05648] |
1. Baqi Y, Atzler K, Köse M, Glänzel M, Müller CE. (2009) High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.. J Med Chem, 52 (12): (3784-93). [PMID:19463000] [10.1021/op500134e] |
2. Tom Coenye,Kris Honraet,Petra Rigole,Pol Nadal Jimenez,Hans J Nelis. (2007-01-16) In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones.. Antimicrobial agents and chemotherapy, 51 ((4)): (1541-1544). [PMID:17220400] |
3. Xing-Ri Cui,Maiko Tsukada,Nao Suzuki,Takeshi Shimamura,Li Gao,Jyunichi Koyanagi,Fusao Komada,Setsuo Saito. (2007-10-24) Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.. European journal of medicinal chemistry, 43 ((6)): (1206-1215). [PMID:17949858] |
4. Junko Koyama,Yu Nisino,Izumi Morita,Norihiro Kobayashi,Toshiyuki Osakai,Harukuni Tokuda. (2008-06-17) Correlation between reduction potentials and inhibitions of Epstein-Barr virus activation by anthraquinone derivatives.. Bioorganic & medicinal chemistry letters, 18 ((14)): (4106-4109). [PMID:18556196] |
5. Francesca Sorrentino,Anastasia Karioti,Paola Gratteri,Maria Pia Rigobello,Guido Scutari,Luigi Messori,Alberto Bindoli,Matteo Chioccioli,Chiara Gabbiani,Maria Camilla Bergonzi,Anna Rita Bilia. (2010-11-26) Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.. Bioorganic & medicinal chemistry, 19 ((1)): (631-641). [PMID:21106380] |
6. Khalilah Haris,Samhani Ismail,Zamzuri Idris,Jafri Malin Abdullah,Abdul Aziz Mohamed Yusoff. (2014-06-28) Expression profile of genes modulated by Aloe emodin in human U87 glioblastoma cells.. Asian Pacific journal of cancer prevention : APJCP, 15 ((11)): (4499-4505). [PMID:24969876] |
7. Naraganahalli R Thimmegowda,Chanmi Park,Bettaswamigowda Shwetha,Krisada Sakchaisri,Kangdong Liu,Joonsung Hwang,Sangku Lee,Sook J Jeong,Nak K Soung,Jae H Jang,In-Ja Ryoo,Jong S Ahn,Raymond L Erikson,Bo Y Kim. (2014-10-18) Synthesis and antitumor activity of natural compound aloe emodin derivatives.. Chemical biology & drug design, 85 ((5)): (638-644). [PMID:25323822] |
8. Mildred Acevedo-Duncan,Christopher Russell,Sapna Patel,Rekha Patel. (2004-11-09) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells.. International immunopharmacology, 4 ((14)): (1775-1784). [PMID:15531293] |
9. Xia Zhou,Baoan Song,Linhong Jin,Deyu Hu,Chunling Diao,Guangfang Xu,Zhihui Zou,Song Yang. (2005-11-09) Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb.. Bioorganic & medicinal chemistry letters, 16 ((3)): (563-568). [PMID:16275083] |
10. Jun-ming Guo,Bing-xiu Xiao,Qiong Liu,Shun Zhang,Dong-hai Liu,Zhao-hui Gong. (2007-11-23) Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation.. Acta pharmacologica Sinica, 28 ((12)): (1991-1995). [PMID:18031614] |
11. Yiqun Du,Jian Zhang,Zhonghua Tao,Chenchen Wang,Shiyan Yan,Xiaowei Zhang,Mingzhu Huang. (2019-05-28) Aloe emodin exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential (ΛΨm).. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 24 ((2)): (746-753). [PMID:31128032] |
12. Wenbin Chen, Airi N. Kato, Lijun Dai, Paul S. Clegg, Tao Li. (2023) Continuous Emulsion Channels Achieved by Controlling the Aqueous–Oil Interface Solely with Rough Colloids. ADVANCED FUNCTIONAL MATERIALS, 34 (6): (2308608). [PMID:9647693] [10.1002/adfm.202308608] |
13. Mengsi Zhang, Lu Wang, Hao Jin, Nan Zhao, Yi Liu, Shijie Lan, Shuwei Liu, Hao Zhang. (2023) Employing single valency polyphenol to prepare metal-phenolic network antitumor reagents through FeOOH assistance. JOURNAL OF CONTROLLED RELEASE, 358 (612). [PMID:37196899] [10.1016/j.jconrel.2023.05.020] |
14. Huijie Gao, Yan Ren, Chao Liu. (2022) Aloe-Emodin Suppresses Oxidative Stress and Inflammation via a PI3K-Dependent Mechanism in a Murine Model of Sepsis. Evidence-based Complementary and Alternative Medicine, 2022 (9697887). [PMID:35978995] [10.1155/2022/9697887] |
15. Yuanyuan Song, Ziqi Wang, Yijing Long, Yang Mao, Feng Jiang, Yuanyuan Lu. (2022) 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. RESEARCH IN MICROBIOLOGY, 173 (103955). [PMID:35550403] [10.1016/j.resmic.2022.103955] |
16. Rui Wang, Baifei Hu, Cheng Ye, Zhigang Zhang, Mingzhu Yin, Qiushi Cao, Yuanming Ba, Hongtao Liu. (2022) Stewed Rhubarb Decoction Ameliorates Adenine-Induced Chronic Renal Failure in Mice by Regulating Gut Microbiota Dysbiosis. Frontiers in Pharmacology, 13 (842720). [PMID:35392552] [10.3389/fphar.2022.842720] |
17. Ying Xu, Xuan Yu, Jiaqi Gui, Yiqun Wan, Jinping Chen, Ting Tan, Fan Liu, Lan Guo. (2022) Ultrasonic Solvent Extraction Followed by Dispersive Solid Phase Extraction (d-SPE) Cleanup for the Simultaneous Determination of Five Anthraquinones in Polygonum multiflorum by UHPLC-PDA. Foods, 11 (3): (386). [PMID:35159536] [10.3390/foods11030386] |
18. Chi Chen, Zhuang Fu, Weiying Zhou, Qiushi Chen, Chenzhao Wang, Lu Xu, Zhibing Wang, Hanqi Zhang. (2020) Ionic liquid-immobilized NaY zeolite-based matrix solid phase dispersion for the extraction of active constituents in Rheum palmatum L.. MICROCHEMICAL JOURNAL, 152 (104245). [PMID:] [10.1016/j.microc.2019.104245] |
19. Qingqing Hao, Lilin Lu, Xianwen Kan. (2019) Probe and analogue: Double roles of thionine for aloe-emodin selective and sensitive ratiometric detection. SENSORS AND ACTUATORS B-CHEMICAL, 292 (247). [PMID:] [10.1016/j.snb.2019.04.129] |
20. Jian Lu, Yingying Qin, Qi Zhang, Chao Yu, Yilin Wu, Yongsheng Yan, Hougang Fan, Minjia Meng, Chunxiang Li. (2019) Antibacterial, high-flux and 3D porous molecularly imprinted nanocomposite sponge membranes for cross-flow filtration of emodin from analogues. CHEMICAL ENGINEERING JOURNAL, 360 (483). [PMID:] [10.1016/j.cej.2018.12.014] |
21. Wang Qianqian, Xu Yixiang, Xu Jiaqi, Wang Xudong, Shen Chen, Zhang Yan, Liu Xiufeng, Yu Boyang, Zhang Jian. (2017) Molecular cloning and expression of a glycosyltransferase from Bacillus subtilis for modification of morin and related polyphenols. BIOTECHNOLOGY LETTERS, 39 (8): (1229-1235). [PMID:28484911] [10.1007/s10529-017-2352-z] |
22. Xiaoya Jiang, Xiaoyan Jiao, Doudou Zhang, Ligai Bai, Haiyan Liu, Hongyuan Yan. (2017) Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatum L.. JOURNAL OF APPLIED POLYMER SCIENCE, 134 (21): [PMID:] [10.1002/app.44874] |
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