ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Product Description
ALS-8112 is a potent and selective respiratory syncytial virus ( RSV ) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC 50 of 0.02 μM.
In Vitro
The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro . The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC 50 of 0.020 ± 0.008 μM . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
