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ALT-803, Agonist of Interleukin-15 receptor

  • Moligand™
Features and benefits
    Item Number
    Ab175449
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    Ab175449-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,668.90
    Ab175449-5mg
    5mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $4,668.90
    View related series
    Interleukin-15 receptor Agonist

    Basic Description

    Product NameALT-803
    SynonymsIL-15 N72D:IL-15RαSu/Fc;IL-15SA;N-803
    GradeMoligand™
    Action TypeAGONIST
    Mechanism of actionAgonist of Interleukin-15 receptor

    Product Properties

    CASAb175449

    Associated Targets

    IL2RB Tclin Interleukin-2 receptor subunit beta 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    IL15RA Tbio Interleukin-15 receptor subunit alpha 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    IL2RG Tclin Cytokine receptor common subunit gamma 0 Activities

    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Certificates

    Certificate of Analysis(COA)

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    Related Documents

    References

    1. Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA et al..  (2011)  IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization..  Cytokine,  56  (3): (804-10).  [PMID:22019703]
    2. Rhode PR, Egan JO, Xu W, Hong H, Webb GM, Chen X, Liu B, Zhu X, Wen J, You L et al..  (2016)  Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models..  Cancer Immunol Res,  (1): (49-60).  [PMID:26511282]
    3. Robinson TO, Schluns KS.  (2017)  The potential and promise of IL-15 in immuno-oncogenic therapies..  Immunol Lett,  190  (3): (159-168).  [PMID:28823521]
    4. Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, Weisdorf DJ, Blazar BR, Ustun C, DeFor TE et al..  (2018)  First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation..  Blood,  131  (23): (2515-2527).  [PMID:29463563]
    5. Wrangle JM, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel JG, Miller JS, Farhad M, Anderton K, Lindsey K et al..  (2018)  ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial..  Lancet Oncol,  19  (5): (694-704).  [PMID:29628312]
    6. Margolin K, Morishima C, Velcheti V, Miller JS, Lee SM, Silk AW, Holtan SG, Lacroix AM, Fling SP, Kaiser JC et al..  (2018)  Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors..  Clin Cancer Res,  24  (22): (5552-5561).  [PMID:30045932]
    7. Van der Meer JMR, Maas RJA, Guldevall K, Klarenaar K, de Jonge PKJD, Evert JSH, van der Waart AB, Cany J, Safrit JT, Lee JH et al..  (2021)  IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells..  Cancer Immunol Immunother,  70  (5): (1305-1321).  [PMID:33140189]
    8. Huang J, Shiao SL, Furuya H, Rosser CJ.  (2019)  Immunogenomic Analysis of Exceptional Responder to ALT-803 (IL-15 Analogue) in BCG Unresponsive Nonmuscle Invasive Bladder Cancer: A Case Series and Review of the Literature..  J Immunother,  42  (9): (354-358).  [PMID:31107371]

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