Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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Ab175449-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,668.90 | |
Ab175449-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $4,668.90 |
Product Name | ALT-803 |
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Synonyms | IL-15 N72D:IL-15RαSu/Fc;IL-15SA;N-803 |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of Interleukin-15 receptor |
CAS | Ab175449 |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Enter Lot Number to search for COA:
1. Han KP, Zhu X, Liu B, Jeng E, Kong L, Yovandich JL, Vyas VV, Marcus WD, Chavaillaz PA, Romero CA et al.. (2011) IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization.. Cytokine, 56 (3): (804-10). [PMID:22019703] |
2. Rhode PR, Egan JO, Xu W, Hong H, Webb GM, Chen X, Liu B, Zhu X, Wen J, You L et al.. (2016) Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models.. Cancer Immunol Res, 4 (1): (49-60). [PMID:26511282] |
3. Robinson TO, Schluns KS. (2017) The potential and promise of IL-15 in immuno-oncogenic therapies.. Immunol Lett, 190 (3): (159-168). [PMID:28823521] |
4. Romee R, Cooley S, Berrien-Elliott MM, Westervelt P, Verneris MR, Wagner JE, Weisdorf DJ, Blazar BR, Ustun C, DeFor TE et al.. (2018) First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation.. Blood, 131 (23): (2515-2527). [PMID:29463563] |
5. Wrangle JM, Velcheti V, Patel MR, Garrett-Mayer E, Hill EG, Ravenel JG, Miller JS, Farhad M, Anderton K, Lindsey K et al.. (2018) ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial.. Lancet Oncol, 19 (5): (694-704). [PMID:29628312] |
6. Margolin K, Morishima C, Velcheti V, Miller JS, Lee SM, Silk AW, Holtan SG, Lacroix AM, Fling SP, Kaiser JC et al.. (2018) Phase I Trial of ALT-803, A Novel Recombinant IL15 Complex, in Patients with Advanced Solid Tumors.. Clin Cancer Res, 24 (22): (5552-5561). [PMID:30045932] |
7. Van der Meer JMR, Maas RJA, Guldevall K, Klarenaar K, de Jonge PKJD, Evert JSH, van der Waart AB, Cany J, Safrit JT, Lee JH et al.. (2021) IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor-derived NK cells.. Cancer Immunol Immunother, 70 (5): (1305-1321). [PMID:33140189] |
8. Huang J, Shiao SL, Furuya H, Rosser CJ. (2019) Immunogenomic Analysis of Exceptional Responder to ALT-803 (IL-15 Analogue) in BCG Unresponsive Nonmuscle Invasive Bladder Cancer: A Case Series and Review of the Literature.. J Immunother, 42 (9): (354-358). [PMID:31107371] |