Altholactone - ≥95% (LC/MS-ELSD), high purity , CAS No.65408-91-5

  • ≥95%(LC/MS-ELSD)
Item Number
A463869
Grouped product items
SKUSizeAvailabilityPrice Qty
A463869-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$654.90

Basic Description

SynonymsFS-9444 | ALTHOLACTONE | Altholactone, >=95% (LC/MS-ELSD) | DTXSID90331855 | Goniothalenol | (+)-Altholactone | AC1L9CZK | C09930 | Q27106790 | (2R,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrofuro[3,2-b]pyran-5-one | AKOS032948434 | CHEBI:5522 | ZI
Specifications & Purity≥95%(LC/MS-ELSD)
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Description

Natural product derived from plant source.}

Associated Targets(Human)

CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF-10A (2462 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LNCaP (8286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Artemia salina (1320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lactuca sativa (1092 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (2R,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrofuro[3,2-b]pyran-5-one
INCHI InChI=1S/C13H12O4/c14-10-7-6-9-13(17-10)11(15)12(16-9)8-4-2-1-3-5-8/h1-7,9,11-13,15H/t9-,11+,12+,13+/m0/s1
InChi Key ZKIRVBNLJKGIEM-WKSBVSIWSA-N
Canonical SMILES C1=CC=C(C=C1)C2C(C3C(O2)C=CC(=O)O3)O
Isomeric SMILES C1=CC=C(C=C1)[C@@H]2[C@H]([C@H]3[C@@H](O2)C=CC(=O)O3)O
PubChem CID 442513
UN Number 2811
Molecular Weight 232.23

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Flash Point(°F)Not applicable
Flash Point(°C)Not applicable

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

Class 6.1
RIDADR UN 2811 6.1 / PGIII

Related Documents

References

1. Ze Tian,Sibao Chen,Yaòu Zhang,Minghui Huang,Lin Shi,Feng Huang,Chichun Fong,Mengsu Yang,Peigen Xiao.  (2006-01-24)  The cytotoxicity of naturally occurring styryl lactones..  Phytomedicine : international journal of phytotherapy and phytopharmacology,  13  ((3)): (181-186).  [PMID:16428026]
2. Barry M Trost,Aaron Aponick,Benjamin N Stanzl.  (2007-09-12)  A convergent Pd-catalyzed asymmetric allylic alkylation of dl- and meso-divinylethylene carbonate: enantioselective synthesis of (+)-australine hydrochloride and formal synthesis of isoaltholactone..  Chemistry (Weinheim an der Bergstrasse, Germany),  13  ((34)): (9547-9560).  [PMID:17847148]
3. Dieter Enders,Julien Barbion.  (2008-01-26)  Asymmetric synthesis of (+)-altholactone: a styryllactone isolated from various Goniothalamus species..  Chemistry (Weinheim an der Bergstrasse, Germany),  14  ((9)): (2842-2849).  [PMID:18219645]
4. William P Unsworth,Kiri Stevens,Scott G Lamont,Jeremy Robertson.  (2011-06-15)  Stereospecificity in the Au-catalysed cyclisation of monoallylic diols. Synthesis of (+)-isoaltholactone..  Chemical communications (Cambridge, England),  47  ((27)): (7659-7661).  [PMID:21666896]
5. Nizar M Mhaidat,Kalid K Abdul-Razzak,Ahmad S Alkofahi,Aseera M Alsarhan,Ahmad N Aldaher,Rick F Thorne.  (2011-11-23)  Altholactone induces apoptotic cell death in human colorectal cancer cells..  Phytotherapy research : PTR,  26  ((6)): (926-931).  [PMID:22105918]
6. Kavirayani R Prasad,Shivajirao L Gholap.  (2007-05-26)  Stereoselective total synthesis of bioactive styryllactones (+)-goniofufurone, (+)7-epi-goniofufurone, (+)-goniopypyrone, (+)-goniotriol, (+)-altholactone, and (-)-etharvensin..  The Journal of organic chemistry,  73  ((1)): (2-11).  [PMID:17523660]
7. Shuchi Gupta,Lee Poeppelman,Channing L Hinman,James Bretz,Richard A Hudson,L M Viranga Tillekeratne.  (2009-12-29)  Apoptotic activities in closely related styryllactone stereoisomers toward human tumor cell lines: Investigation of synergism of styryllactone-induced apoptosis with TRAIL..  Bioorganic & medicinal chemistry,  18  ((2)): (849-854).  [PMID:20036566]
8. Fouad Al Momani,Ahmad S Alkofahi,Nizar M Mhaidat.  (2011-06-07)  Altholactone displays promising antimicrobial activity..  Molecules (Basel, Switzerland),  16  ((6)): (4560-4566).  [PMID:21642933]

Solution Calculators