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Alvespimycin - 98%, high purity , CAS No.467214-20-6, Inhibitor of heat shock protein 90 alpha family class A member 1

Moligand™
≥98%

CAS#: 467214-20-6
Formula: C₃₂H₄₈N₄O₈
Molecular Weight: 616.75
PubChem CID: 5288674

Item Number

A125535

Grouped product items
SKU	Size	Availability	Price	Qty
A125535-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$309.90
A125535-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$927.90

View related series

heat shock protein 90 alpha family class A member 1 Inhibitor

Basic Description

Synonyms	alvespimycin\|467214-20-6\|17-DMAG\|DMAG\|Alvespimycin [INN]\|KOS1022\|17-dimethylaminoethylamino-17-demethoxygeldanamycin\|KOS 1022\|CHEBI:65324\|17-(dimethylaminoethylamino)-17-demethoxygeldanamycin\|150270-08-9\|17-DESMETHOXY-17-N,N-DIMETHYLAMINOETHYLAMINO-GELDAN
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of heat shock protein 90 alpha family class A member 1
Product Description	A synthetic Geldanamycin derivative and inhibitor of Hsp90.

Associated Targets

HSP90AA1 Tchem Heat shock protein HSP 90-alpha 6 Activities

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AB1 Tchem Heat shock protein HSP 90-beta 4 Activities

Discover Target: HSP90AB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha 2 Activities

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
INCHI	InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1
InChi Key	KUFRQPKVAWMTJO-LMZWQJSESA-N
Canonical SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Alternate CAS	467214-20-6
PubChem CID	5288674
MeSH Entry Terms	17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin;17-(dimethylaminoethylamino)-17-demethoxygeldanamycin;17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin;17-dimethylaminoethylamino-17-demethoxy-geldanamycin;17-DMAG;17DMAG;alvespimycin;KOS 102
Molecular Weight	616.75

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Lot Number	Certificate Type	Date	Item
E1518062	Certificate of Analysis	Nov 11, 2022	A125535

References

1. Jhaveri K, Miller K, Rosen L, Schneider B, Chap L, Hannah A, Zhong Z, Ma W, Hudis C, Modi S. (2012) A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors.. Clin Cancer Res, 18 (18): (5090-8). [PMID:22781552]

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