Skip to the beginning of the images gallery

Alvespimycin - 98%, high purity , CAS No.467214-20-6, Inhibitor of heat shock protein 90 alpha family class A member 1

1 Citations

Moligand™

≥98%

CAS#: 467214-20-6
Formula: C₃₂H₄₈N₄O₈
Molecular Weight: 616.75
PubChem CID: 5288674

Item Number

A125535

Grouped product items
SKU	Size	Availability	Price	Qty
A125535-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$309.90
A125535-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$927.90

View related series

Cell Cycle/DNA Damage heat shock protein 90 alpha family class A member 1 Inhibitor HSP Metabolic Enzyme/Protease

Basic Description

Synonyms	NSC 707545 \| (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-{[2-(dimethylamino)ethyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate \| 17-DMAG \| ((4E,6Z,8S,9S,10E,12S,13R,14S,1
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, is a synthetic derivative of the antibiotic Geldanamycin with lower hepatotoxicity than the parent antibiotic and higher potency and availability than the similar derivative 17-AAG .17-DMAG is
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of heat shock protein 90 alpha family class A member 1
Note	100mg卖完停产，不再备货
Product Description	A synthetic Geldanamycin derivative and inhibitor of Hsp90.

Associated Targets(Human)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha (6 Activities)

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AB1 Tchem Heat shock protein HSP 90-beta (4 Activities)

Discover Target: HSP90AB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HIF1A Tchem Hypoxia-inducible factor 1-alpha (2 Activities)

Discover Target: HIF1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate
INCHI	InChI=1S/C32H48N4O8/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40)/b11-9-,19-10+,21-16+/t18-,20+,25+,26+,28-,30+/m1/s1
InChi Key	KUFRQPKVAWMTJO-LMZWQJSESA-N
Canonical SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Alternate CAS	467214-20-6
PubChem CID	5288674
MeSH Entry Terms	17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin;17-(dimethylaminoethylamino)-17-demethoxygeldanamycin;17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin;17-dimethylaminoethylamino-17-demethoxy-geldanamycin;17-DMAG;17DMAG;alvespimycin;KOS 102
Molecular Weight	616.75

Lot Number

Certificate Type

Date

Item

E1518062

Certificate of Analysis

Nov 11, 2022

A125535

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, 13 [PMID:36726786] [10.3389/fphar.2022.1089217]

References

1. Jhaveri K, Miller K, Rosen L, Schneider B, Chap L, Hannah A, Zhong Z, Ma W, Hudis C, Modi S. (2012) A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors.. Clin Cancer Res, 18 (18): (5090-8). [PMID:22781552] [10.1021/op500134e]
2. Li Peng, Bai Chujie, Zhan Lingmin, Zhang Haoran, Zhang Yuanyuan, Zhang Wuxia, Wang Yingdong, Zhao Jinzhong. (2023) Specific gene module pair-based target identification and drug discovery. Frontiers in Pharmacology, 13 [PMID:36726786] [10.3389/fphar.2022.1089217]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Alvespimycin - 98%, high purity , CAS No.467214-20-6, Inhibitor of heat shock protein 90 alpha family class A member 1

Basic Description

Associated Targets(Human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator