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AM 6545 - ≥98%(HPLC), high purity , CAS No.1245626-05-4, Antagonist of CB 1 receptor
High affinity and selective CB1antagonist
Basic Description Synonyms SCHEMBL662200 | AM6545, >=98% (HPLC) | Q4652496 | 1245626-05-4 | 5-[4-(4-cyanobut-1-ynyl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1,4-thiazinan-4-yl)-4-methylpyrazole-3-carboxamide | VZB62605 | CS-0033070 | HY-110206 | AM 6545 | GTPL10029 | AM6545 | AM Specifications & Purity Moligand™, ≥98%(HPLC) Biochemical and Physiological Mechanisms High affinity and selective CB1antagonist (Ki= 3.3 nM). Exhibits >100-fold selectivity for CB1over CB2receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain pe Storage Temp Store at 2-8°C Shipped In Wet ice Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of CB 1 receptor
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-[4-(4-cyanobut-1-ynyl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1,4-thiazinan-4-yl)-4-methylpyrazole-3-carboxamide INCHI InChI=1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34) InChi Key XBHQLFVDGLPBCK-UHFFFAOYSA-N Canonical SMILES CC1=C(N(N=C1C(=O)NN2CCS(=O)(=O)CC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)C#CCCC#N Isomeric SMILES CC1=C(N(N=C1C(=O)NN2CCS(=O)(=O)CC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)C#CCCC#N PubChem CID 46912919 Molecular Weight 556.46
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 11.13, Max Conc. mM: 20
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H319: Causes serious eye irritation
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
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