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AM1241 - ≥98%, high purity , CAS No.444912-48-5, Agonist of CB 2 receptor

Moligand™
≥98%

CAS#: 444912-48-5
Formula: C₂₂H₂₂IN₃O₃
Molecular Weight: 503.33
EC Number: 636-937-2
PubChem CID: 10141893

Item Number

A129838

Grouped product items
SKU	Size	Availability	Price
A129838-1mg	1mg	In stock	$26.90
A129838-5mg	5mg	In stock	$102.90
A129838-10mg	10mg	In stock	$149.90
A129838-25mg	25mg	In stock	$252.90
A129838-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$454.90

Potent, selective CB 2 agonist

View related series

CB2 receptor Agonist

Basic Description

Synonyms	444912-48-5\|AM1241\|AM-1241\|(2-iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)methanone\|(R,S)-AM1241\|DLM851L3RD\|(1-(Methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole)\|(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	AM-1241 is a protean agonist of CB2 based on the different effect observed in various assays (calcium influx, extracellular signal-regulated kinase (ERK) phosphorylatin and cAMP measurement)) and on the switch from neutral antagonism to agonism in the cAM
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of CB 2 receptor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. (R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal models

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 0 Activities

Discover Target: CNR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CNR2 Tchem Cannabinoid receptor 2 12 Activities

Discover Target: CNR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Discover Target: TDP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
INCHI	InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3
InChi Key	ZUHIXXCLLBMBDW-UHFFFAOYSA-N
Canonical SMILES	CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I
Isomeric SMILES	CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I
WGK Germany	3
Alternate CAS	444912-48-5
PubChem CID	10141893
MeSH Entry Terms	AM 1241;AM1241
Molecular Weight	503.33

Certificates

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5 results found

Lot Number	Certificate Type	Date	Item
K2103414	Certificate of Analysis	Aug 04, 2023	A129838
K2103416	Certificate of Analysis	Aug 04, 2023	A129838
K2103424	Certificate of Analysis	Aug 04, 2023	A129838
K2103425	Certificate of Analysis	Aug 04, 2023	A129838
K2103427	Certificate of Analysis	Aug 04, 2023	A129838

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P284:[In case of inadequate ventilation] Wear respiratory protection. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.
WGK Germany	3

References

1. Niu J et al.. (2017) Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12and P2Y13receptors in neuropathic pain rats.. J Neuroinflammation, 14 (185). [PMID:28899427]
2. Zhou S et al.. (2021) Cannabinoid receptor 2 plays a central role in renal tubular mitochondrial dysfunction and kidney ageing.. J Cell Mol Med, 25 (18): (8957-8972). [PMID:34414658]
3. Li MH et al.. (2017) Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain.. J Neurosci, 37 (3): (626-636). [PMID:28100744]
4. Abd El-Rahman SS & Fayed HM. (2022) Improved cognition impairment by activating cannabinoid receptor type 2: Modulating CREB/BDNF expression and impeding TLR-4/NF?Bp65/M1 microglia signaling pathway in D-galactose-injected ovariectomized rats.. PLoS One, 17 (3): (e0265961). [PMID:35349580]
5. Ali AM et al.. (2021) Promoted inhibition of TLR4/miR-155/ NFkB p65 signaling by cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide.. Chem Biol Interact, 336 (109398). [PMID:33503444]

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