AM-1241 is a protean agonist of CB2 based on the different effect observed in various assays (calcium influx, extracellular signal-regulated kinase (ERK) phosphorylatin and cAMP measurement)) and on the switch from neutral antagonism to agonism in the cAM
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of CB 2 receptor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor. (R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal models
1.Niu J et al.. (2017) Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12and P2Y13receptors in neuropathic pain rats.. J Neuroinflammation, 14 (185). [PMID:28899427]
2.Zhou S et al.. (2021) Cannabinoid receptor 2 plays a central role in renal tubular mitochondrial dysfunction and kidney ageing.. J Cell Mol Med, 25 (18):(8957-8972). [PMID:34414658]
3.Li MH et al.. (2017) Compensatory Activation of Cannabinoid CB2 Receptor Inhibition of GABA Release in the Rostral Ventromedial Medulla in Inflammatory Pain.. J Neurosci, 37 (3):(626-636). [PMID:28100744]
4.Abd El-Rahman SS & Fayed HM. (2022) Improved cognition impairment by activating cannabinoid receptor type 2: Modulating CREB/BDNF expression and impeding TLR-4/NF?Bp65/M1 microglia signaling pathway in D-galactose-injected ovariectomized rats.. PLoS One, 17 (3):(e0265961). [PMID:35349580]
5.Ali AM et al.. (2021) Promoted inhibition of TLR4/miR-155/ NFkB p65 signaling by cannabinoid receptor 2 agonist (AM1241), aborts inflammation and progress of hepatic fibrosis induced by thioacetamide.. Chem Biol Interact, 336 (109398). [PMID:33503444]
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K2103414