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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A276517-10mg | 10mg | In stock | $97.90 | |
A276517-50mg | 50mg | In stock | $401.90 | |
A276517-250mg | 250mg | In stock | $1,809.90 |
Selective RARα agonists
Synonyms | AM580 | 102121-60-8 | Am 580 | AM-580 | 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)benzoic acid | Ro 40-6055 | CD-336 | 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid | CD 336 | DTXSID5040758 | NSC608001 | VZ5S5G9 |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Selective RARα agonists (EC 50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo. |
Source | Synthetic |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Describtion: AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. |
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IUPAC Name | 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid |
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INCHI | InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26) |
InChi Key | SZWKGOZKRMMLAJ-UHFFFAOYSA-N |
Canonical SMILES | CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C |
Isomeric SMILES | CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C |
PubChem CID | 2126 |
Molecular Weight | 351.44 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
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G2226006 | Certificate of Analysis | May 10, 2023 | A276517 |
G2226007 | Certificate of Analysis | May 10, 2023 | A276517 |
G2226011 | Certificate of Analysis | May 10, 2023 | A276517 |
Solubility | Soluble in DMSO (20mg/ml) or ethanol (10mg/ml) |
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Sensitivity | Heat sensitive |
Melt Point(°C) | 260 °C |