Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A276517-10mg | 10mg | In stock | $97.90 | |
A276517-50mg | 50mg | In stock | $401.90 | |
A276517-250mg | 250mg | In stock | $1,809.90 |
Selective RARα agonists
Synonyms | Ro406055 | Ro-40-6055 | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid | CS-3251 | AM580 (GMP) | BCP9000281 | BML2-E09 | CS-0622773 | NSC 608001 | AM580 | AM-580 | FT-0738259 | 4-[(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Selective RARα agonists (EC 50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Shows anticancer effect. Active in vivo. |
Source | Synthetic |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Describtion: AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid |
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INCHI | InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26) |
InChi Key | SZWKGOZKRMMLAJ-UHFFFAOYSA-N |
Canonical SMILES | CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C |
Isomeric SMILES | CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C |
PubChem CID | 2126 |
Molecular Weight | 351.44 |
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Solubility | Soluble in DMSO (20mg/ml) or ethanol (10mg/ml) |
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Sensitivity | Heat sensitive |
Melt Point(°C) | 260 °C |