Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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A109736-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $64.90 | |
A109736-10g | 10g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $90.90 | |
A109736-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $204.90 | |
A109736-100g | 100g | In stock | $737.90 | |
A109736-500g | 500g | In stock | $3,316.90 |
Dopaminergic agent. Antiviral.
Synonyms | AKOS015951188 | AMANTADINE HYDROCHLORIDE [MART.] | s2451 | Tricyclo(3.3.1.13,7)decan-1-amine, hydrochloride | AMANTADINE HYDROCHLORIDE [USP MONOGRAPH] | Symmetrel (TN) | Amantadinehydrochloride | NC00489 | SCHEMBL40713 | Adamantanamine hydrochloride | MLS |
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Specifications & Purity | ≥99%(T) |
Biochemical and Physiological Mechanisms | Antiviral agent. Dopaminergic agent. Binds to M2 proton-selective ion channel of influenza. Uncompetitive NMDA receptor antagonist. Inhibits dopamine reuptake and induces D 2 and D 3 upregulation. Shows antiviral, antiparkinsonian and neuroprotective effe |
Storage Temp | Desiccated |
Shipped In | Normal |
Action Type | ANTAGONIST |
Mechanism of action | Matrix protein 2 inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | adamantan-1-amine;hydrochloride |
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INCHI | InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H |
InChi Key | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
Canonical SMILES | C1C2CC3CC1CC(C2)(C3)N.Cl |
Isomeric SMILES | C1C2CC3CC1CC(C2)(C3)N.Cl |
WGK Germany | 3 |
RTECS | AU4375000 |
PubChem CID | 64150 |
Molecular Weight | 187.71 |
Beilstein | 4198854 |
Reaxy-Rn | 4198854 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
D2418166 | Certificate of Analysis | Mar 25, 2024 | A109736 |
D2418167 | Certificate of Analysis | Mar 25, 2024 | A109736 |
D2418168 | Certificate of Analysis | Mar 25, 2024 | A109736 |
I1905117 | Certificate of Analysis | Jun 09, 2023 | A109736 |
I2209100 | Certificate of Analysis | Jul 04, 2022 | A109736 |
I2209103 | Certificate of Analysis | Jul 04, 2022 | A109736 |
I2209104 | Certificate of Analysis | Jul 04, 2022 | A109736 |
I2209110 | Certificate of Analysis | Jul 04, 2022 | A109736 |
I2318162 | Certificate of Analysis | Jul 04, 2022 | A109736 |
Solubility | Soluble in water (50 mg/ml), ethanol (38 mg/ml at 25°C), chloroform (1:18), DMSO (38 mg/ml at 25°C), and methanol |
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Sensitivity | Hygroscopic. |
Melt Point(°C) | >360°C |
Pictogram(s) | GHS08, GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H314:Causes severe skin burns and eye damage H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed H318:Causes serious eye damage H336:May cause drowsiness or dizziness H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | AU4375000 |
Reaxy-Rn | 4198854 |
1. Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu. (2023) Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications. Acta Biomaterialia, 168 (617). [PMID:37482147] [10.1016/j.actbio.2023.07.026] |
2. Lin Yuan, Lizhen Liu, Zhi Mi, Meng Chen, Yunfeng Bai, Jun Qin, Feng Feng. (2023) A ratiometric sensor based on dual-emission carbon dots sensitive detection of amaranth. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 302 (123058). [PMID:37393669] [10.1016/j.saa.2023.123058] |
3. Yu Fang, Haiyan Cui, Xiaoqin Liang, Jianping Yu, Jianrong Wang, Guanghui Zhao. (2022) Quaternary Ammonium-Tethered Phenylboronic Acids Appended Supramolecular Nanomicelles as a Promising Bacteria Targeting Carrier for Nitric Oxide Delivery. Polymers, 14 (20): (4451). [PMID:36298029] [10.3390/polym14204451] |
4. Junlian Wang, Wen Xu, Jianguo Cui, Guodong Xu, Yufu Chen, Peilong Wang, Ziyong Chang. (2023) The role of β, γ, δ-substituent of dialkylphosphinic acids in HREE extraction and separation behaviors. JOURNAL OF RARE EARTHS, 41 (1789). [PMID:] [10.1016/j.jre.2022.09.024] |
5. Yuan-Fu Ding, Jianwen Wei, Xingping Quan, Wenting Gu, Long Xi, Ying Zheng, Yonghua Zhao, Jingwei Luo, Shengke Li, Greta S.P. Mok, Ruibing Wang. (2022) Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis. CARBOHYDRATE POLYMERS, 296 (119968). [PMID:36088007] [10.1016/j.carbpol.2022.119968] |
6. Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu. (2023) Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery. Bioactive Materials, 19 (115). [PMID:35475030] [10.1016/j.bioactmat.2022.03.041] |
7. Pengfei Ren, Dandan Wei, Xin Ge, Faming Wang, Min Liang, Jidong Dai, Li Xu, Tianzhu Zhang. (2021) Injectable supramolecular hydrogels based on host–guest interactions with cell encapsulation capabilities. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 628 (127338). [PMID:] [10.1016/j.colsurfa.2021.127338] |
8. Chen Zhongyin, Liao Tao, Wan Lihui, Kuang Ying, Liu Chang, Duan Junlin, Xu Xiangyu, Xu Ziqiang, Jiang Bingbing, Li Cao. (2021) Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery. Nano Research, 14 (11): (4264-4273). [PMID:] [10.1007/s12274-021-3624-4] |
9. Hu Xiaohong, Gao Ziyu, Tan Huaping, Wang Huiming, Mao Xincheng, Pang Juan. (2019) An Injectable Hyaluronic Acid-Based Composite Hydrogel by DA Click Chemistry With pH Sensitive Nanoparticle for Biomedical Application. Frontiers in Chemistry, 7 [PMID:31334222] [10.3389/fchem.2019.00477] |
10. Jiagen Li, Peng Liu. (2018) One-pot fabrication of pH/reduction dual-stimuli responsive chitosan-based supramolecular nanogels for leakage-free tumor-specific DOX delivery with enhanced anti-cancer efficacy. CARBOHYDRATE POLYMERS, 201 (583). [PMID:30241856] [10.1016/j.carbpol.2018.08.102] |
11. Guo-Feng Luo, Wei-Hai Chen, Qi Lei, Wen-Xiu Qiu, Yu-Xin Liu, Yin-Jia Cheng, Xian-Zheng Zhang. (2016) A Triple-Collaborative Strategy for High-Performance Tumor Therapy by Multifunctional Mesoporous Silica-Coated Gold Nanorods. ADVANCED FUNCTIONAL MATERIALS, 26 (24): (4339-4350). [PMID:] [10.1002/adfm.201505175] |
12. Kongchang Wei, Meiling Zhu, Yuxin Sun, Jianbin Xu, Qian Feng, Sien Lin, Tianyi Wu, Jia Xu, Feng Tian, Jiang Xia, Gang Li, Liming Bian. (2016) Robust Biopolymeric Supramolecular “Host−Guest Macromer” Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration. MACROMOLECULES, 49 (3): (866–875). [PMID:] [10.1021/acs.macromol.5b02527] |
13. Shixiang Feng, Xu Zhang, Yanxiang Liu. (2015) New insights into the primary phototransformation of acetaminophen by UV/H2O2: photo-Fries rearrangement versus hydroxyl radical induced hydroxylation. WATER RESEARCH, 86 (35). [PMID:25997748] [10.1016/j.watres.2015.05.008] |
14. Junlian Wang, Guang Chen, Shengming Xu, Linyan Li. (2015) Synthesis of novel nonsymmetric dialkylphosphinic acid extractants and studies on their extraction–separation performance for heavy rare earths. HYDROMETALLURGY, 154 (129). [PMID:] [10.1016/j.hydromet.2015.04.001] |
15. Zhao Zheng-bai, An Shuang-shuang, Xie Hai-jiao, Jiang Yong. (2015) Copolymerization and properties of multicomponent crosslinked hydrogels. CHINESE JOURNAL OF POLYMER SCIENCE, 33 (1): (173-183). [PMID:] [10.1007/s10118-015-1565-7] |
16. Tian-Tian Yao,Jing Wang,Yun-Fan Xue,Wei-Jiang Yu,Qiang Gao,Lino Ferreira,Ke-Feng Ren,Jian Ji. (2019-08-23) A photodynamic antibacterial spray-coating based on the host-guest immobilization of the photosensitizer methylene blue.. Journal of materials chemistry. B, 7 ((33)): (5089-5095). [PMID:31432872] |
1. Qiuhui Hu, Bo Zhang, Huiming Ren, Xiaoxuan Zhou, Chengbin He, Youqing Shen, Zhuxian Zhou, Hongjie Hu. (2023) Supramolecular metal-organic frameworks as host-guest nanoplatforms for versatile and customizable biomedical applications. Acta Biomaterialia, 168 (617). [PMID:37482147] [10.1016/j.actbio.2023.07.026] |
2. Lin Yuan, Lizhen Liu, Zhi Mi, Meng Chen, Yunfeng Bai, Jun Qin, Feng Feng. (2023) A ratiometric sensor based on dual-emission carbon dots sensitive detection of amaranth. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 302 (123058). [PMID:37393669] [10.1016/j.saa.2023.123058] |
3. Yu Fang, Haiyan Cui, Xiaoqin Liang, Jianping Yu, Jianrong Wang, Guanghui Zhao. (2022) Quaternary Ammonium-Tethered Phenylboronic Acids Appended Supramolecular Nanomicelles as a Promising Bacteria Targeting Carrier for Nitric Oxide Delivery. Polymers, 14 (20): (4451). [PMID:36298029] [10.3390/polym14204451] |
4. Junlian Wang, Wen Xu, Jianguo Cui, Guodong Xu, Yufu Chen, Peilong Wang, Ziyong Chang. (2023) The role of β, γ, δ-substituent of dialkylphosphinic acids in HREE extraction and separation behaviors. JOURNAL OF RARE EARTHS, 41 (1789). [PMID:] [10.1016/j.jre.2022.09.024] |
5. Yuan-Fu Ding, Jianwen Wei, Xingping Quan, Wenting Gu, Long Xi, Ying Zheng, Yonghua Zhao, Jingwei Luo, Shengke Li, Greta S.P. Mok, Ruibing Wang. (2022) Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis. CARBOHYDRATE POLYMERS, 296 (119968). [PMID:36088007] [10.1016/j.carbpol.2022.119968] |
6. Jianhua He, Wenli Zhang, Xiaoju Zhou, Fengfei Xu, Jiahui Zou, Qiqi Zhang, Yi Zhao, Hongliang He, Hu Yang, Jianping Liu. (2023) Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage-targeted drug delivery. Bioactive Materials, 19 (115). [PMID:35475030] [10.1016/j.bioactmat.2022.03.041] |
7. Pengfei Ren, Dandan Wei, Xin Ge, Faming Wang, Min Liang, Jidong Dai, Li Xu, Tianzhu Zhang. (2021) Injectable supramolecular hydrogels based on host–guest interactions with cell encapsulation capabilities. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 628 (127338). [PMID:] [10.1016/j.colsurfa.2021.127338] |
8. Chen Zhongyin, Liao Tao, Wan Lihui, Kuang Ying, Liu Chang, Duan Junlin, Xu Xiangyu, Xu Ziqiang, Jiang Bingbing, Li Cao. (2021) Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery. Nano Research, 14 (11): (4264-4273). [PMID:] [10.1007/s12274-021-3624-4] |
9. Hu Xiaohong, Gao Ziyu, Tan Huaping, Wang Huiming, Mao Xincheng, Pang Juan. (2019) An Injectable Hyaluronic Acid-Based Composite Hydrogel by DA Click Chemistry With pH Sensitive Nanoparticle for Biomedical Application. Frontiers in Chemistry, 7 [PMID:31334222] [10.3389/fchem.2019.00477] |
10. Jiagen Li, Peng Liu. (2018) One-pot fabrication of pH/reduction dual-stimuli responsive chitosan-based supramolecular nanogels for leakage-free tumor-specific DOX delivery with enhanced anti-cancer efficacy. CARBOHYDRATE POLYMERS, 201 (583). [PMID:30241856] [10.1016/j.carbpol.2018.08.102] |
11. Guo-Feng Luo, Wei-Hai Chen, Qi Lei, Wen-Xiu Qiu, Yu-Xin Liu, Yin-Jia Cheng, Xian-Zheng Zhang. (2016) A Triple-Collaborative Strategy for High-Performance Tumor Therapy by Multifunctional Mesoporous Silica-Coated Gold Nanorods. ADVANCED FUNCTIONAL MATERIALS, 26 (24): (4339-4350). [PMID:] [10.1002/adfm.201505175] |
12. Kongchang Wei, Meiling Zhu, Yuxin Sun, Jianbin Xu, Qian Feng, Sien Lin, Tianyi Wu, Jia Xu, Feng Tian, Jiang Xia, Gang Li, Liming Bian. (2016) Robust Biopolymeric Supramolecular “Host−Guest Macromer” Hydrogels Reinforced by in Situ Formed Multivalent Nanoclusters for Cartilage Regeneration. MACROMOLECULES, 49 (3): (866–875). [PMID:] [10.1021/acs.macromol.5b02527] |
13. Shixiang Feng, Xu Zhang, Yanxiang Liu. (2015) New insights into the primary phototransformation of acetaminophen by UV/H2O2: photo-Fries rearrangement versus hydroxyl radical induced hydroxylation. WATER RESEARCH, 86 (35). [PMID:25997748] [10.1016/j.watres.2015.05.008] |
14. Junlian Wang, Guang Chen, Shengming Xu, Linyan Li. (2015) Synthesis of novel nonsymmetric dialkylphosphinic acid extractants and studies on their extraction–separation performance for heavy rare earths. HYDROMETALLURGY, 154 (129). [PMID:] [10.1016/j.hydromet.2015.04.001] |
15. Zhao Zheng-bai, An Shuang-shuang, Xie Hai-jiao, Jiang Yong. (2015) Copolymerization and properties of multicomponent crosslinked hydrogels. CHINESE JOURNAL OF POLYMER SCIENCE, 33 (1): (173-183). [PMID:] [10.1007/s10118-015-1565-7] |
16. Tian-Tian Yao,Jing Wang,Yun-Fan Xue,Wei-Jiang Yu,Qiang Gao,Lino Ferreira,Ke-Feng Ren,Jian Ji. (2019-08-23) A photodynamic antibacterial spray-coating based on the host-guest immobilization of the photosensitizer methylene blue.. Journal of materials chemistry. B, 7 ((33)): (5089-5095). [PMID:31432872] |