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AMG-517 - ≥99%, high purity , Vanilloid receptor antagonist, CAS No.659730-32-2, Vanilloid receptor antagonist
Basic Description Synonyms N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide | BDBM20557 | s7115 | Acetamide, N-(4-((6-(4-(trifluoromethyl)phenyl)-4-pyrimidinyl)oxy)-2-benzothiazolyl)- | CS-0980 | HMS3886D11 | DTXSID90216178 | JMC503515 Compoun Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Potent TRPV1 antagonist (IC50= 0.9 nM). Inhibits capsaican-induced flinching and reverses analgesia in an inflammatory pain model in rats. Orally bioavailable. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST, CHANNEL BLOCKER Mechanism of action Vanilloid receptor antagonist
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide INCHI InChI=1S/C20H13F3N4O2S/c1-11(28)26-19-27-18-15(3-2-4-16(18)30-19)29-17-9-14(24-10-25-17)12-5-7-13(8-6-12)20(21,22)23/h2-10H,1H3,(H,26,27,28) InChi Key YUTIXVXZQIQWGY-UHFFFAOYSA-N Canonical SMILES CC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F Isomeric SMILES CC(=O)NC1=NC2=C(C=CC=C2S1)OC3=NC=NC(=C3)C4=CC=C(C=C4)C(F)(F)F PubChem CID 16007367 Molecular Weight 430.4
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 43.04, Max Conc. mM: 100
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J2112060