Skip to the beginning of the images gallery

AMG 853 - ≥98%(HPLC), high purity , G protein-coupled receptor 44 antagonist, CAS No.1169483-24-2, G protein-coupled receptor 44 antagonist

Moligand™
≥98%(HPLC)

CAS#: 1169483-24-2
Formula: C₂₈H₂₇Cl₂FN₂O₆S
Molecular Weight: 609.49
PubChem CID: 42641863

Item Number

A286753

Grouped product items
SKU	Size	Availability	Price
A286753-5mg	5mg	In stock	$166.90
A286753-10mg	10mg	In stock	$277.90
A286753-25mg	25mg	In stock	$625.90
A286753-50mg	50mg	In stock	$789.90
A286753-100mg	100mg	In stock	$1,251.90

Potent dual CRTH2 and prostaglandin D2(PGD2) receptor antagonist

View related series

DP1 receptor Antagonist DP2 receptor Antagonist

Basic Description

Synonyms	VIDUPIPRANT\|1169483-24-2\|AMG 853\|AMG-853\|2-(4-(4-(tert-butylcarbamoyl)-2-(2-chloro-4-cyclopropylphenylsulfonamido)phenoxy)-5-chloro-2-fluorophenyl)acetic acid\|AMG 853(AMG853;Vidupiprant)\|61OTZ32XNC\|AMG853\|CHEMBL1951575\|2-[4-[4-(tert-butylcarbamoyl)-2-[(2-
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent prostaglandin D2(PGD2, CRTH2) receptor antagonist (IC50values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16-granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inh
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	G protein-coupled receptor 44 antagonist

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

Discover Target: CYP2D6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C8 Tchem Cytochrome P450 2C8 0 Activities

Discover Target: CYP2C8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2J2 Tchem Cytochrome P450 2J2 0 Activities

Discover Target: CYP2J2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A7 Tclin Cytochrome P450 3A7 0 Activities

Discover Target: CYP3A7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2B6 Tchem Cytochrome P450 2B6 0 Activities

Discover Target: CYP2B6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2E1 Tchem Cytochrome P450 2E1 0 Activities

Discover Target: CYP2E1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A5 Tclin Cytochrome P450 3A5 0 Activities

Discover Target: CYP3A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT2B7 Tchem UDP-glucuronosyltransferase 2B7 0 Activities

Discover Target: UGT2B7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT2B15 Tbio UDP-glucuronosyltransferase 2B15 0 Activities

Discover Target: UGT2B15

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A10 Tbio UDP-glucuronosyltransferase 1-10 0 Activities

Discover Target: UGT1A10

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A1 Tchem UDP-glucuronosyltransferase 1-1 0 Activities

Discover Target: UGT1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A4 Tbio UDP-glucuronosyltransferase 1-4 0 Activities

Discover Target: UGT1A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A8 Tbio UDP-glucuronosyltransferase 1-8 0 Activities

Discover Target: UGT1A8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A9 Tbio UDP-glucuronosyltransferase 1-9 0 Activities

Discover Target: UGT1A9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR Tclin Prostaglandin D2 receptor 3 Activities

Discover Target: PTGDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGDR2 Tchem Prostaglandin D2 receptor 2 3 Activities

Discover Target: PTGDR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CAPN1 Tchem Calpain-1 catalytic subunit 0 Activities

Discover Target: CAPN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A3 Tbio UDP-glucuronosyltransferase 1-3 0 Activities

Discover Target: UGT1A3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A6 Tbio UDP-glucuronosyltransferase 1-6 0 Activities

Discover Target: UGT1A6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A7 Tbio UDP-glucuronosyltransferase 1-7 0 Activities

Discover Target: UGT1A7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT2B4 Tbio UDP-glucuronosyltransferase 2B4 0 Activities

Discover Target: UGT2B4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT2B17 Tbio UDP-glucuronosyltransferase 2B17 0 Activities

Discover Target: UGT2B17

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	2-[4-[4-(tert-butylcarbamoyl)-2-[(2-chloro-4-cyclopropylphenyl)sulfonylamino]phenoxy]-5-chloro-2-fluorophenyl]acetic acid
INCHI	InChI=1S/C28H27Cl2FN2O6S/c1-28(2,3)32-27(36)17-6-8-23(39-24-14-21(31)18(11-19(24)29)13-26(34)35)22(12-17)33-40(37,38)25-9-7-16(10-20(25)30)15-4-5-15/h6-12,14-15,33H,4-5,13H2,1-3H3,(H,32,36)(H,34,35)
InChi Key	PFWVGKROPKKEDW-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C)NC(=O)C1=CC(=C(C=C1)OC2=C(C=C(C(=C2)F)CC(=O)O)Cl)NS(=O)(=O)C3=C(C=C(C=C3)C4CC4)Cl
Isomeric SMILES	CC(C)(C)NC(=O)C1=CC(=C(C=C1)OC2=C(C=C(C(=C2)F)CC(=O)O)Cl)NS(=O)(=O)C3=C(C=C(C=C3)C4CC4)Cl
PubChem CID	42641863
Molecular Weight	609.49

PubChem CID

BindingDB Ligand

ChEMBL Ligand

CAS Registry No.

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

5 results found

Lot Number	Certificate Type	Date	Item
K2217140	Certificate of Analysis	Aug 22, 2022	A286753
K2217141	Certificate of Analysis	Aug 22, 2022	A286753
K2217142	Certificate of Analysis	Aug 22, 2022	A286753
K2217150	Certificate of Analysis	Aug 22, 2022	A286753
K2217151	Certificate of Analysis	Aug 22, 2022	A286753

References

1. Busse WW, Wenzel SE, Meltzer EO, Kerwin EM, Liu MC, Zhang N, Chon Y, Budelsky AL, Lin J, Lin SL. (2013) Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.. J Allergy Clin Immunol, 131 (2): (339-45). [PMID:23174659]
2. Liu J, Li AR, Wang Y, Johnson MG, Su Y, Shen W, Wang X, Lively S, Brown M, Lai S et al.. (2011) Discovery of AMG 853, a CRTH2 and DP Dual Antagonist.. ACS Med Chem Lett, 2 (5): (326-30). [PMID:24900313]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.