Grouped product items

SKU

Size

Availability

Price

Qty

A129924-1mg

1mg

In stock

$33.90

A129924-5mg

5mg

In stock

$140.90

A129924-10mg

10mg

In stock

$245.90

A129924-25mg

25mg

In stock

$553.90

A129924-50mg

50mg

In stock

$768.90

A129924-100mg

100mg

Available within 8-12 weeks(?)

$1,303.90

A129924-250mg

250mg

Available within 4-8 weeks(?)

$2,934.90

Basic Description

Synonyms	AMG-900\|945595-80-2\|AMG 900\|AMG900\|N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine\|N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine\|N-[4-[3-(2-aminopyri
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	AMG 900 is a novel potent and highly selective Pan-aurora kinase inhibitor with an IC50 of median 3.5 nM. AMG 900 repressed autophosphorylation of aurorakinases A and B as well as the phosphorylation of histone H3.The predominant cellular
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Serine/threonine-protein kinase Aurora inhibitor

Product Properties

ALogP	5.1

Associated Targets

CDK1 Tchem Cyclin-dependent kinase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EPHB6 Tchem Ephrin type-B receptor 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DNAJA1 Tchem DnaJ homolog subfamily A member 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK9 Tchem Cyclin-dependent kinase 9 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK16 Tchem Cyclin-dependent kinase 16 0 Activities

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BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK17 Tchem Cyclin-dependent kinase 17 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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CDK5 Tchem Cyclin-dependent-like kinase 5 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IARS2 Tchem Isoleucine--tRNA ligase, mitochondrial 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

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TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

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IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKACG Tchem cAMP-dependent protein kinase catalytic subunit gamma 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SIK2 Tchem Serine/threonine-protein kinase SIK2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM2 Tchem Serine/threonine-protein kinase pim-2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MCM4 Tchem DNA replication licensing factor MCM4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B 3 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKC Tchem Aurora kinase C 2 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK2 Tclin Activated CDC42 kinase 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACAD10 Tchem Acyl-CoA dehydrogenase family member 10 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

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AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

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AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHEK1 Tchem Serine/threonine-protein kinase Chk1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3A Tclin Glycogen synthase kinase-3 alpha 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 0 Activities

Discover Target: MAP2K1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-[3-(2-aminopyrimidin-4-yl)pyridin-2-yl]oxyphenyl]-4-(4-methylthiophen-2-yl)phthalazin-1-amine
INCHI	InChI=1S/C28H21N7OS/c1-17-15-24(37-16-17)25-20-5-2-3-6-21(20)26(35-34-25)32-18-8-10-19(11-9-18)36-27-22(7-4-13-30-27)23-12-14-31-28(29)33-23/h2-16H,1H3,(H,32,35)(H2,29,31,33)
InChi Key	IVUGFMLRJOCGAS-UHFFFAOYSA-N
Canonical SMILES	CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N
Isomeric SMILES	CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N
PubChem CID	24856041
Molecular Weight	503.58

Database links

PubChem CID	24856041
CAS Registry No.	945595-80-2
ChEMBL Ligand	CHEMBL2140408

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
A2214256	Certificate of Analysis	Oct 16, 2023	A129924
A2214257	Certificate of Analysis	Oct 16, 2023	A129924
A2214261	Certificate of Analysis	Oct 16, 2023	A129924
A2214263	Certificate of Analysis	Oct 16, 2023	A129924
A2214270	Certificate of Analysis	Oct 16, 2023	A129924
A2214271	Certificate of Analysis	Oct 16, 2023	A129924
A2214259	Certificate of Analysis	Dec 24, 2021	A129924

Chemical and Physical Properties

Solubility	≥25.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection.

References

1. Payton M, Bush TL, Chung G, Ziegler B, Eden P, McElroy P, Ross S, Cee VJ, Deak HL, Hodous BL et al.. (2010) Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.. Cancer Res, 70 (23): (9846-54). [PMID:20935223]
2. Willemsen-Seegers N, Uitdehaag JCM, Prinsen MBW, de Vetter JRF, de Man J, Sawa M, Kawase Y, Buijsman RC, Zaman GJR. (2017) Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.. J Mol Biol, 429 (4): (574-586). [PMID:28043854]

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AMG-900 - 98%, high purity , Serine/threonine-protein kinase Aurora inhibitor, CAS No.945595-80-2, Serine/threonine-protein kinase Aurora inhibitor

Basic Description

Product Properties

Associated Targets

CDK1 Tchem Cyclin-dependent kinase 1 0 Activities

EPHB6 Tchem Ephrin type-B receptor 6 0 Activities

EGFR Tclin Epidermal growth factor receptor 0 Activities

DNAJA1 Tchem DnaJ homolog subfamily A member 1 0 Activities

CDK9 Tchem Cyclin-dependent kinase 9 0 Activities

CDK16 Tchem Cyclin-dependent kinase 16 0 Activities

BRD4 Tchem Bromodomain-containing protein 4 0 Activities

CDK17 Tchem Cyclin-dependent kinase 17 0 Activities

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

CDK5 Tchem Cyclin-dependent-like kinase 5 0 Activities

SRC Tclin Proto-oncogene tyrosine-protein kinase Src 0 Activities

IARS2 Tchem Isoleucine--tRNA ligase, mitochondrial 0 Activities

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

HDAC6 Tclin Histone deacetylase 6 0 Activities

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

MET Tclin Hepatocyte growth factor receptor 0 Activities

IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

PRKACG Tchem cAMP-dependent protein kinase catalytic subunit gamma 0 Activities

SIK2 Tchem Serine/threonine-protein kinase SIK2 0 Activities

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

PIM2 Tchem Serine/threonine-protein kinase pim-2 0 Activities

MCM4 Tchem DNA replication licensing factor MCM4 0 Activities

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 0 Activities

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

AURKA Tchem Aurora kinase A 3 Activities

AURKB Tchem Aurora kinase B 3 Activities

AURKC Tchem Aurora kinase C 2 Activities

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

TNK2 Tclin Activated CDC42 kinase 1 0 Activities

ACAD10 Tchem Acyl-CoA dehydrogenase family member 10 0 Activities

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

CHEK1 Tchem Serine/threonine-protein kinase Chk1 0 Activities

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

GSK3A Tclin Glycogen synthase kinase-3 alpha 0 Activities

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

JAK2 Tclin Tyrosine-protein kinase JAK2 0 Activities

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 0 Activities

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

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