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AMG28 , CAS No.A607602, Inhibitor of mitogen-activated protein kinase kinase kinase 14;Inhibitor of p21 (RAC1) activated kinase 4;Inhibitor of p21 (RAC1) activated kinase 5;Inhibitor of p21 (RAC1) activated kinase 6;Inhibitor of phosphoinositide kinase; FYVE-type zinc finger con

PubChem CID: 58221549

Item Number

A607602

Grouped product items
SKU	Size	Availability	Price	Qty
A607602-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607602-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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mitogen-activated protein kinase kinase kinase 14 Inhibitor p21 (RAC1) activated kinase 4 Inhibitor p21 (RAC1) activated kinase 5 Inhibitor p21 (RAC1) activated kinase 6 Inhibitor phosphoinositide kinase，FYVE-type zinc finger containing Inhibitor TAO kinase 1 Inhibitor TAO kinase 2 Inhibitor TAO kinase 3 Inhibitor tau tubulin kinase 1 Inhibitor

Basic Description

Synonyms	example 240;inhibitor 3
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase kinase kinase 14;Inhibitor of p21 (RAC1) activated kinase 4;Inhibitor of p21 (RAC1) activated kinase 5;Inhibitor of p21 (RAC1) activated kinase 6;Inhibitor of phosphoinositide kinase; FYVE-type zinc finger con

Associated Targets(Human)

PAK5 Tchem Serine/threonine-protein kinase PAK 5 (0 Activities)

Discover Target: PAK5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIKFYVE Tchem 1-phosphatidylinositol 3-phosphate 5-kinase (0 Activities)

Discover Target: PIKFYVE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TTBK1 Tbio Tau-tubulin kinase 1 (0 Activities)

Discover Target: TTBK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAOK1 Tchem Serine/threonine-protein kinase TAO1 (0 Activities)

Discover Target: TAOK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAOK2 Tchem Serine/threonine-protein kinase TAO2 (0 Activities)

Discover Target: TAOK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TAOK3 Tchem Serine/threonine-protein kinase TAO3 (0 Activities)

Discover Target: TAOK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP3K14 Tchem Mitogen-activated protein kinase kinase kinase 14 (0 Activities)

Discover Target: MAP3K14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PAK4 Tchem Serine/threonine-protein kinase PAK 4 (0 Activities)

Discover Target: PAK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PAK6 Tchem Serine/threonine-protein kinase PAK 6 (0 Activities)

Discover Target: PAK6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

JAK2 Tclin Tyrosine-protein kinase JAK2 (12915 Activities)

Discover Target: JAK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP2K4 Tchem Dual specificity mitogen-activated protein kinase kinase 4 (1051 Activities)

Discover Target: MAP2K4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PAK6 Tchem Serine/threonine-protein kinase PAK6 (1915 Activities)

Discover Target: PAK6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PAK5 Tchem Serine/threonine-protein kinase PAK7 (1760 Activities)

Discover Target: PAK5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP4K5 Tchem Mitogen-activated protein kinase kinase kinase kinase 5 (1523 Activities)

Discover Target: MAP4K5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PAK4 Tchem Serine/threonine-protein kinase PAK 4 (3212 Activities)

Discover Target: PAK4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP4K2 Tchem Mitogen-activated protein kinase kinase kinase kinase 2 (2692 Activities)

Discover Target: MAP4K2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAOK1 Tchem Serine/threonine-protein kinase TAO1 (2019 Activities)

Discover Target: TAOK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MYLK4 Tchem Myosin light chain kinase family member 4 (320 Activities)

Discover Target: MYLK4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CIT Tchem Citron Rho-interacting kinase (570 Activities)

Discover Target: CIT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRKX Tchem Serine/threonine-protein kinase PRKX (2278 Activities)

Discover Target: PRKX

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP3K14 Tchem Mitogen-activated protein kinase kinase kinase 14 (1412 Activities)

Discover Target: MAP3K14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP3K3 Tchem Mitogen-activated protein kinase kinase kinase 3 (562 Activities)

Discover Target: MAP3K3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSSK1B Tchem Testis-specific serine/threonine-protein kinase 1 (2038 Activities)

Discover Target: TSSK1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAOK3 Tchem Serine/threonine-protein kinase TAO3 (1005 Activities)

Discover Target: TAOK3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP3K2 Tchem Mitogen-activated protein kinase kinase kinase 2 (593 Activities)

Discover Target: MAP3K2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP3K19 Tchem SPS1/STE20-related protein kinase YSK4 (285 Activities)

Discover Target: MAP3K19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TAOK2 Tchem Serine/threonine-protein kinase TAO2 (964 Activities)

Discover Target: TAOK2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIP4K2C Tchem Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma (641 Activities)

Discover Target: PIP4K2C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIP5K1C Tchem Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (331 Activities)

Discover Target: PIP5K1C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DSTYK Tchem Dual serine/threonine and tyrosine protein kinase (235 Activities)

Discover Target: DSTYK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TTBK1 Tbio Tau-tubulin kinase 1 (179 Activities)

Discover Target: TTBK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PIKFYVE Tchem 1-phosphatidylinositol 3-phosphate 5-kinase (270 Activities)

Discover Target: PIKFYVE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

INCHI	InChI=1S/C20H20N4O/c1-20(2,25)9-8-12-6-7-15-14(10-12)17-16(23-15)5-3-4-13-11-22-19(21)24-18(13)17/h6-7,10-11,23,25H,3-5H2,1-2H3,(H2,21,22,24)
InChi Key	DGLFSNZWRYADFC-UHFFFAOYSA-N
Canonical SMILES	CC(C)(C#Cc1cc2c(cc1)[nH]c1c2c2c(CCC1)cnc(n2)N)O
Isomeric SMILES	CC(C)(C#CC1=CC2=C(C=C1)NC3=C2C4=NC(=NC=C4CCC3)N)O
PubChem CID	58221549

PubChem CID

ChEMBL Ligand

BindingDB Ligand

RCSB PDB Ligand

References

1. Halkina T, Henderson JL, Lin EY, Himmelbauer MK, Jones JH, Nevalainen M, Feng J, King K, Rooney M, Johnson JL et al.. (2021) Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo.. J Med Chem, 64 (9): (6358-6380). [PMID:33944571] [10.1021/op500134e]

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AMG28 , CAS No.A607602, Inhibitor of mitogen-activated protein kinase kinase kinase 14;Inhibitor of p21 (RAC1) activated kinase 4;Inhibitor of p21 (RAC1) activated kinase 5;Inhibitor of p21 (RAC1) activated kinase 6;Inhibitor of phosphoinositide kinase; FYVE-type zinc finger con

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator